Protease Inhibitors: all 1,856 studies that test it

Page 8 of 19. Open to participants first (69), then studies with results posted, then the rest; newest registration first within each.

• Phase IIIb Study to Evaluate the Effectiveness and Safety of Atazanavir/Ritonavir as Single Enhanced Protease Inhibitor Therapy in Human Immunodeficiency Virus (HIV)-Infected Subjects Evidencing Virologic SuppressionCompletedNCT00337467Phase 3Results posted
• Phase 2 Study of VX-950, Pegasys®, and Copegus® in Hepatitis CCompletedNCT00336479Phase 2Results posted
• ALTAIR - Alternative Antiretroviral Strategies : a Comparison of Three Initial RegimensCompletedNCT00335322Phase 4Results posted
• Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral LeukoplakiaCompletedNCT00330382Phase 2Results posted
• Pharmacokinetics of Atazanavir/Ritonavir in HIV-1 Infected Pregnant WomenCompletedNCT00326716Phase 1Results posted
• Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIVCompletedNCT00307151Phase 2Results posted
• The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) DeficiencyCompletedNCT00301366Phase 3Results posted
• A Study To Assess GW433908 (Fosamprenavir) Containing Regimens In HIV-1 Infected SubjectsCompletedNCT00296504Phase 3Results posted
• Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient AdultsCompletedNCT00295061Phase 3Results posted
• BMS-Reyataz Study in Treatment in Naive Subjects to Compare the Efficacy and Safety Between Boosted Reyataz and Kaletra When in Combination With Fixed Dose TruvadaCompletedNCT00272779Phase 3Results posted
• Trizivir Vs. Kaletra and Combivir for the Prevention of Mother-to-Child Transmission of HIVCompletedNCT00270296Phase 2Results posted
• Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE)CompletedNCT00263887Phase 2Results posted
• Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary AngioedemaCompletedNCT00262301Phase 3Results posted
• Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor DeficiencyCompletedNCT00261833Phase 4Results posted
• A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.CompletedNCT00248807Not applicableResults posted
• Nelfinavir Mesylate in Treating Patients With Recurrent, Metastatic, or Unresectable LiposarcomaTerminatedNCT00233948Phase 1/2Results posted
• Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary AngioedemaCompletedNCT00225147Phase 2/3Results posted
• Switch to Atazanavir and Brachial Artery Reactivity (SABAR) StudyCompletedNCT00225017Phase 3Results posted
• Induction-Maintenance With Atazanavir in HIV Naïve Patients (The INDUMA Study)CompletedNCT00207142Phase 4Results posted
• Kaletra Sex/Gender Pharmacokinetics (PK) StudyCompletedNCT00148759Phase 4Results posted
• Rollover Trial Safety and Tolerability of Combination Tipranavir and Ritonavir Use in HIV 1 Infected SubjectsCompletedNCT00146328Phase 2/3Results posted
• Tipranavir/Ritonavir vs. Genotypically Defined Protease Inhibitor/Ritonavir in HIV Patients (RESIST-2)CompletedNCT00144170Phase 3Results posted
• Study of Reyataz in HIV-infected Patients With Lipodystrophy SyndromeCompletedNCT00135356Phase 4Results posted
• Efavirenz or Atazanavir/Ritonavir Given With Emtricitabine/Tenofovir Disoproxil Fumarate or Abacavir/Lamivudine in HIV Infected Treatment-Naive AdultsCompletedNCT00118898Phase 3Results posted
• A Study to Examine the Effects of an Experimental Drug on Postmenopausal Osteoporosis (MK-0822-004)CompletedNCT00112437Phase 2Results posted
• GEMINI Study - A Study of Saquinavir/Ritonavir in Treatment-Naive Patients With HIV-1 InfectionCompletedNCT00105079Phase 3Results posted
• Anti-HIV Drugs for Treating Infants Who Acquired HIV Infection at BirthCompletedNCT00102960Phase 3Results posted
• Comparison of Three Anti-HIV Regimens to Prevent Nevirapine Resistance in Women Who Take Nevirapine During PregnancyCompletedNCT00099632Phase 2Results posted
• Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV TransmissionCompletedNCT00099359Phase 3Results posted
• Nine Month Course of Anti-HIV Medications for People Recently Infected With HIVTerminatedNCT00090779Phase 2Results posted
• 48-Week Study Of GW433908 And Ritonavir Or GW433908 Alone, Twice Daily In Pediatric Patients With HIV InfectionCompletedNCT00089583Phase 2Results posted
• NNRTI vs PI Regimens for HIV Infected Women After They Have Taken Nevirapine to Prevent Mother-To-Child HIV TransmissionCompletedNCT00089505Phase 3Results posted
