Serotonin and Noradrenaline Reuptake Inhibitors: all 504 studies that test it

Page 1 of 6. Open to participants first (35), then studies with results posted, then the rest; newest registration first within each.

• Personalized Analgesia Through Central Nervous System Engagement to Unlock PerformanceRecruitingNCT07759336Phase 4
• Venlafaxine for Non-specific Low Back PainNot yet recruitingNCT07737158Not applicable
• Algorithm-informed Decision-making to Advance Pain TreatmentRecruitingNCT07731750Not applicable
• Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)Not yet recruitingNCT07649291Phase 2
• Venlafaxine as Adjunct Therapy in Rheumatoid ArthritisNot yet recruitingNCT07497282Phase 2
• Duloxetine in Inflammatory Bowel DiseasesRecruitingNCT07431606Phase 2
• Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain SyndromeRecruitingNCT07421427Not applicable
• The Efficacy and Safety of Pregabalin Combined With Venlafaxine in Patients With FibromyalgiaRecruitingNCT07186751Not applicable
• The Efficacy and Safety of Pregabalin Combined With Desvenlafaxine in Patients With FibromyalgiaRecruitingNCT07171320Not applicable
• Evaluating the Safety and Efficacy of Duloxetine in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography PancreatitisRecruitingNCT06860984Phase 3
• Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCTRecruitingNCT06807866Phase 4
• Effect of Venlafaxine Versus Dosulepin in Pain Predominant Somatic Symptom DisorderRecruitingNCT06803485Phase 4
• SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.RecruitingNCT06614322Phase 2
• ADC-induced Neurotoxicity Treated With DuloxetineRecruitingNCT06551051Phase 2
• Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)RecruitingNCT06423716Phase 4
• Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Patients With Early Breast CancerNot yet recruitingNCT06407401Phase 3
• Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee OsteoarthritisRecruitingNCT06245109Phase 4
• Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic DisorderRecruitingNCT06232473Phase 4
• The Role of Negr1 In Modulating Neuroplasticity in Major Depression (RONIN)RecruitingNCT06131268Phase 4
• REDucing Hot FLASHes in Women Using Endocrine Therapy.RecruitingNCT06106529Phase 3
• Identifying and Treating Depression in the Orthopaedic Trauma PopulationRecruitingNCT05976347Phase 4
• The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.RecruitingNCT05973786Phase 3
• The Effect of Preoperative Duloxetine on the Occurance of Postoperative Delirium in Patients Undergoing Cancer Surgery.Not yet recruitingNCT05949229Phase 1/2
• Venlafaxine for Postoperative Pain of Laparoscopic CholecystectomyNot yet recruitingNCT05884268Phase 1/2
• Preventive Approach Using VenlafaxineRecruitingNCT05875610Phase 4
• Duloxetine for LBPRecruitingNCT05851976Phase 4
• Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility FracturesRecruitingNCT05851898Phase 4
• Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)RecruitingNCT05814640Phase 1/2
• Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment FailureRecruitingNCT05603104Phase 3
• Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related CoughRecruitingNCT05120934Phase 2
• Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic CoughRecruitingNCT05110144Phase 2
• Efficacy and Safety of Duloxetine in Chinese Solid Tumor Patients With Taxanes-induced Painful Peripheral NeuropathyRecruitingNCT04970121Phase 2
• Pragmatic Trial of Obsessive-compulsive DisorderRecruitingNCT04539951Phase 2
• Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)RecruitingNCT04245748Phase 4
• Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)RecruitingNCT04245436Phase 4
• The BEST Trial: Biomarkers for Evaluating Spine TreatmentsCompletedNCT05396014Phase 4Results posted
• The Back Pain Consortium Research Program StudyCompletedNCT04870957Phase 4Results posted
