A Phase 1 interventional study of Fludrocortisone and Domperidone in Parkinson's Disease, Multiple System Atrophy and Orthostatic Hypotension, sponsored by Royal Brisbane and Women's Hospital. Completed at 1 site in Australia. Open to participants aged 40 Years to 95 Years. Per ClinicalTrials.gov, last updated 2005-10-20.
Sponsored by Royal Brisbane and Women's Hospital · Phase 1, Interventional, and Treatment
Patients with Parkinson's Disease or Multiple System Atrophy (MSA), and symptoms of orthostatic hypotension, are eligible for the study. Each patient will have three weeks of conservative therapy, three weeks of therapy with fludrocortisone, and three weeks of therapy with domperidone. Autonomic testing, a symptom questionnaire, bedside blood pressure testing, and Unified Parkinson Disease Rating Scale (UPDRS) will be performed after each intervention.
Enrolled patients, ages 40-95, must have Parkinson's or MSA, diagnosed by a neurologist, and symptoms of orthostatic hypotension. Each patient will fill out two validated questionnaires to determine if they are candidates for the study. Baseline patient details, such as their medications and UPDRS, will be recorded. Medications must be held stable during the period of the study.
Each patient will then have three weeks of conservative therapy, three weeks of therapy with fludrocortisone, and three weeks of therapy with domperidone. Autonomic testing, a symptom questionnaire, bedside blood pressure testing, and UPDRS will be performed after each intervention.
Exclusion Criteria:
Efficacy of conservative treatment, domperidone, and fludrocortisone for patient's subjective symptoms of orthostatic hypotension, and on objective autonomic testing
This study is completed, as verified in Jul 2005. You cannot join it, but the record below documents what was studied.
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Royal Brisbane and Women's Hospital