Protease Inhibitors: all 1,856 studies that test it

Page 7 of 19. Open to participants first (69), then studies with results posted, then the rest; newest registration first within each.

• TMC125-TiDP2-C238: An Exploratory Pharmacokinetics, Safety and Anti-HIV Activity Study of Etravirine (ETR) When Given With Boosted Atazanavir (ATV/Rtv) at Two Different Doses and 1 Nucleoside Reverse Transcriptase Inhibitor (NRTI) in Treatment Experienced HIV PatientsCompletedNCT00896051Phase 2Results posted
• A Study of IXAZOMIB in Adult Patients With LymphomaCompletedNCT00893464Phase 1Results posted
• Intrahepatic HCV RNA and Telaprevir Kinetics in Hepatitis C Virus (HCV)CompletedNCT00892697Phase 2Results posted
• Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV InfectionCompletedNCT00885664Phase 4Results posted
• Atazanavir and Lamivudine for Treatment SimplificationCompletedNCT00885482Phase 4Results posted
• A Study to Evaluate the Safety, Tolerability, and Efficacy of Odanacatib (MK-0822) in Postmenopausal Women Previously Treated With a Bisphosphonate (MK-0822-042)CompletedNCT00885170Phase 2Results posted
• A Study of TMC435 in Combination With Pegylated Interferon Alp\Fa-2a and Ribavirin in Patients Infected With Genotype 1 Hepatitis C Virus Who Never Received TreatmentCompletedNCT00882908Phase 2Results posted
• A Study of Safety and Efficacy of Vaniprevir Administered With Pegylated-Interferon and Ribavirin in Japanese Participants With Chronic Hepatitis C Infection (7009-016)CompletedNCT00880763Phase 2Results posted
• Safety and Efficacy of Daclatasvir (BMS-790052) Plus Standard of Care (Pegylated-interferon Alpha and Ribavirin)CompletedNCT00874770Phase 2Results posted
• Impact of Menstrual Cycle on Antiretroviral Pharmacokinetics in Healthy WomenCompletedNCT00869960Phase 4Results posted
• Single-Dose Pharmacokinetics of BMS-790052 in Participants With Hepatic ImpairmentCompletedNCT00859053Phase 1Results posted
• HIV Viremia and Persistence in Acutely HIV-Infected Patients Treated With Darunavir/Ritonavir and EtravirineTerminatedNCT00855413Phase 4Results posted
• A Single-arm, Open-label, Study to Assess the Pharmacokinetics of Darunavir and Ritonavir, Darunavir and Cobicistat, Etravirine, and Rilpivirine in HIV-1 Infected Pregnant WomenCompletedNCT00855335Phase 3Results posted
• A Study of the Safety and Immunogenicity of Repeated rhC1INH AdministrationCompletedNCT00851409Phase 2Results posted
• A Study to Determine the Antiviral Activity of TMC310911 When Administered With Ritonavir in Treatment-Naive Human Immunodeficiency Virus - Type 1 (HIV-1) Infected PatientsCompletedNCT00838162Phase 2Results posted
• Drug Interactions Between Voriconazole and Atazanavir Coadministered as Atazanavir/Ritonavir in Healthy ParticipantsCompletedNCT00833482Phase 1Results posted
• A Phase 1 Study of IXAZOMIB in Adult Patients With Advanced Nonhematologic MalignanciesCompletedNCT00830869Phase 1Results posted
• Safety and Effectiveness of Raltegravir Plus Darunavir/Ritonavir in Treatment-Naive HIV-Infected AdultsCompletedNCT00830804Phase 2Results posted
• A Study to Assess the Anti-viral Activity, Safety, Tolerability and Pharmacokinetics of TMC435350 in Participants Infected With Hepatitis C-Virus (HCV)CompletedNCT00812331Phase 2Results posted
• Comparative Study of Three NNRTI-Sparing HAART RegimensCompletedNCT00811954Phase 3Results posted
• Lopinavir/Ritonavir (Kaletra) PK in ChildrenCompletedNCT00810108Phase 4Results posted
• An Interaction Study to Assess Drug Levels in Fasting Healthy Adult SubjectsCompletedNCT00802074Not applicableResults posted
• Safety, Antiviral Activity and PK of MRD of BI 201335 in Chronic Hepatitis C Patients Both Treatment Naive and -ExperiencedCompletedNCT00793793Phase 1Results posted
• Study to Evaluate Using Nelfinavir With Chemoradiation for Non-small Cell Lung CancerTerminatedNCT00791336Phase 2Results posted