• Antidepressant Response in Older Adults With Comorbid PTSD and MDDTerminatedNCT04697693Phase 4Results posted
• Combination Drug-Therapy for Patients With Untreated Obstructive Sleep ApneaCompletedNCT04639193Phase 2Results posted
• A Study of MD-120 in Patients With DepressionCompletedNCT04345471Phase 3Results posted
• Assessing the Efficacy of a Serotonin and Norepinephrine Reuptake Inhibitor for Improving Meniere's Disease OutcomesCompletedNCT04218123Phase 2/3Results posted
• The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI StudyCompletedNCT03588572Not applicableResults posted
• Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)CompletedNCT03575403Phase 1Results posted
• Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation TherapyCompletedNCT03574792Phase 2Results posted
• Efficacy, Safety, and Tolerability of Levomilnacipran ER in Pediatric Patients (7-17 Years) With Major Depressive DisorderCompletedNCT03569475Phase 3Results posted
• Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care RandomizationCompletedNCT03548454Phase 4Results posted
• A Study of Duloxetine (LY248686) in the Treatment of Japanese Children and Adolescents With Depressive DisorderTerminatedNCT03395353Phase 3Results posted
• A Study of Duloxetine (LY248686) in Japanese Children and Adolescents With Depressive DisorderCompletedNCT03315793Phase 3Results posted
• Effect of Duloxetine on Opioid Use After Total Knee ArthroplastyCompletedNCT03271151Phase 4Results posted
• Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response (NEMO)CompletedNCT03128021Phase 4Results posted
• Impact of Duloxetine on Male FertilityCompletedNCT03038867Phase 2Results posted
• Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRDCompletedNCT02977299Phase 4Results posted
• Brain Morphometry in OA Patients Treated With DuloxetineCompletedNCT02903238Not applicableResults posted
• Levomilnacipran ER vs. Adjunctive Quetiapine for Adults With Inadequate Relief With SSRIs in MDDCompletedNCT02720198Phase 3Results posted
• The Impact of Venlafaxine on Apnea Hypopnea Index in Obstructive Sleep ApneaCompletedNCT02714400Phase 4Results posted
• Uncovering Neural and Immune Mechanisms of Chronic Pain in Post Treatment Lyme SyndromeTerminatedNCT02687165Not applicableResults posted
• A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and ComorbidityCompletedNCT02655354Not applicableResults posted
• Trial of Levomilnacipran in Geriatric DepressionCompletedNCT02466958Phase 4Results posted
• Safety and Efficacy of Levomilnacipran ER in Adolescent Participants With Major Depressive DisorderCompletedNCT02431806Phase 3Results posted
• A Study of Duloxetine (LY248686) in Participants With Diabetic Peripheral Neuropathic Pain (DPNP)CompletedNCT02417935Phase 4Results posted
• An Extension Study of Duloxetine in Osteoarthritis and Knee Pain (Extension of F1J-JE-HMGX, NCT02248480)CompletedNCT02335346Phase 3Results posted
• A Multicenter, Relapse Prevention Study With Levomilnacipran Extended Release (ER) in Participants With Major Depressive DisorderCompletedNCT02288325Phase 4Results posted
• Novel Medication as a Potential Smoking Cessation AidCompletedNCT02265367Not applicableResults posted
• Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life SituationsCompletedNCT02260388Phase 4Results posted
• A Study of Duloxetine (LY248686) in Participants With Chronic Osteoarthritis and Knee Pain in JapanCompletedNCT02248480Phase 3Results posted
• Study to Assess Clinical Response of Duloxetine in Patients Hospitalized for Severe DepressionCompletedNCT02229825Phase 4Results posted
• Does Duloxetine Reduce Sub-Acute Pain After Knee Arthroplasty?CompletedNCT02005601Phase 4Results posted
• A Study of Duloxetine in Participants With Chronic Pain Due to Osteoarthritis in ChinaCompletedNCT01931475Phase 3Results posted
