A Phase 4 interventional study of levodopa in Cerebrovascular Accident and Aphasia, sponsored by University Hospital Muenster. Completed at 1 site in Germany. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-10-07.
Sponsored by University Hospital Muenster · Phase 4, Interventional, and Treatment
The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether daily administration of levodopa, coupled with several hours of language training every day, will significantly improve naming abilities in patients with aphasia as compared to placebo administration. We furthermore examine with magnetic resonance imaging which brain regions need to be functionally intact for a dopaminergic improvement of language therapy.
365 studies on the registry are indexed under Aphasia; 89 are open to participants now.
This study's enrollment of 12 is below the median of 30 across 316 interventional studies indexed under Aphasia.
Browse Aphasia studies →University Hospital Muenster is the lead sponsor of 189 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria for patients with aphasia:
Exclusion Criteria for patients and healthy controls:
100mg levodopa per day over 10 days/ treatment phase
Boost in naming performance (percent correct) through levodopa as compared to placebo
Time frame: immediately after each treatmentphase
Brain activity pattern in successfully trained patients
Time frame: immediately after each treatmentphase
Stability of naming performance after one month and six months post treatment
Time frame: from 1 month untill 6 months after treatment completion
This study is completed, as verified in Jun 2008. You cannot join it, but the record below documents what was studied.
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University Hospital Muenster