• Efficacy and Safety of MP-424, Peginterferon Alfa-2b and Ribavirin in Chronic Hepatitis C Who Have Not Achieved an Undetectable HCV RNA Level With Previous Interferon Based TherapyCompletedNCT00781274Phase 3Results posted
• Efficacy and Safety of MP-424, Peginterferon Alfa-2b, and Ribavirin in Patients With Chronic Hepatitis C Who Relapsed After Previous Interferon Based TherapyCompletedNCT00780910Phase 3Results posted
• Efficacy and Safety of MP-424/Peginterferon Alfa-2b/Ribavirin Combination in Treatment-Naïve Patients With Chronic Hepatitis CCompletedNCT00780416Phase 3Results posted
• Immune Reconstitution of Lopinavir/Ritonavir-Based vs Efavirenz-based HAART in Advanced HIV DiseaseTerminatedNCT00775606Phase 4Results posted
• A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With BronchiectasisCompletedNCT00769119Phase 2Results posted
• An Interaction Study to Assess Drug Levels in Healthy Adult SubjectsCompletedNCT00764465Phase 2Results posted
• Raltegravir vs. Atazanavir in Combination With Truvada® for the Treatment of Antiretroviral naïve HIV Infected PatientsCompletedNCT00762892Phase 4Results posted
• Effects of LY450139, on the Progression of Alzheimer's Disease as Compared With PlaceboCompletedNCT00762411Phase 3Results posted
• Comparison of Liquid Kaletra and Low Dose Kaletra TabletsCompletedNCT00762320Not applicableResults posted
• A Study Evaluating 24-Week and 48-Week Telaprevir-Based Regimen in Treatment Naïve Subjects With Genotype 1 Chronic Hepatitis C Who Achieve an Extended Rapid Viral ResponseCompletedNCT00758043Phase 3Results posted
• A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Cystic FibrosisCompletedNCT00757848Phase 2Results posted
• Changes in Triglyceride and Other Lipids (Levels of Fats Found in Blood) When Taking Darunavir Compared to Atazanavir in HIV-infected Patients That Have Never Received TreatmentCompletedNCT00757783Phase 4Results posted
• Lopinavir/r or Fosamprenavir/r Switch to Atazanavir/r or Darunavir/rCompletedNCT00756730Phase 4Results posted
• Study Of MK-0752 In Combination With Tamoxifen Or Letrozole to Treat Early Stage Breast CancerCompletedNCT00756717Phase 4Results posted
• Raltegravir + Lopinavir/Ritonavir Versus Efavirenz + Tenofovir + Emtricitabine in Treatment Naive PatientsCompletedNCT00752856Phase 2Results posted
• The Acute Effects of the Angiotensin-converting Enzyme Inhibitor Enalaprilat on Flow DistributionCompletedNCT00741156Phase 3Results posted
• Study to Evaluate Efficacy of Odanacatib (MK-0822) on Bone Mineral Density (BMD) and Bone Micro-architecture and Overall Safety in Postmenopausal Women (MK-0822-031)CompletedNCT00729183Phase 3Results posted
• Safety and Efficacy of Vaniprevir (MK-7009) With Pegylated Interferon (Peg-IFN) and Ribavirin (RBV) in Treatment-Experienced Hepatitis C Virus (HCV) Participants (MK-7009-009)CompletedNCT00704405Phase 2Results posted
• Safety and Efficacy of Vaniprevir (MK7009) Administered With Pegylated-Interferon and Ribavirin (MK-7009-007)CompletedNCT00704184Phase 2Results posted
• A Two Week Study to Assess the Tolerability of AZD9668 in Chronic Obstructive Pulmonary Disease (COPD) PatientsCompletedNCT00703391Phase 2Results posted
• Kaletra-isentress Treatment EvaluationCompletedNCT00700115Phase 4Results posted
• Three-year Follow-up of Participants After Administration of Boceprevir or Narlaprevir for the Treatment of Chronic Hepatitis C (P05063)TerminatedNCT00689390Phase 2/3Results posted
• Kaletra and Viread in Antiretroviral Naïve PatientsTerminatedNCT00679926Phase 4Results posted
• Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye DiseaseCompletedNCT00667004Phase 2Results posted
• A Multiple Ascending Dose Study of Daclatasvir (BMS-790052) in Hepatitis C Virus Genotype 1 Infected SubjectsCompletedNCT00663208Phase 2Results posted
