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CompletedNCT01493830Updated Jul 11, 2016

Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma

An observational study in Neuroblastoma, sponsored by Children's Oncology Group. Completed. Open to participants aged Up to 120 Years. Per ClinicalTrials.gov, last updated 2016-07-11.

Sponsored by Children's Oncology Group · Observational

Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
5
Ages
Up to 120 Years
Sex
All
01

Study summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies biomarkers in tumor samples from younger patients with neuroblastoma.

Read the detailed description

OBJECTIVES:

  • To determine the expression of UBE4B, hrs, and members of the ubiquitination protein complex in previously banked primary neuroblastoma tumor samples from the Children's Oncology Group.
  • To determine the correlation of expression levels and cellular localization of the UBE4B and hrs proteins with growth factor-receptor tumor cell-surface expression.
  • To determine the 1p36 deletion status by fluorescence in situ hybridization (FISH) analysis and their association with expression levels of UBE4B and hrs in previously banked primary neuroblastoma tumor samples from the Children's Oncology Group.

OUTLINE: Banked tumor tissue samples are analyzed for expression of UBE4B, hrs, members of the ubiquitination protein complex, growth factor receptors, and 1p36 deletion status by immunohistochemistry (IHC), fluorescent microscopy, and fluorescence in situ hybridization (FISH).

02

Conditions studied

  • Neuroblastoma

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Keywords

  • neuroblastoma
03

In context

Neuroblastoma

625 studies on the registry are indexed under Neuroblastoma; 122 are open to participants now.

This study's planned enrollment of 5 is below the median of 121 across 77 observational studies indexed under Neuroblastoma.

Browse Neuroblastoma studies →

Lead sponsor

Children's Oncology Group is the lead sponsor of 436 studies on the registry; 34 are open to participants now.

Of its 12 completed or terminated interventional studies of FDA-regulated products, 11 (92%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Up to 120 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients With Neuroblastoma

Eligibility criteria

DISEASE CHARACTERISTICS:

  • Tumor tissue microarrays from the Children's Oncology Group neuroblastoma tumor bank

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
05

Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
5 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Interventions

  • Geneticfluorescence in situ hybridization
  • Geneticgene expression analysis
  • Geneticmicroarray analysis
  • Geneticmutation analysis
  • Geneticprotein analysis
  • Otherimmunohistochemistry staining method
  • Otherlaboratory biomarker analysis
  • Othermicroscopy
06

What researchers measure

Primary outcomes

  1. Expression of UBE4B, hrs, and members of the ubiquitination protein complex

  2. Expression levels and cellular localization of the UBE4B, hrs, and growth factor receptors

  3. 1p36 deletion status and its association with UBE4B

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 11, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01493830
Lead sponsor
Children's Oncology Group
Collaborators
National Cancer Institute (NCI)
Responsible party
Sponsor
First posted
Dec 16, 2011
Start date
Dec 2011
Primary completion
Jul 2016
Last update
Jul 11, 2016

Study contacts

Peter Zage, MD, PhD
principal investigator · Texas Children's Cancer Center

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.

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