• Cyclosporine A in Combination With Abacavir Sulfate, Lamivudine, and Zidovudine and Lopinavir/Ritonavir in HIVCompletedNCT00084149Phase 2Results posted
• Prospective Evaluation of Anti-retroviral Combinations for Treatment Naive, HIV Infected Persons in Resource-limited SettingsCompletedNCT00084136Phase 4Results posted
• Preventing Sexual Transmission of HIV With Anti-HIV DrugsCompletedNCT00074581Phase 3Results posted
• Study Of An Investigational Regimen Including FDA Approved HIV Drugs In HIV-Infected Pediatric SubjectsCompletedNCT00071760Phase 2Results posted
• Randomized Evaluation of Strategic Intervention in Multidrug Resistant Patients With Tipranavir (RESIST)CompletedNCT00054717Phase 3Results posted
• A Clinical Study Of An Investigational Regimen Including Marketed HIV Drugs In HIV-1 Pediatric Subjects Ages 2-18 YearsCompletedNCT00040664Phase 2Results posted
• Atazanavir (BMS-232632) in Combination With Ritonavir or Saquinavir, and Lopinavir/Ritonavir, Each With Tenofovir and a Nucleoside in Subjects With HIVCompletedNCT00035932Phase 3Results posted
• Atazanavir Used in Combination With Other Anti-HIV Drugs in HIV-Infected Infants, Children, and AdolescentsCompletedNCT00006604Phase 1/2Results posted
• A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric SarcomasCompletedNCT00001566Phase 2Results posted
• Safety and Efficacy of Racecadotril in Children With Acute Watery DiarrheaCompletedNCT07392931Not applicable
• Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Ethinyl Estradiol/Levonorgestrel (EE/LNG)CompletedNCT07272889Phase 1
• A Study to Learn How the Study Medicine Called Ibuzatrelvir is Taken up Into the Blood in Healthy Chinese AdultsCompletedNCT07235137Phase 1
• To Compare and Evaluate the Oral Bioavailability of Empagliflozin + Linagliptin 10 mg/5 mg Filmcoated Tablets With That of Glyxambi 10 mg/ 5 mg Film-coated Tablets in Healthy, Adult, Human Subjects Under Fasting Conditions.CompletedNCT07039890Phase 1
• A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and AluviaCompletedNCT07002242Phase 1
• Bioequivalence Study to Compare Empagliflozin + Linagliptin 25 mg/5 mg Film-coated Tablets Versus Glyxambi 25 mg/ 5 mg Film-coated TabletsCompletedNCT06932159Phase 1
• A Cardiac Liability Study of Varegacestat in Healthy ParticipantsCompletedNCT06855264Phase 1
• A Phase 1 Mass Balance Study of VaregacestatCompletedNCT06845852Phase 1
• A Varegacestat Hepatic Impairment StudyCompletedNCT06841315Phase 1
• Investigation of Drug-drug Interaction of Ritonavir and Itraconazole on the Pharmacokinetics of SHR-A1811 in Subjects With HER2-expressing Advanced Breast CancerCompletedNCT06710990Phase 1
• Treatment of Hereditary Angioedema Prodrome with Recombinant C1-esterase Inhibitor (Ruconest)CompletedNCT06690047Phase 4
• A Phase 1 Study to Examine the Effects of Itraconazole After Single Dose Administration of Varegacestat (AL102) to Healthy ParticipantsCompletedNCT06677996Phase 1
• A Study to Learn If the Study Medicine Called Carbamazepine Changes How the Body Processes the Other Study Medicine Ibuzatrelvir in Healthy AdultsCompletedNCT06646042Phase 1
• A Study to Learn How Renal Impairment Affects the Pharmacokinetics of PF-07817883.CompletedNCT06586216Phase 1
• Racecadotril Versus Standard Treatment in Decreasing the Duration of Acute Diarrhoea in ChildrenCompletedNCT06529497Phase 1/2
• Evaluation Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of 83-0060 in Healthy VolunteersCompletedNCT06402136Phase 1
• A Study on 2 Different Combination Tablets of Nirmatrelvir Plus Ritonavir to Compare Them With Marketed Paxlovid in Healthy ParticipantsWithdrawnNCT06397144Phase 1
• Efficacy and Safety of Sivelestat in Preventing Postoperative Acute Lung Injury or Acute Respiratory Distress Syndrome After Cardiac SurgeryCompletedNCT06276569Phase 3
• Drug-Drug Interaction Study of Itraconazole With GST-HG171/Ritonavir in Healthy ParticipantsCompletedNCT06087055Phase 1
• Food Effects of GST-HG171 Tablets Combined With Ritonavir in Healthy Chinese ParticipantsActive, not recruitingNCT06084507Phase 1
• Mezigdomide Plus Ixazomib and Dexamethasone for Relapsed and Refractory Multiple MyelomaWithdrawnNCT06050512Phase 1/2
• Study of DAA Treatment for Children and Adolescents With Active HCV Infection in CambodiaActive, not recruitingNCT05992077Not applicable
