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CompletedNCT00300794Updated Nov 14, 2006

Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia

A Phase 4 interventional study of Ketamine in Opiate Dependence, sponsored by Vilnius University. Completed at 1 site in Lithuania. Open to participants aged 18 Years to 35 Years. Per ClinicalTrials.gov, last updated 2006-11-14.

Sponsored by Vilnius University · Phase 4, Interventional, and Treatment

Phase
Phase 4
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
All
01

Study summary

The purpose of this study is to determine whether low-dose ketamine infusion is effective in suppressing the symptoms of opiate withdrawal during rapid opiate antagonist induction (RAI).

02

Conditions studied

  • Opiate Dependence
03

In context

Opioid-Related Disorders

1,411 studies on the registry are indexed under Opioid-Related Disorders; 290 are open to participants now.

This study's enrollment of 60 is close to the median of 63 across 1,123 interventional studies indexed under Opioid-Related Disorders.

Browse Opioid-Related Disorders studies →

Lead sponsor

Vilnius University is the lead sponsor of 60 studies on the registry; 12 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Diagnosed opiate dependence according to ICD 10 and/or DSM 4;
  • Duration of substance abuse more than 1 year
  • No or minor co-morbidities;
  • Grade I-II according to physical status classification system of American Society of Anesthesiologists.

Exclusion criteria

Exclusion Criteria:

  • Current history of long acting opiate or poly-substance abuse;
  • Acute medical or surgical condition;
  • Pregnancy;
  • Breastfeeding.
05

Study design

Phase
Phase 4
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double
Enrollment
60 participants

Interventions

  • DrugKetamine
06

Study locations

1 site
  • Vilnius University Emergency Hospital
    Vilnius, Lithuania
07

References and documents

Publications

  • Ivaskevicius J, Jovaisa T, Laurinenas G, Vosylius S, Sipylaite J, Badaras R. [Safety and effectiveness of opiate antagonist detoxification under general anesthesia]. Medicina (Kaunas). 2005;41(12):1011-8. Lithuanian. PubMed 16401957 ↗
  • Jovaisa T, Laurinenas G, Vosylius S, Sipylaite J, Badaras R, Ivaskevicius J. Effects of ketamine on precipitated opiate withdrawal. Medicina (Kaunas). 2006;42(8):625-34. PubMed 16963828 ↗
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 14, 2006, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00300794
Lead sponsor
Vilnius University
First posted
Mar 9, 2006
Start date
Feb 2003
Completion
Jun 2006
Last update
Nov 14, 2006

Study contacts

Juozas Ivaskevicius, Prof.
study director · Vilnius University Clinic of Anaesthesiology and Intensive Care
Tomas Jovaisa, MD
principal investigator · Vilnius University Clinic of Anaesthesiology and Intensive Care
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2006. You cannot join it, but the record below documents what was studied.

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