Zilovertamab vedotin clinical trials
Also written MK-2140 and VLS-101.
How each study uses zilovertamab vedotin is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Approvals
The first approval found in each region, with its record
- United States
- Not in FDA's approval records
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
10 studies that test it; most in 2022 (5)
| Year | Studies |
|---|---|
| 2019 | 1 |
| 2020 | 1 |
| 2022 | 5 |
| 2024 | 1 |
| 2025 | 2 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 10 · Other 0
Merck Sharp & Dohme LLC (8) · VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (2)
Often tested with
Tested in the same studies.
Anti-nectin-4 Antibody-drug Conjugate MK-3120 (1) · Gemcitabine (1) · Oxaliplatin (1) · Bendamustine (1)
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 1, 1 in phase 3
Studies that test zilovertamab vedotin, phase 3 first.
Studies
Open first, then newest update. How each study uses zilovertamab vedotin is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 10
- A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06717347Written as Zilovertamab vedotin
- A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)RecruitingPhase 2/3Merck Sharp & Dohme LLCNCT05139017Written as Zilovertamab vedotin
- A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)RecruitingPhase 2Merck Sharp & Dohme LLCNCT06890884Written as Zilovertamab vedotin
- Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT06395103Written as Zilovertamab vedotin
- A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)Active, not recruitingPhase 1/2Merck Sharp & Dohme LLCNCT05562830Written as Zilovertamab vedotin
- A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)Active, not recruitingPhase 2Merck Sharp & Dohme LLCNCT05458297Written as Zilovertamab vedotin
- A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004)CompletedPhase 2Merck Sharp & Dohme LLCNCT05144841Written as Zilovertamab vedotin
- A Study of Zilovertamab Vedotin (MK-2140/VLS-101) in Participants With Solid Tumors (MK-2140-002)TerminatedPhase 2VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT04504916Written as Zilovertamab vedotin
- A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)Active, not recruitingPhase 2Merck Sharp & Dohme LLCNCT05406401Written as Zilovertamab Vedotin
- A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)CompletedPhase 1VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)NCT03833180Written as Zilovertamab vedotin
Given beside what is tested · 1 — zilovertamab vedotin is usual care or a partner of the new treatment
Codes
What other systems call zilovertamab vedotin · ClinicalTrials.gg INT016884
- UNII (FDA) IZY9ZSI6FIZILOVERTAMAB VEDOTINOne source FDA
- NCI Thesaurus C157772Zilovertamab VedotinOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| UNII (FDA) | IZY9ZSI6FI | ZILOVERTAMAB VEDOTIN | One source FDA |
| NCI Thesaurus | C157772 | Zilovertamab Vedotin | One source FDA |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.