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CompletedNCT00572390Updated Dec 13, 2007

Oestrogen Withdrawal in Hypopituitary Women

An interventional study of oestrogen in Hypopituitarism, sponsored by University of Aarhus. Completed at 1 site in Denmark. Open to female participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2007-12-13.

Sponsored by University of Aarhus · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
38
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
Female
01

Study summary

By exploring hormonal status in hypopituitary women during oestrogen treatment and without estrogen substitution the influence on sexhormones and organ function is estimated.

Read the detailed description

38 hypopituitary women were examinined twice. During oestrogen treatment and after 1 month estrogen withdrawal. A control group of healthy women were examined once.Antropometric data and hormonal parameters were collected.

02

Conditions studied

  • Hypopituitarism

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03

In context

Hypopituitarism

47 studies on the registry are indexed under Hypopituitarism; 8 are open to participants now.

This study's enrollment of 38 is close to the median of 38 across 29 interventional studies indexed under Hypopituitarism.

Browse Hypopituitarism studies →

Lead sponsor

University of Aarhus is the lead sponsor of 1,300 studies on the registry; 189 are open to participants now.

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Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes

Eligibility criteria

Inclusion Criteria:

  • Hypopituitarism
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
38 participants (actual)

Study arms

  • Placebo comparator
    1

    No oestrogen treatment

    Drug: oestrogen

  • Experimental
    2

    Oestrogen treatment

    Drug: oestrogen

Interventions

  • Drugoestrogen

    Cyclic oestrogen substitution therapy

06

What researchers measure

Primary outcomes

  1. androgens, IGF-I, body composition, liver enzymes,

    Time frame: 1 month

Secondary outcomes

  1. Grehlin, adiponection, leptin

    Time frame: 1 month

07

Study locations

1 site
  • Århus Universityhospital
    Århus, dk-8000, Denmark
08

References and documents

Publications

  • Host C, Christiansen JJ, Christiansen JS, Jorgensen JO, Gravholt CH. Discontinuation of hormone replacement therapy in young GH-treated hypopituitary women increases liver enzymes. Growth Horm IGF Res. 2010 Feb;20(1):26-30. doi: 10.1016/j.ghir.2009.07.001. Epub 2009 Aug 5. PubMed 19660970 ↗
09

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Jan 2001 and a completion of Feb 2002. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Dec 11, 2007
First posted
Dec 13, 2007
Start
Jan 2001
CompletionActual
Feb 2002
Last update
Dec 13, 2007
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Dec 13, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00572390
Lead sponsor
University of Aarhus
First posted
Dec 13, 2007
Start date
Jan 2001
Completion
Feb 2002
Last update
Dec 13, 2007

Study contacts

Jens J Christiansen, PhD
principal investigator · Århus Universityhospital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2007. You cannot join it, but the record below documents what was studied.

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