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Status unknownNCT00071604Updated May 6, 2013

Medication Adherence in Older People With Psychosis

An interventional study of Medication Adherence Therapy and Friendly Support Group in Psychotic Disorders and Schizophrenia, sponsored by Veterans Medical Research Foundation. Status unknown at 1 site in United States. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2013-05-06.

Sponsored by Veterans Medical Research Foundation · Not applicable and Interventional

The sponsor has not verified this record recently (last verified Apr 2008), so the status shown — last known as Active, not recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
240
Allocation
Randomized
Ages
40 Years and older
Sex
All
01

Study summary

This study will determine whether Medication Adherence Therapy (MAT) can improve medication adherence and lower the risk of rehospitalization in older patients with psychosis.

Read the detailed description

Psychoses are among the most common and serious psychiatric disorders. Currently, the most effective treatment for psychoses involves the use of antipsychotic or neuroleptic medications. Unfortunately, pharmacologic regimens often do not achieve their goals because of poor medication adherence. Nonadherence to antipsychotic treatment is a considerable public health problem that leads to myriad clinical and economic burdens, including psychotic relapse, increased clinic and emergency room visits, and rehospitalization.

Participants in this study are randomly assigned to receive either MAT or supportive treatment for 12 weeks. MAT is given in 15 sessions and consists of motivational interviewing, education, and social skills and behavior modification. Individual MAT sessions are held in Weeks 1 and 12; small group sessions take place in Weeks 2 through 11. Three monthly booster group sessions begin in Week 16. Participants are assessed at baseline and at 3, 6, and 12 months. Medication adherence, psychopathology, quality of life, medication side effects, health beliefs, and functioning are assessed.

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Conditions studied

  • Psychotic Disorders
  • Schizophrenia
03

In context

Schizophrenia

3,471 studies on the registry are indexed under Schizophrenia; 472 are open to participants now.

This study's planned enrollment of 240 is above the median of 70 across 2,872 interventional studies indexed under Schizophrenia.

Browse Schizophrenia studies →

Lead sponsor

Veterans Medical Research Foundation is the lead sponsor of 43 studies on the registry; 9 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
40 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Inclusion Criteria:

  • DSM-IV criteria for schizophrenia or schizoaffective disorder
  • Outpatient status at the time of enrollment
  • Currently prescribed maintenance treatment with antipsychotic medication (typical or atypical, oral or depot)
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Study design

Phase
Not applicable
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double
Enrollment
240 participants (estimated)

Interventions

  • BehavioralMedication Adherence Therapy
  • BehavioralFriendly Support Group
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Study locations

1 site
  • Division of Geriatric Psychiatry Center (University of California, San Diego)
    San Diego, California 92161, United States
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References and documents

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 6, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00071604
Lead sponsor
Veterans Medical Research Foundation
Collaborators
National Institute of Mental Health (NIMH)
First posted
Oct 30, 2003
Start date
Sep 2002
Completion
May 2007
Last update
May 6, 2013

Study contacts

Jonathan Lacro, PharmD
principal investigator · VA San Diego Healthcare System & University of California, San Diego
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Apr 2008. You cannot join it, but the record below documents what was studied.

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