Protein Kinase Inhibitors: all 15,147 studies that test it
Page 131 of 152. Open to participants first (2,533), then studies with results posted, then the rest; newest registration first within each.
- An Absorption, Distribution, Metabolism and Excretion (ADME) Study of Single Oral Dose [14C] GSK2118436 in Subjects With BRAF Mutant Solid TumorsCompletedNCT01262963Phase 1
- Cediranib as Palliative Treatment in Patients With Symptomatic Malignant Ascites or Pleural EffusionTerminatedNCT01262612Phase 2
- Study of Oxaliplatin and Sorafenib Combination to Treat Gastric Cancer Relapsed After a Cisplatin Based TreatmentCompletedNCT01262482Phase 2
- Evaluating Lapatinib + Capecitabine in Patients Aged 70 and Over With HER2 Metastatic Breast Cancer.CompletedNCT01262469Phase 2
- A Dose Finding Study of TKM-080301 Infusion in Neuroendocrine Tumors (NET) and Adrenocortical Carcinoma (ACC) PatientsCompletedNCT01262235Phase 1/2
- Clinical Trial Investigating Pazopanib in Patients With Platinum-resistant Advanced Ovarian CancerCompletedNCT01262014Phase 2
- Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
- Clinical Study of Sorafenib and Zoledronic Acid to Treat Advanced HCCStatus unknownNCT01259193Phase 2
- Carboplatin/Taxol/Ridaforolimus in Endometrial, Ovarian and SolidsCompletedNCT01256268Phase 1
- A Study of AMG 337 in Subjects With Advanced Solid TumorsCompletedNCT01253707Phase 1
- Phase 1 and 2 Study of PX-866 and CetuximabCompletedNCT01252628Phase 1/2
- Nilotinib for Cytomegalovirus Prophylaxis and Treatment After Allogeneic Hematopoietic Stem Cell TransplantationCompletedNCT01252017Phase 2
- A Study of ARQ 197 in Combination With ErlotinibCompletedNCT01251796Phase 1
- Combination With Gemcitabine in Advanced Pancreatic CancerCompletedNCT01251640Phase 1/2
- BIBF 1120 in Recurrent Glioblastoma MultiformeCompletedNCT01251484Phase 2
- Hepatocellular Carcinoma (HCC)_Torisel_CompletedNCT01251458Phase 1/2
- Formulation Comparison in Normal VolunteersCompletedNCT01250197Phase 1
- Nasopharyngeal Carcinoma (NPC) AxitinibCompletedNCT01249547Phase 2
- MK-2206 for Recurrent Malignant GliomaWithdrawnNCT01249105Phase 2
- Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK2126458 and GSK1120212 Combination Therapy in Subjects With Advanced Solid Tumors.TerminatedNCT01248858Phase 1
- PhIb BKM120 or BEZ235+Endocrine Treatment in Post-Menopausal Patients With Hormone Receptor + Metastatic Breast CancerCompletedNCT01248494Phase 1
- A Randomized, Double Blind Study Evaluating Paclitaxel With and Without RAD001 in Patients With Gastric Carcinoma After Prior ChemotherapyCompletedNCT01248403Phase 3
- Temsirolimus-RCC-imagingStatus unknownNCT01246817Phase 2
- A Study of Fostamatinib in Subjects With Impaired Kidney FunctionCompletedNCT01245790Phase 1
- A Phase 0 of Neoadjuvant Lapatinib in Infiltrative Bladder Carcinoma Before CystectomyTerminatedNCT01245660Early Phase 1
- Akt Inhibitor MK2206 in Combination With Lapatinib Ditosylate in Patients With Advanced or Metastatic Solid Tumors or Breast CancerCompletedNCT01245205Phase 1
- Study of FP-1039 in Subjects With Endometrial CancersWithdrawnNCT01244438Phase 2
- Sunitinib Malate and Bevacizumab in Treating Patients With Kidney Cancer or Advanced Solid MalignanciesCompletedNCT01243359Phase 1
