An observational study in Chronic Obstructive Pulmonary Disease and Acute Respiratory Failure, sponsored by University Hospital, Grenoble. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-06-06.
Sponsored by University Hospital, Grenoble · Observational
The main objective of the study is to evaluate the predictive factors of the endothelial function to the waning of an acute exacerbation in COPD. It will act to do a multivariate analysis to determine the respective weight of the parameters of the systemic inflammation, of the oxidative stress of the functional respiratory parameters and then functional respiratory parameters.
In exacerbated Chronic Obstructive Pulmonary Disease (COPD) patients, there is augmentation of hypoxia and the obstructive ventilatory disorders is more important. This is correlated with an increase in C-reactive Protein (CRP) and of inflammatory cytokines and oxidative stress. It has been demonstrated that there is an endothelial dysfunction in answer to hypoxia. Since the exacerbated COPD patients are hypoxic in most cases , we suppose they have an endothelial dysfunction during exacerbation. So we think we will find an augmentation of vascular resistances ,shown by a peripheral arterial tone too high. And this, certainly, play a part in physiopathology of the COPD exacerbation.
We want to judge the improvement of the endothelial function remotely to the acute exacerbation (6 weeks). And then we would like to correlate this improvement with the variations of oxidative stress, muscle strength, respiratory function and systemic inflammation.
We also would like to find a relation between the new hospitalizations for respiratory exacerbation and the initial value of endothelial function.
Then we would like to evaluate the relationship between the cardiovascular risk and the COPD severity.
3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.
This study's enrollment of 121 is below the median of 157 across 929 observational studies indexed under Lung Diseases.
Browse Lung Diseases studies →University Hospital, Grenoble is the lead sponsor of 815 studies on the registry; 205 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with exacerbated (50) or stable (195) COPD
Exclusion Criteria:
Patients with exacerbated COPD
Patients with stable COPD
peripheral arterial tone
Time frame: once a year
Muscle strength measurements
Time frame: once a year
biological markers of inflammation and oxidative stress
Time frame: once a year
respiratory function measurements
Time frame: once a year
Determine the relationship between the RMI measurements and the cardiovascular risk
Time frame: once during the study
Determine the relationship between the hospitalizations for decompensation and the initial value of endothelial function
Time frame: study time frame
Determine the relationship between the RMI measurements and the COPD severity
Time frame: once during the study
Determine the prevalence of nocturnal non-dipping blood pressure in COPD patients
Time frame: once a year
pulse wave velocity measurement
Time frame: once a year
This study is completed, as verified in Jun 2022. You cannot join it, but the record below documents what was studied.
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University Hospital, Grenoble