CompletedNCT00141440Updated Dec 30, 2009

The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients

An interventional study of mechanical ventilation in Chronic Obstructive Pulmonary Disease, sponsored by Policlinico Hospital. Completed at 1 site in Italy. Open to participants aged 16 Years to 90 Years. Per ClinicalTrials.gov, last updated 2009-12-30.

Sponsored by Policlinico Hospital · Not applicable, Interventional, and Treatment

Phase: Not applicable
Study type: Interventional
Enrollment: 13
Allocation: Randomized
Ages: 16 Years to 90 Years
Sex: All

Study summary

The investigators' aim is to study the effect of cycling off criteria during pressure support ventilation in COPD patients at two levels of PEEP and PSV.

Read the detailed description

In this study two levels of cycling off criteria at two levels of PEEP and PSV were tested in term of gas exchange, respiratory mechanics, work of breathing and patient comfort.

Conditions studied

Chronic Obstructive Pulmonary Disease

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Keywords

gas exchange
pressure support ventilation
respiratory mechanics
COPD patients

In context

Lung Diseases

3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.

This study's enrollment of 13 is below the median of 72 across 2,118 interventional studies indexed under Lung Diseases.

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Lead sponsor

Policlinico Hospital is the lead sponsor of 65 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 16 Years to 90 Years
Sexes eligible: All
Accepts healthy volunteers: No

Inclusion criteria

Stable COPD patients during invasive mechanical ventilation

Exclusion criteria

Exclusion Criteria:

Hemodynamic instability,
Paralysis

Study design

Phase: Not applicable
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Single group
Masking: None (open label)
Enrollment: 13 participants (actual)

Study arms

Experimental
1
COPD patients
Procedure: mechanical ventilation

Interventions

Proceduremechanical ventilation
evaluated the effect of two different cycling off criteria on breathing pattern, respiratory effort, and gas exchange in patients with chronic obstructive pulmonary disease

What researchers measure

Primary outcomes

Respiratory mechanics, gas exchange
Time frame: 2 minutes

Secondary outcomes

Comfort of breathing
Time frame: 2 minutes

Study locations

1 site

Ospedale Sacco
Milano, 20100, Italy

References and documents

Publications

Chiumello D, Polli F, Tallarini F, Chierichetti M, Motta G, Azzari S, Colombo R, Rech R, Pelosi P, Raimondi F, Gattinoni L. Effect of different cycling-off criteria and positive end-expiratory pressure during pressure support ventilation in patients with chronic obstructive pulmonary disease. Crit Care Med. 2007 Nov;35(11):2547-52. doi: 10.1097/01.CCM.0000287594.80110.34. PubMed 17893630 ↗

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Dec 30, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT00141440
Lead sponsor: Policlinico Hospital
First posted: Sep 1, 2005
Start date: Jul 2005
Primary completion: Mar 2007
Completion: Mar 2007
Last update: Dec 30, 2009

Study contacts

davide chiumello, md

principal investigator · Policlinico Hospital

Davide Chiumello, MD

study chair · Policlinico

Oversight

Data monitoring committee: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2008. You cannot join it, but the record below documents what was studied.

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Discussion

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