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CompletedNCT00583245Updated Mar 10, 2017

Improving Walking in Older Adults With Knee Osteoarthritis

An interventional study of Gait Training in Knee Osteoarthritis, sponsored by University of Iowa. Completed at 1 site in United States. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2017-03-10.

Sponsored by University of Iowa · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
27
Allocation
Not applicable
Ages
60 Years and older
Sex
All
01

Study summary

Knee osteoarthritis (OA) accounts for a significant proportion of mobility limitations and is one of the most disabling problems facing the growing population of older adults. The long-term objective of this research is to reduce disablement of older adults with symptomatic knee OA. The principle of specificity of training indicates that exercises that closely approximate the goal functional activity are most effective in improving physical performance during that activity. Based on this principle, the specific aim of this pilot study is to design a patient-specific gait training intervention using analysis of compensatory joint moments and energy expenditure. Successful completion will inform rehabilitation for maintaining or improving mobility as well as explore the mechanism of effect.

02

Conditions studied

  • Knee Osteoarthritis

Keywords

  • Osteoarthritis
  • Gait training
  • Knee pain
  • Rehabilitation
  • Physical Therapy
03

In context

Osteoarthritis

4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.

This study's enrollment of 27 is below the median of 70 across 3,440 interventional studies indexed under Osteoarthritis.

Browse Osteoarthritis studies →

Lead sponsor

University of Iowa is the lead sponsor of 276 studies on the registry; 35 are open to participants now.

Of its 44 completed or terminated interventional studies of FDA-regulated products, 39 (89%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
60 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Symptomatic knee osteoarthritis (knee osteoarthritis diagnosed by x-ray and frequent knee symptoms)
  • Age 60 or older

Exclusion criteria

Exclusion Criteria:

  • acute or terminal illness
  • unstable cardiovascular condition or other medical conditions that may impair ability to participate such as pulmonary disease requiring the use of supplemental oxygen, neurological disease that affects gait, or lower limb musculoskeletal surgery in the past 6 months.
  • Bilateral knee replacement
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
27 participants (actual)

Study arms

  • Experimental
    1

    Gait training

    Other: Gait Training

Interventions

  • OtherGait Training

    Gait training with physical therapist 2/week for 3 months

06

What researchers measure

Primary outcomes

  1. Changes in functional limitation assessed by the A) Summary Performance Score which includes balance tests, timed 4-meter walk, and timed chair stand test B) Timed stair climb C) Late Life Function and Disability Instrument (LLFDI) Questionnaire

    Time frame: 12 weeks

  2. Changes in the disability measure, a timed 400 meter walk

    Time frame: 12 Weeks

  3. Changes in impairments assessed using the Knee and Osteoarthritis Outcome Score (KOOS) questionnaire

    Time frame: 12 Weeks

07

Study locations

1 site
  • University of Iowa
    Iowa City, Iowa 52242, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 10, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00583245
Lead sponsor
University of Iowa
Collaborators
National Institute on Aging (NIA)
Responsible party
Neil A Segal (Professor, University of Iowa) — Principal investigator
First posted
Dec 31, 2007
Start date
Dec 2007
Primary completion
Sep 2008
Completion
Dec 2009
Last update
Mar 10, 2017

Study contacts

Neil Segal, MD
principal investigator · University of Iowa

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2017. You cannot join it, but the record below documents what was studied.

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