• Raltegravir + Lopinavir/Ritonavir or Emtricitabine/Tenofovir for HIV Treatment Naive SubjectsCompletedNCT00654147Phase 2Results posted
• Drug Interaction StudyCompletedNCT00646776Phase 1Results posted
• Phase I/II Study of MK-0752 Followed by Docetaxel in Advanced or Metastatic Breast CancerCompletedNCT00645333Phase 1/2Results posted
• Genetic Predictors of Variability in the Drug-drug Interaction Between Darunavir/Ritonavir and PravastatinCompletedNCT00630734Phase 4Results posted
• A Phase 1 Study of MP-424, Peginterferon Alfa 2b, and Ribavirin in Hepatitis CCompletedNCT00630058Phase 1Results posted
• A Phase 3 Study of Telaprevir in Combination With Pegasys® and Copegus® in Treatment-Naive Subjects With Genotype 1 Hepatitis C Virus (HCV)CompletedNCT00627926Phase 3Results posted
• A Study of Invirase (Saquinavir)/Ritonavir in HIV-Infected Infants and Children.CompletedNCT00623597Phase 2Results posted
• Safety and Efficacy of MP-424 to Treat Chronic Hepatitis CCompletedNCT00621296Phase 2Results posted
• Efficacy and Safety of Odanacatib (MK-0822) in Participants With Involutional Osteoporosis (MK-0822-022)CompletedNCT00620113Phase 2Results posted
• An Interaction Study to Assess Drug Levels in Healthy Adult SubjectsCompletedNCT00614991Not applicableResults posted
• Determining the Effects of Observed and Self-Administered Drug Regimens in HIV Infected AdultsCompletedNCT00608569Not applicableResults posted
• Effect of LY450139 on the Long Term Progression of Alzheimer's DiseaseCompletedNCT00594568Phase 3Results posted
• Safety and PK Study of MP-424 to Treat Chronic Hepatitis CCompletedNCT00591214Phase 1Results posted
• Nelfinavir, Radiation Therapy, Cisplatin, and Etoposide in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By SurgeryCompletedNCT00589056Phase 1/2Results posted
• An Exploratory Study of Telaprevir in Treatment-Naive Participants With Chronic Genotype 4 Hepatitis C Virus InfectionCompletedNCT00580801Phase 2Results posted
• Pharmacokinetic Interactions Between Buprenorphine and Kaletra (Lopinavir/Ritonavir)CompletedNCT00571961Not applicableResults posted
• A Study of TMC435350 Administered With or Without Standard of Care Therapy in Participants With Genotype 1 Hepatitis C Virus InfectionCompletedNCT00561353Phase 2Results posted
• A Phase 2a Study to Evaluate Viral Kinetics and Safety of Telaprevir in Participants With Genotype 2 or 3 Hepatitis C InfectionCompletedNCT00561015Phase 2Results posted
• Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT)CompletedNCT00552240Phase 4Results posted
• A Single Ascending Dose Study of Daclatasvir (BMS-790052) in Hepatitis C Virus Infected SubjectsCompletedNCT00546715Phase 1/2Results posted
• Efficacy Study of Substitution of Darunavir/Ritonavir (DRV/r) for Dual-boosted Protease InhibitorsCompletedNCT00543101Phase 4Results posted
• Optimizing Treatment for Treatment-Experienced, HIV-Infected PeopleCompletedNCT00537394Phase 3Results posted
• A Rollover Study for Subjects Participating in the Control Arm of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Whose Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) Levels Did Not Respond to TherapyCompletedNCT00535847Phase 2Results posted
• A Study to Evaluate the Pharmacokinetic Profile (How the Body Absorbs, Distributes, Metabolizes and Eliminates a Drug) of TMC125 Plus Tenofovir/Emtricitabine Once Daily With or Without Darunavir/r Once Daily in Antiretroviral (ARV) Naive HIV-1 Patients (Patients Have Never Received ARV Treatment).CompletedNCT00534352Phase 2Results posted
• Tipranavir/Ritonavir Low Dose Pharmacokinetics in Treatment Naive PatientsCompletedNCT00530920Phase 2Results posted
• A Study of MK-0822 in Postmenopausal Women With Osteoporosis to Assess Fracture Risk (MK-0822-018)TerminatedNCT00529373Phase 3Results posted
