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Status unknownNCT00033059Updated Jan 11, 2017

Assessment of Potential Interactions Between Cocaine and Tolcapone - 1

A Phase 1 interventional study of Tolcapone in Cocaine-Related Disorders, sponsored by National Institute on Drug Abuse (NIDA). Status unknown at 1 site in United States. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2017-01-11.

Sponsored by National Institute on Drug Abuse (NIDA) · Phase 1, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Aug 2003), so the status shown — last known as Active, not recruiting — may be out of date.
Phase
Phase 1
Study type
Interventional
Enrollment
16
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

The purpose of this study is to assess the potential interactions between intravenous (IV) cocaine and tolcapone.

Read the detailed description

Double-blind, inpatient study by screening responses to cocaine infusions of 20 and 40 mg i.v. subjects into 1 of 2 treatment groups to assess potential interactions between i.v. cocaine infusion and treatment with tolcapone.

02

Conditions studied

  • Cocaine-Related Disorders
03

In context

Cocaine-Related Disorders

415 studies on the registry are indexed under Cocaine-Related Disorders; 12 are open to participants now.

This study's enrollment of 16 is below the median of 60 across 312 interventional studies indexed under Cocaine-Related Disorders.

Browse Cocaine-Related Disorders studies →

Lead sponsor

National Institute on Drug Abuse (NIDA) is the lead sponsor of 388 studies on the registry; 19 are open to participants now.

Of its 12 completed or terminated interventional studies of FDA-regulated products, 5 (42%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

Volunteers dependent on cocaine and are non-treatment seeking; between 18-45 yrs of age; DSM-4 criteria for cocaine abuse or dependence

Exclusion criteria

Exclusion Criteria:

Additional criteria available during screening at the site

05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Masking
Double
Enrollment
16 participants

Interventions

  • DrugTolcapone
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What researchers measure

Primary outcomes

  1. Safety

07

Study locations

1 site
  • UCLA Integrated Substance Abuse Program
    Los Angeles, California 90024, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 11, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00033059
Lead sponsor
National Institute on Drug Abuse (NIDA)
First posted
Apr 8, 2002
Start date
Jul 2001
Completion
Mar 2002
Last update
Jan 11, 2017

Study contacts

Thomas Newton, M.D.
principal investigator · National Institute on Drug Abuse (NIDA)
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2003. You cannot join it, but the record below documents what was studied.

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Discussion

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National Institute on Drug Abuse (NIDA)

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