Integrative Skin Science and Research clinical trials
Also known as ISSR.
The registry lists 35 studies whose lead sponsor is Integrative Skin Science and Research. 12 are recruiting or about to start. Per ClinicalTrials.gov, last updated Aug 13, 2026.
Our grouping of 1 registry name, not the registry’s. See them and correct one ↓
- 35studies on the registry
- 12open to participants now
- 2reach primary completion within a year
Get an email when these change. Save the Integrative Skin Science and Research studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Pipeline: 2 programmes
Each counted once: 2 with a study Integrative Skin Science and Research leads registered in the last two years.
- Phase 4 (approved, new studies)
The 2 programmes — sign in to see the list, free: with every programme, filter by condition or phase and sort by first study or primary completion.
Not counted: 1 approved drug Integrative Skin Science and Research gives alongside its own in its studies — doxycycline (with sarecycline). Our rule: a drug many companies test, in every study Integrative Skin Science and Research led of it in the last two years beside a drug of its own.
Companies developing a programme in the same conditions as Integrative Skin Science and Research’s (2 conditions its studies of the last two years are mainly about), ranked by how directly they meet: a programme tested against the other’s drug, read from the study’s arms; then the conditions where both are in phase 3; then the conditions shared. Size plays no part.
- Sanofi2 conditions shared: Dermatitis, Atopic, Acne Vulgaris
- 3SBio Inc.2 conditions shared: Acne Vulgaris, Dermatitis, Atopic
- Galderma Group AG2 conditions shared: Acne Vulgaris, Dermatitis, Atopic
- Jiangsu HengRui Medicine Co., Ltd.1 condition shared: Dermatitis, Atopic
- AbbVie1 condition shared: Dermatitis, Atopic
| Company | Conditions shared | Their phase 3 there | Where they meet, by arms |
|---|---|---|---|
| Sanofi5 programmes in shared conditions | 2Dermatitis, Atopic, Acne Vulgaris | Dupilumab coformulated with berahyaluronidase alfa | no study of one against the other’s drug |
| 3SBio Inc.4 programmes in shared conditions | 2Acne Vulgaris, Dermatitis, Atopic | Clascoterone, camtarkibart | no study of one against the other’s drug |
| Galderma Group AG2 programmes in shared conditions | 2Acne Vulgaris, Dermatitis, Atopic | trifarotene, nemolizumab | no study of one against the other’s drug |
| Jiangsu HengRui Medicine Co., Ltd.5 programmes in shared conditions | 1Dermatitis, Atopic | drotokibart | no study of one against the other’s drug |
| AbbVie4 programmes in shared conditions | 1Dermatitis, Atopic | upadacitinib | no study of one against the other’s drug |
76 more companies — sign in to see them all, free.
Also leading studies of the same drugs, not counted as competitors (a partner, a licensee, a biosimilar maker, or a combination study): Arcutis Biotherapeutics, Inc. (Roflumilast).
“Registry” is the highest phase of Integrative Skin Science and Research’s own registered studies; Integrative Skin Science and Research’s own pipeline document is not read yet. “Primary completion” is the earliest date still ahead among its live studies when the main measure’s data collection ends, as the registry states it (most are estimates); results come later, if they are announced. Programmes are read from ClinicalTrials.gov, joined across names by rules and decisions each recorded with its evidence.
What it is testing
The drugs Integrative Skin Science and Research’s studies test, most open studies first — 8 drugs with a page of their own. Each count opens the studies in search.
Open now Not open: under way, finished or stopped
Coming up
2 of Integrative Skin Science and Research’s studies under way reach primary completion within a year. The dates are the sponsor’s own estimates, which often move.
Phase 3 Other phases
- NNov ’26’26
- DDec
- JJan ’27’27
- FFeb
- MMar
- 1AApr
- MMay
- JJun
- JJul
- 1AAug
- SSep
- OOct
- NNov
All 2
- Apr 2027Comparing Sarecycline and Doxycycline Effects on the Skin and Gut Bacteria in Acne.sarecycline, Doxycycline · NCT07544251
- Aug 2027Obtaining Descriptive Classifications of Pruritus and Assessing Change in Pruritus Over Time in Atopic Dermatitis Patients Using Topical Roflumilast Cream.Roflumilast · NCT07560618
Add all 2 to your calendar (.ics) → With an account.
All 35 at a glance
Where each study is in its life, its phase and its countries. Each count opens them in search.
Over the years
- 19
- 20
- 21
- 22
- 1623
- 24
- 25
- 226
By the year each study started. 2026 so far in the lighter column.
Registry sponsor names on this page
Our grouping. This page groups the registry's lead sponsor names by company — our grouping, not the registry's. It can be wrong or incomplete: an acquired company whose name never mentions its owner may be missing. Use “Something wrong?” under any name below to correct it.