- Study of Crenolanib for the Treatment of Patients With Advanced GIST With the D842-related Mutations and Deletions in the PDGFRA GeneCompletedNCT01243346Phase 2
- Everolimus for Patients With Relapsed/Refractory Germ Cell CancerCompletedNCT01242631Phase 2
- ABC-04 a Study of Cisplatin, Gemcitabine and Selumetinib in Patients With Advanced Biliary Tract CancerCompletedNCT01242605Phase 1
- Trial of MK-2206 + Endocrine Treatment in Patients With Hormone Receptor Positive Breast CancerWithdrawnNCT01240941Phase 2
- Exploratory Study of XL765 (SAR245409) or XL147 (SAR245408) in Subjects With Recurrent Glioblastoma Who Are Candidates for Surgical ResectionCompletedNCT01240460Phase 1
- E7080 Food Effect Study in Healthy SubjectsCompletedNCT01240408Phase 1
- A Study to Determine the Relative Bioavailability of a Tablet Formulation of GDC-0941 and the Effect of Ketoconazole on the Pharmacokinetics of the GDC-0941 TabletCompletedNCT01240226Phase 1
- Study of SGI-1776, a PIM Kinase Inhibitor, in Subjects With Relapsed/Refractory LeukemiasWithdrawnNCT01239108Phase 1
- Phase I/II Study of Pazopanib and Cyclophosphamide in Patients With Platinum-resistant Recurrent Ovarian CancerCompletedNCT01238770Phase 1/2
- Sunitinib + Docetaxel as Second-line Treatment in Gastric CancerCompletedNCT01238055Phase 2
- Dose Finding Study for Combination of Capecitabine, Lapatinib and Vinorelbine in Metastatic Breast CancerTerminatedNCT01238029Phase 1
- A Trial of LEE011 in Patients With Advanced Solid Tumors or Lymphoma.CompletedNCT01237236Phase 1
- Extension Study Evaluating the Long Term Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)CompletedNCT01236638Phase 2
- A Trial to Establish the Feasibility of Combining Either the Tyrosine Kinase Inhibitor AC220,CXCR4 Inhibitor Plerixafor or HSP90 Inhibitor Ganetespib With Chemotherapy in Older Patients With Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome.CompletedNCT01236144Phase 1/2
- A Phase 1b, Open-label, Dose-finding Study of AMG 706 in Combination With Gemcitabine and Erlotinib to Treat Subjects With Solid TumorsCompletedNCT01235416Phase 1
- IGF-1 Inhibitor Pasireotide Lar in Combination With the m-TOR Inhibitor EverolimusWithdrawnNCT01234974Phase 2
- Dasatinib and Gemcitabine Hydrochloride or Gemcitabine Hydrochloride Alone in Treating Patients With Pancreatic Cancer Previously Treated With SurgeryCompletedNCT01234935Phase 2
- A Study of Ridaforolimus (MK-8669) in Combination With Dalotuzumab (MK-0646) Compared to Standard of Care Treatment in Estrogen Receptor Positive Breast Cancer Patients (MK-8669-041 AM3)CompletedNCT01234857Phase 2
- Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain MetastasesCompletedNCT01234740Phase 1
- Bosutinib In Subjects With Renal ImpairmentCompletedNCT01233882Phase 1
- MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or LeukemiaCompletedNCT01231919Phase 1
- Carboplatin and Paclitaxel With or Without Cediranib Maleate in Treating Patients With Metastatic or Recurrent Cervical Cancer That Cannot Be Removed by SurgeryCompletedNCT01229930Phase 2
- Avastin and Chemotherapy Followed by a KRAS Stratified Randomization to Maintenance Treatment for First Line Treatment of Metastatic Colorectal Cancer.CompletedNCT01229813Phase 3
- Study of Crenolanib, a Selective and Potent Inhibitor of PDGFR, for the Treatment of Adult GliomasTerminatedNCT01229644Phase 2
