A Phase 2 interventional study of Test Drug and Placebo Drug in Heroin Dependence and Opioid-Related Disorders, sponsored by University of Colorado, Denver. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2017-05-04.
Sponsored by University of Colorado, Denver · Phase 2, Interventional, and Treatment
The purpose of this study is to assess the abuse liability and examine the reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in healthy, non-drug dependent volunteers.
not available at this time
Individuals must be healthy, non-drug dependent volunteers, be at least 18 years of age, and have no prior history of drug or alcohol abuse or dependence. Subjects must have had some minimal experience with opioids (e.g. at least two prior exposures)
Exclusion Criteria:
Individuals with evidence of an active Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Axis I psychiatric disorder (e.g. psychosis, manic-depressive illness, organic psychiatric disorders), significant medical illness (e.g., liver or cardiovascular disease) or pregnant female subjects are excluded from study participation.
Test drug to prevent heroine withdrawal
Drug: Test Drug
Placebo drug
Drug: Placebo Drug
Also known as: test drug o
Observed withdrawal rating
Pupil diameter
Drug effect characteristics
This study is withdrawn, as verified in May 2017. You cannot join it, but the record below documents what was studied.
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University of Colorado, Denver