• A Study to Compare Effectiveness and Safety of Darunavir/Ritonavir (DRV/Rtv) 800mg/100mg Once Daily Versus DRV/Rtv 600mg/100mg Twice Daily in Early Treatment-Experienced HIV-1 Infected Patients (ODIN)CompletedNCT00524368Phase 3Results posted
• Study the Safety and Effectiveness of MK7009 in Hepatitis C Infected Patients (MK-7009-004)(COMPLETED)CompletedNCT00518622Phase 1Results posted
• Comparison of TPV/r to DRV/r in Triple Class Experienced Patient With Resistance to > 1 PITerminatedNCT00517192Phase 3Results posted
• Deposition of Inhaled Prolastin in Cystic Fibrosis PatientsCompletedNCT00486837Phase 2Results posted
• Pharmacokinetic Interactions Between Buprenorphine and Tipranavir/RitonavirCompletedNCT00486330Not applicableResults posted
• Drug Interaction Study of Lopinavir/Ritonavir and GemfibrozilCompletedNCT00474201Not applicableResults posted
• Enfuvirtide/Current Protease Inhibitor Switch to PREZISTA (Darunavir)/Ritonavir + TMC125 in HIV Patients With Enfuvirtide Side Effects.CompletedNCT00460746Phase 3Results posted
• Treatment Simplification by Darunavir/Ritonavir 800/100 mg Once a Day Versus a Triple Combination Therapy With Darunavir/RitonavirCompletedNCT00458302Phase 3Results posted
• Mechanisms of Lipodystrophy in HIV-Infected PateintsCompletedNCT00457665Phase 4Results posted
• HIV-1 Infection Study of Once a Day Versus Twice a Day Protease Inhibitor in Antiretroviral Treatment Naive AdultsCompletedNCT00450580Phase 3Results posted
• Safety of EVG+RTV Administered With Other Antiretroviral Agents for the Treatment of HIV-1 InfectionCompletedNCT00445146Phase 2Results posted
• Induction/Simplification With Atazanavir + Ritonavir + Abacavir/Lamivudine Fixed-Dose Combination In HIV-1 InfectionCompletedNCT00440947Phase 3Results posted
• SPRING: Safety, Efficacy, Pharmacokinetics of tipRanavir/r IN Race/Gender HIV+ Patients Randomized to TDM or SoCTerminatedNCT00440271Phase 3Results posted
• A Study of Saquinavir/Ritonavir in Liver-Impaired Patients With HIV Infection.CompletedNCT00435929Phase 1Results posted
• A Study of Telaprevir (VX-950), Pegasys and Copegus in Hepatitis C (PROVE3)CompletedNCT00420784Phase 2Results posted
• Safety and Effectiveness of Short-Term Anti-HIV Drug Therapy for Recent HIV-1 InfectionCompletedNCT00414518Not applicableResults posted
• Metabolic Effects of Switching Kaletra to Boosted ReyatazCompletedNCT00413153Not applicableResults posted
• A Study to Examine the Effects of an Experimental Drug on Women With Breast Cancer and Metastatic Bone Disease (MBD)(0822-016)(COMPLETED)CompletedNCT00399802Phase 2Results posted
• Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor)CompletedNCT00396006Phase 4Results posted
• GRACE: A Study to Compare the Effectiveness, Safety and Tolerability of PREZISTA (Darunavir)/Ritonavir by Gender and Race When Administered With Other Antiretroviral Medications in Human Immunodeficiency Virus (HIV) Positive Women and Men.CompletedNCT00381303Phase 3Results posted
• Phase 2 Study of VX-950, Pegasys® With and Without Copegus® in Hepatitis CCompletedNCT00372385Phase 2Results posted
• Study of Lopinavir/Ritonavir Tablets Comparing Once-Daily Versus Twice-Daily Administration When Coadministered With Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Antiretroviral-Experienced Human Immunodeficiency Virus Type 1 Infected SubjectsCompletedNCT00358917Phase 3Results posted
• Safety and Effectiveness of Lopinavir/Ritonavir in Individuals Who Have Failed Prior HIV TherapyCompletedNCT00357552Not applicableResults posted
• Pilot Study of Effect of Kaletra on CD4 Response in HIV Positive (+) Patients With Viral Suppression KIMBO StudyTerminatedNCT00344487Not applicableResults posted
• Antiretroviral Therapy for Advanced HIV Disease in South AfricaCompletedNCT00342355Phase 4Results posted

← Protease Inhibitors overview