An observational study in Osteoarthritis, Knee, sponsored by University of California, San Francisco. Completed at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-12-12.
Sponsored by University of California, San Francisco · Observational
The purpose of this study is to use better magnetic resonance imaging (MRI) techniques to examine the knee and the bony and soft tissue changes so as to better predict the progression of osteoarthritis and acute knee injuries.
The study will examine the pathophysiology of bone marrow changes, relationship between trabecular bone and cartilage changes; and evaluate T1p relaxation methods and its' relating to cartilage loss. The protocol is geared towards sequences utilizing 3 Tesla magnetic resonance imaging (MRI) that will enable the measures of cartilage volume and T2. Measures cartilage volume and T2 are more established MR methods for studying osteoarthritis (OA).
All OA and Anterior cruciate ligament (ACL) subjects will undergo MR imaging of the knee joint at 3 Tesla at baseline,, and three annual follow up time points. Regions of interest will include the total tibial and femoral cartilage, and sub-division such as the medial and lateral compartments of the tibial and femoral cartilage to account for localized disease activity and progression.
Bone marrow edema size, MR spectroscopy based marrow fat/water content, and trabecular bone microarchitecture underlying the edema will be measured in the OA and ACL groups to determine whether there is any distinction between these measures in OA and in traumatic ACL injury, cross-sectionally and longitudinally, and their relation to cartilage loss and OA progression.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
This study's enrollment of 139 is above the median of 100 across 791 observational studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →University of California, San Francisco is the lead sponsor of 2,132 studies on the registry; 375 are open to participants now.
Of its 262 completed or terminated interventional studies of FDA-regulated products, 196 (75%) have results posted.
Counted across the registry records on this site, refreshed daily.
Recruitment flyers are posted at different UCSF campuses and those staff and students. Patient eligibility will determined initially bye the referring orthopedist.
Exclusion Criteria:
Healthy volunteers without knee pain.
Patients with mild arthritic symptoms and radiographic changes (Kellgren Lawrence score of 1, 2)
Patients with severe pain and functional limitations associated with knee arthritis (Kellgren Lawrence score of 3, 4).
Procedure: Total Knee Replacement
Patients with acute anterior cruciate ligament (ACL) injuries with associated osseous contusion.
Procedure: ACL Reconstruction Surgery
Patients with posttraumatic knee injury or degenerative condition and will have cartilage resurfacing procedures.
Procedure: Cartilage Resurfacing Surgery
Pathophysiology of bone marrow changes, relationship between trabecular bone and cartilage changes
Time frame: Baseline, 1 year, 2 year, 3 year
Evaluate T1rho relaxation methods and its' relation to cartilage loss
Time frame: Baseline, 1 year, 2 year, 3 year
This study is completed, as verified in Dec 2013. You cannot join it, but the record below documents what was studied.
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University of California, San Francisco