A Phase 4 interventional study of Misoprostol and PGE2 gel in Premature Rupture of Membranes at Term, sponsored by Nilratan Sircar Medical College. Completed at 1 site in India. Open to female participants. Per ClinicalTrials.gov, last updated 2010-03-25.
Sponsored by Nilratan Sircar Medical College · Phase 4, Interventional, and Treatment
Induction of labour with vaginal misoprostol, in women with premature rupture of membranes at term, results in significant shortening of induction to delivery time in comparison to vaginal PGE2 gel induction.
100 studies on the registry are indexed under Fetal Membranes, Premature Rupture; 23 are open to participants now.
This study's enrollment of 212 is above the median of 150 across 59 interventional studies indexed under Fetal Membranes, Premature Rupture.
Browse Fetal Membranes, Premature Rupture studies →Nilratan Sircar Medical College is the lead sponsor of 8 studies on the registry; none are open to participants now.
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In group A, immediate induction of labour will be done by intravaginal misoprostol 25 microgram 4 hourly , a maximum of 5 doses .
Drug: Misoprostol
In Group B immediate induction of labour will be done by application of vaginal PGE2 gel 0.5 gm at an interval of 6 hours , a maximum of 2 doses.
Drug: PGE2 gel
In one group of women immediate induction of labour will be done by intravaginal misoprostol 25 microgram 4 hourly , a maximum of 5 doses .
In other group immediate induction of labour will be done by intravaginal application of PGE2 gel 0.5 mg at an interval of 6 hours , a maximum of 2 doses.
Admission to delivery time
Time frame: 48 hours
Caesarean Section rate
Time frame: 48 hours
Neonatal morbidity
Time frame: Till discharge
Maternal morbidity
Time frame: Till discharge
The record gives a start of Aug 2006, a primary completion of Sep 2008 and a completion of Sep 2008. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Nov 2008. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Misoprostol · Dinoprostone
Fetal Membranes, Premature Rupture →
Nilratan Sircar Medical College