Tell us about a missing company
Each name exactly as ClinicalTrials.gov lists it, and how it relates to Integrative Skin Science and Research.
- Integrative Skin Science and Research35 studiesSame company
Something wrong?
Studies
Recruiting first, then most recently updated. Showing 35 of 35.
- Obtaining Descriptive Classifications of Pruritus and Assessing Change in Pruritus Over Time in Atopic Dermatitis Patients Using Topical Roflumilast Cream.RecruitingNCT07560618Phase 4
- Comparing Sarecycline and Doxycycline Effects on the Skin and Gut Bacteria in Acne.RecruitingNCT07544251Phase 4
- The Effects of Topical Almond Oil and Tretinoin on Facial WrinklesRecruitingNCT06571721Not applicable
- Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in RosaceaRecruitingNCT06072066Not applicable
- The Use of Image-Based Computer Gradings in the Analysis of Acne, Rosacea, Melasma, and Seborrheic DermatitisRecruitingNCT05942248Not applicable
- The Effects of Almond on Facial Skin Collagen and WrinklesRecruitingNCT06074276Not applicable
- Correlation Between Objective Skin Pigment Measurement and Fitzpatrick Skin TypeRecruitingNCT06144541
- Effects of an Oral Herbal Supplement on Skin Aging, Hydration, and ElasticityNot yet recruitingNCT06146140Not applicable
- Assessment of the Effects of Silk Pillowcases on Acne Prone SkinNot yet recruitingNCT06142487Not applicable
- The Effects of Zinc Di-(Dibutyryl Lisinate) on Skin Health and the Skin Microbiome in Photoaged SkinNot yet recruitingNCT06096649Not applicable
- Study of Skin Balancing Gel Cream Safety and Influence of Skin Microbiome on Acne Prone SkinRecruitingNCT05941065Not applicable
- Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and ElasticityRecruitingNCT05882084Not applicable
- The Effects of Oral Probiotics and Herbal Supplementation on the Gut Microbiome and Sebum Excretion Rate in Non-Cystic AcneCompletedNCT05919810Not applicable
- The Effects of Cetyl Tranexamate Mesylate on the Appearance of Acne-Related HyperpigmentationCompletedNCT06080035Not applicable
- The Effects of an Oral Hair Supplement on Hair Density, Growth, and MicrobiomeActive, not recruitingNCT06146166Not applicable
- Prospective Study of Topical Adapinoid Versus Topical RetinolCompletedNCT05778760Not applicable
- The Effects of a Longevity Supplement on Aging and PhotoagingActive, not recruitingNCT05262036Not applicable
- Prospective Study of Topical Vitamin C (THDA) Versus Topical Vitamin C (THDA) With Acetyl ZingeroneActive, not recruitingNCT05779280Not applicable
- The Effects of a 5-Step Skin Regimen on Pigmentation and Appearance Related Biophysical PropertiesActive, not recruitingNCT05688527Not applicable
- The Effects of a 3-Part Skin Care Regimen on Facial Wrinkles and Biophysical AttributesStatus unknownNCT05698485Not applicable
- Assessment of the Effect of Coconut and Sunflower Seed Oil Derived Isosorbide Diseters and Colloidial OatmealStatus unknownNCT05688735Not applicable
- The Effects of Terminalia Chebula Fruit Extract on the Gut Microbiome and Skin Biophysical PropertiesCompletedNCT04597502Not applicable
- The Effect of Isosorbide Diesters Based Moisturizer on Skin HealthCompletedNCT04831892Not applicable
- Safety of Pulsing Heating Device Use on the SkinStatus unknownNCT05427877Not applicable
- A Botanical Skin Care Regimen on Mild to Moderate Acne and the MicrobiomeStatus unknownNCT05271487Not applicable
- Almond Supplementation on Mild to Moderate AcneStatus unknownNCT05269641Not applicable
- Effects of Dietary Soy Protein on Facial Wrinkles in Postmenopausal WomenStatus unknownNCT04871750Not applicable
- Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal WomenStatus unknownNCT04869852Not applicable
- Topical and Oral Regimen for Skin HealthCompletedNCT04872946Not applicable
- Botanical Blend on the Gut Microbiome and Gut-Skin-Axis in Small Intestinal Bacterial Overgrowth (SIBO)Status unknownNCT04867512Not applicable
- Oral Probiotics on the Shift in Gut Microbiome and Skin Carotenoid LevelsStatus unknownNCT04841694Not applicable
- The Effects of a Springtime Home Cleanse on Skin, Gut, Metabolic and Mental HealthStatus unknownNCT04869865Not applicable
- Oral Pomegranate Extract on the Microbiome and Skin Biophysical PropertiesCompletedNCT04596722Not applicable
- Oral Probiotics on the Microbiome and Lipidome in Acne VulgarisStatus unknownNCT04596748Not applicable
- Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for PhotoagingCompletedNCT04586816Not applicable