• An Open Label Extension Study of Duloxetine (LY248686) in Participants With Chronic Low Back PainCompletedNCT01914666Phase 3Results posted
• Mechanistic Study of Duloxetine in Breast Cancer Patients With Chronic PainCompletedNCT01912612Phase 2Results posted
• A Study of Duloxetine (LY248686) in Participants With Chronic Low Back PainCompletedNCT01855919Phase 3Results posted
• Duloxetine Treatment in Elderly With DysthymiaCompletedNCT01852383Phase 4Results posted
• Research Examining Gulf War Illness in Our Nations Service MembersTerminatedNCT01846182Phase 2Results posted
• Milnacipran and Neurocognition, Pain and Fatigue in Fibromyalgia : A 13-week Randomized, Placebo Controlled Cross Over TrialCompletedNCT01829243Phase 3Results posted
• Open-label Milnacipran for Persistent Knee Pain One Year After Total Knee Arthroplasty (TKA)CompletedNCT01780389Phase 4Results posted
• Milnacipran for Lumbosacral Radicular PainCompletedNCT01777581Phase 4Results posted
• Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major DepressionCompletedNCT01754493Phase 4Results posted
• Combination Treatment Study for Memory Impairment and DepressionCompletedNCT01658228Phase 4Results posted
• An Extension Study of Duloxetine in Fibromyalgia (Extension of F1J-JE-HMGZ, NCT01552057)CompletedNCT01621191Phase 3Results posted
• Venlafaxine in Preventing Chronic Oxaliplatin-Induced Neuropathy In Patients Receiving Combination ChemotherapyCompletedNCT01611155Not applicableResults posted
• Venlafaxine for Depression in Alzheimer's Disease (DIADs-3)CompletedNCT01609348Not applicableResults posted
• S1202: Duloxetine Hydrochloride for Muscle/Joint Pain in Early-Stage Breast Cancer Receiving Hormone TherapyCompletedNCT01598298Phase 3Results posted
• Duloxetine in Osteoarthritis (OA) PainCompletedNCT01558700Phase 4Results posted
• A Study of Duloxetine in FibromyalgiaCompletedNCT01552057Phase 3Results posted
• Desvenlafaxine vs. Placebo Treatment of Chronic DepressionCompletedNCT01537068Phase 4Results posted
• Quality of Life Study Using Gabapentin Versus Venlafaxine in Treating Hot Flashes in Patients With Prostate CancerTerminatedNCT01533753Phase 2Results posted
• Milnacipran for Chronic Pain in Knee OsteoarthritisCompletedNCT01510457Phase 4Results posted
• Venlafaxine ER Long-Term Extension Study for Major Depressive Disorder (MDD)CompletedNCT01485887Phase 3Results posted
• Milnacipran (Savella) in Irritable Bowel Syndrome (IBS)TerminatedNCT01471379Phase 2Results posted
• Duloxetine for the Treatment of Chronic Pelvic PainTerminatedNCT01451606Phase 4Results posted
• Venlafaxine ER Phase 3 Study for Major Depressive Disorder (MDD)CompletedNCT01441440Phase 3Results posted
• Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) in Adult Outpatients With Major Depressive Disorder (MDD)CompletedNCT01432457Phase 4Results posted
• MsFLASH-03: Comparative Efficacy of Low-Dose Estradiol and Venlafaxine XR for Treatment of Menopausal SymptomsCompletedNCT01418209Not applicableResults posted
• Study Evaluated the Effectiveness of Milnacipran to Reduce Pain Levels in Individuals With Chronic MigraineCompletedNCT01393522Not applicableResults posted
• Safety and Efficacy of Levomilnacipran ER (Levomilnacipran SR) in Major Depressive DisorderCompletedNCT01377194Phase 3Results posted
• A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDDCompletedNCT01372150Phase 3Results posted
• Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of AutismCompletedNCT01337700Phase 4Results posted
• Long-Term Safety and Efficacy Study of Milnacipran in Pediatric Patients With Primary FibromyalgiaTerminatedNCT01331109Phase 2Results posted
• Safety and Efficacy of Milnacipran in Pediatric Patients With Primary FibromyalgiaTerminatedNCT01328002Phase 2Results posted
• 12-Week Study of Pristiq (Desvenlafaxine) Social Anxiety DisorderCompletedNCT01316302Phase 4Results posted

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