- A Study Comparing Imatinib and Imatinib/Pegylated Interferon in Chronic Myeloid LeukemiaCompletedNCT01227356Phase 2
- Imatinib Mesylate With or Without Hydroxychloroquine in Treating Patients With Chronic Myeloid LeukemiaStatus unknownNCT01227135Phase 2
- Ursodeoxycholic Acid And Cholestasis Of PregnancyWithdrawnNCT01226823Phase 3
- A Study Of Tasocitinib In Dry Eye SubjectsWithdrawnNCT01226680Phase 2
- Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment SchedulesCompletedNCT01226316Phase 1
- Sorafenib in Combination With RAD001 in Advanced Solid Tumors Selected on Molecular TargetsSuspendedNCT01226056Phase 1/2
- Dose Escalation Study of ARQ 736 in Adult Subjects With Advanced Solid Tumors Harboring BRAF and/or NRAS MutationsCompletedNCT01225536Phase 1
- A Study of Linifanib (ABT-869) in Combination With Carboplatin/Paclitaxel in Japanese Subjects With Non-Small Cell Lung Cancer (NSCLC)CompletedNCT01225302Phase 1
- Single and Multiple Oral Administration Study of ASP015K in Healthy Nonelderly VolunteersCompletedNCT01225224Phase 1
- A Food Effect and QTc Study of Perifosine in Patients With Advanced MalignanciesCompletedNCT01224730Phase 1
- To Evaluate the Effects of Multiple Doses of Nilotinib on the Pharmacokinetics and Metabolism of Midazolam in CML Patients With Additional Extension Phase to Evaluate the Safety of NilotinibCompletedNCT01223898Phase 1
- Sirolimus In Autosomal Dominant Polycystic Kidney Disease And Severe Renal InsufficiencyTerminatedNCT01223755Phase 2/3
- Cisplatin, Gemcitabine Hydrochloride, and Sorafenib Tosylate in Treating Patients With Transitional Cell Cancer of the BladderStatus unknownNCT01222676Phase 2
- Study of CH5132799 Administered Orally in Patients With Advanced Solid TumorsCompletedNCT01222546Phase 1
- A Study of Fostamatinib in Subjects With Impaired Hepatic (Liver) FunctionCompletedNCT01222455Phase 1
- Safety and Efficacy Study of Nilotinib Combined With Mitoxantrone, Etoposide, and High-dose Cytarabine Induction Chemotherapy Followed by Consolidation for Patients With C-kit Positive Acute Myeloid LeukemiaTerminatedNCT01222143Phase 1/2
- Study for Safety and Efficacy Evaluation of Imatinib Mesylate in Children With Acute Lymphoblastic Leukemia (ALL) Philadelphia Chromosome-positive (Ph+)SuspendedNCT01222013Phase 2
- Pazopanib/DCE-MRIs in Renal Cell Carcinoma (RCC)CompletedNCT01221506Early Phase 1
- Phase II Study for Safety and Efficacy Evaluation of Imatinib Mesylate in Children With Chronic Myeloid Leukemia (CML) Philadelphia Chromosome-positive (Ph+)Status unknownNCT01221376Phase 2
- Study of Erlotinib (Tarceva®) in Combination With OSI-906 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) GeneCompletedNCT01221077Phase 2
- Determining the Maximum Tolerated Dose of Low Dose Interferon-alpha in Conjunction With Nilotinib in Pretreated Philadelphia Chromosome Positive (Ph+) Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP)CompletedNCT01220648Phase 1
- The Growth Factor Signature (GFS) as an Intermediate Biomarker of Response for Development of PI3K-Pathway Inhibitors in Patients With Breast Cancer (MK-8669-050)CompletedNCT01220570Phase 1
- A Study Combining LY2157299 With Temozolomide-based Radiochemotherapy in Patients With Newly Diagnosed Malignant GliomaCompletedNCT01220271Phase 1/2
- Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell CarcinomaStatus unknownNCT01219751Phase 2
- A Study of BYL719 in Adult Patients With Advanced Solid Malignancies, Whose Tumors Have an Alteration of the PIK3CA GeneCompletedNCT01219699Phase 1
- A Phase I Study of AZD1480 in Patients With Advanced Solid Malignancies and Advanced Hepatocellular Carcinoma in the Escalation Phase,Non-Small Cell Lung Cancer(NSCLC) and Non-smokers With Lung Metastasis and Gastric Cancer and Solid Tumour in the Expansion Phase.TerminatedNCT01219543Phase 1
- Lapatinib and WBRT for Patients With Brain Metastases From Lung or Breast TumorsCompletedNCT01218529Phase 2
- Sequential Two-agent Assessment in Renal Cell Carcinoma Therapy: The START TrialActive, not recruitingNCT01217931Phase 2
- Erlotinib as Neoadjuvant Treatment in Patients With Stage ⅢA N2 NSCLC With Activating EGFR Mutation.CompletedNCT01217619Phase 2
- Selumetinib and Cetuximab in Treating Patients With Refractory Solid TumorsCompletedNCT01217450Phase 1
- A Study of mTOR Inhibitor Everolimus (RAD001) in Association With Cisplatin and Radiotherapy for Locally Advanced Cervix CancerCompletedNCT01217177Phase 1
- Rapamycin In Angiomyolipomas In Patients With Tuberous SclerosisCompletedNCT01217125Phase 4
- Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Rhabdomyosarcoma and Other Soft Tissue SarcomasStatus unknownNCT01216839Phase 2
- Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed OsteosarcomaStatus unknownNCT01216826Phase 2
- Trial of Single Agent Sunitinib for Patients With Chemo-refractory Metastatic MelanomaTerminatedNCT01216657Phase 2
- Resection of Pulmonary Metastasis in Clear Cell Renal Cell Carcinoma +/-Adjuvant Sunitinib Therapy (SMAT)TerminatedNCT01216371Phase 2
- An Exploratory Study of High-dose Glivec in Patients With CML-CP Using Molecular EndpointsCompletedNCT01216085Phase 2
- Study of Bafetinib (INNO-406) as Treatment for Patients With Hormone-Refractory Prostate CancerCompletedNCT01215799Phase 2
- Predictive Biomarkers of Response to Sunitinib in the Treatment of Poorly-differentiated NEURO-Endocrine TumorsTerminatedNCT01215578Phase 2
- Study of Sunitinib in Patients With Advanced/Inoperable Fibrolamellar CarcinomaTerminatedNCT01215565Phase 2
- Sorafenib in Urothelium Cancer of BladderTerminatedNCT01215266Phase 2
- Comparing Efficacy of Sorafenib Versus Sorafenib in Combination With Low-dose FP in Patients With Advanced HCCStatus unknownNCT01214343Phase 3
- Study to Assess Safety and Tolerability of AZD4547 in Japanese PatientCompletedNCT01213160Phase 1
- Standard Chemotherapy With of Without Axitinib in Malignant MesotheliomaCompletedNCT01211275Phase 1/2
- A Cardiac Safety Study of Tivozanib to Evaluate the Electrocardiogram and Pharmacokinetic-Electrocardiogram Dynamics in Subjects With Advanced Solid TumorsCompletedNCT01210846Phase 1
- Sunitinib as Maintenance Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung CancerStatus unknownNCT01210053Phase 2
- Study in Healthy Males to Assess Bioavailability of 4 Different Fostamatinib TabletsCompletedNCT01208155Phase 1
- Pazopanib Hydrochloride or a Placebo in Treating Patients With Non-Small Cell Lung Cancer Who Have Received First-Line ChemotherapyTerminatedNCT01208064Phase 2/3