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CompletedNCT00358306Updated May 14, 2020

The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

An observational study in Acute Renal Failure, Chronic Kidney Failure and Endothelial Dysfunction, sponsored by University of Alabama at Birmingham. Completed at 1 site in United States. Open to participants aged 2 Years to 20 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-05-14.

Sponsored by University of Alabama at Birmingham · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
36
Ages
2 Years to 20 Years
Sex
All
01

Study summary

To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.

Read the detailed description

This research study is designed to study what happens to the kidneys after they have an injury. There is some evidence that even if there appears to be great improvement of kidney function, an injury can put patients at risk for long-term problems with their kidney function and increase their risk to have high blood pressure. We want to collect information from participants to help explain why this injury can cause future problems, including Chronic Kidney Disease (CKD) which may help us prevent these health problems.

02

Conditions studied

  • Acute Renal Failure
  • Chronic Kidney Failure
  • Endothelial Dysfunction
  • Hemolytic-uremic Syndrome (HUS)

Keywords

  • Endothelium
  • Chronic Kidney Disease
  • Acute Kidney Injury
  • Hemolytic-uremic syndrome (HUS)
03

In context

Kidney Diseases

3,840 studies on the registry are indexed under Kidney Diseases; 500 are open to participants now.

This study's enrollment of 36 is below the median of 192 across 1,033 observational studies indexed under Kidney Diseases.

Browse Kidney Diseases studies →

Lead sponsor

University of Alabama at Birmingham is the lead sponsor of 1,396 studies on the registry; 284 are open to participants now.

Of its 156 completed or terminated interventional studies of FDA-regulated products, 124 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
2 Years to 20 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Children 2-20 years old with history of acute kidney injury

Inclusion criteria

  • Children between age 2-20
  • Decrease in renal function by 25% or greater
  • Renal function has returned to normal

Exclusion criteria

Exclusion Criteria:

  • History of chronic disease
  • Cancer
  • Congenital heart disease
  • Organ Transplantation
  • Liver disease
  • Pulmonary disease
  • Diabetes other primary metabolic condition
  • Severe neurologic impairments
  • Hypertension
  • Auto-immune
  • Infectious disease or renal disease
  • Smokers
  • Renal disease w/primary cause i.e. - HUS or Glomerulonephritis
  • severe allergies including allergy to seafood and/or iodine
05

Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
36 participants (actual)

Groups and cohorts

  • a

    those with previous history of Acute kidney injury

06

Study locations

1 site
  • University Of Alabama
    Birmingham, Alabama 35233, United States
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 14, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00358306
Lead sponsor
University of Alabama at Birmingham
Responsible party
David Askenazi (Principal Investigator, University of Alabama at Birmingham) — Principal investigator
First posted
Jul 31, 2006
Start date
Apr 2008
Primary completion
Jul 2009
Completion
Jul 2009
Last update
May 14, 2020

Study contacts

David Askenazi, MD
principal investigator · UAB Pediatric Nephrology

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2020. You cannot join it, but the record below documents what was studied.

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