• A Study to Learn About How Loss of Liver Function Affects the Blood Levels of the Study Medicine Called PF-07817883.CompletedNCT05884554Phase 1
• PAxlovid loNg cOvid-19 pRevention triAl With recruitMent In the Community in NorwayActive, not recruitingNCT05852873Phase 3
• Safety and Pharmacokinetics of SIM0417 Combined With Ritonavir in Healthy Elderly SubjectsStatus unknownNCT05826249Phase 1
• ImPROving Quality of LIFe in the Long COVID PatientCompletedNCT05823896Phase 2
• Efficacy and Safety of Nirmatrelvir/Ritonavir for Treating Omicron Variant of COVID-19CompletedNCT05813600Not applicable
• Hepatic Impairment and Renal Impairment Study of SIM0417 Combined With RitonavirStatus unknownNCT05731804Phase 1
• Effect of Ulinastatin on the Action of NDMRs (Rocuronium / Cisatracurium)CompletedNCT05716256Not applicable
• BXCL701 Phase 1 R/R Acute Myeloid Leukemia or Myelodysplastic SyndromeActive, not recruitingNCT05703542Phase 1
• Sivelestat for Acute Respiratory Distress Syndrome Due to COVID-19Status unknownNCT05697016Not applicable
• A Study of PBI-200 With Ritonavir or Cobicistat in Healthy VolunteersCompletedNCT05692570Phase 1
• Prophylactic Effect of Nirmatrelvir/Ritonavir and Ursodeoxycholic Acid on Reducing Complications After Cardiac SurgeryCompletedNCT05690646Phase 4
• Pharmacokinetic Interaction Between Nitazoxanide and Atazanavir/Ritonavir in Healthy VolunteersCompletedNCT05680792Not applicable
• A Study of Extending Relugolix Dosing Intervals Through Addition of Itraconazole or Ritonavir in Prostate Cancer PatientsTerminatedNCT05679388Phase 1
• Evaluate the Efficacy and Safety of FB2001 for Inhalation in Patients With Mild to Moderate COVID-19Status unknownNCT05675072Phase 2/3
• Neutrophil Elastase Inhibitor in Treatment of ARDS Patients With Mechanical Ventilation Caused by SepsisStatus unknownNCT05672472Not applicable
• A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults with Long COVID.CompletedNCT05668091Phase 2
• Drug-Drug Interaction Study of Itraconazole, Rifampicin and Midazolam With SIM0417/Ritonavir in Healthy ParticipantsCompletedNCT05665647Phase 1
• Study of GST-HG171/Ritonavir Compared With Placebo in Patients With Mild to Moderate COVID-19CompletedNCT05656443Phase 2/3
• Effect of New Oral Treatment for Hepatitis C Virus on Seminal ParametersCompletedNCT05616598Phase 2/3
• Canadian Adaptive Platform Trial of Treatments for COVID-19 in Community SettingsActive, not recruitingNCT05614349Phase 3
• Open Multicentre Study of the Safety and Efficacy Against COVID-19 of Nirmatrelvir/Ritonavir in the Adult PopulationCompletedNCT05601167Phase 3
• A Study of FB2001 for Inhalation in Healthy Chinese AdultsCompletedNCT05583812Phase 1
• A Study to Assess the Safety and Pharmacokinetics of Multiple Ascending Subcutaneous Doses of DS-2325a in Healthy SubjectsCompletedNCT05583669Phase 1
• Bronchiectasis Alpha-1 Augmentation Trial- Modulating Airway Neutrophil FunctionCompletedNCT05582798Phase 4
• Imipenem/Cilastatin/Relebactam Pharmacokinetics, Safety, and Outcomes in Adults and Adolescents With Cystic FibrosisTerminatedNCT05561764Phase 4
• BXCL701 and Pembrolizumab in Patients With Metastatic Pancreatic Ductal AdenocarcinomaActive, not recruitingNCT05558982Phase 2
• A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19WithdrawnNCT05545319Phase 2
• Ulinastatin Improves and Prevents Cardiac Dysfunction Induced by Cardiopulmonary BypassCompletedNCT05534802Not applicable
• PK Subtrial in Adolescent Patients With HAE Type I or II Participating in the KVD900-302 TrialCompletedNCT05511922Phase 3
• A Clinical Study to Evaluate the Efficacy and Safety of SIM0417 Orally Co-Administered With Ritonavir in Symptomatic Adult Participants With Mild to Moderate COVID-19CompletedNCT05506176Phase 2/3
• An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)CompletedNCT05505916Phase 3
• Bioequivalence Study of Nirmatrelvir & Ritonavir From Copaxid 150 +100 mg Tablets (Eva Pharma, Egypt) Versus Paxlovid 150 + 100 mg Film Coated Tablets (Pfizer Europe, Belgium)CompletedNCT05491330Phase 1
• Study to Investigate the Mass Balance and Biotransformation of SIM0417 in Healthy Adult Chinese Male ParticipantsCompletedNCT05475834Phase 1
• Camostat Mesylate for Protein-losing Enteropathy After Fontan OperationCompletedNCT05474664Phase 2
• Efficacy and Safety of SOF/VEL + RBV and SOF/VEL/VOX for 12 Weeks in HCV Subjects With GT3b and Compensated CirrhosisStatus unknownNCT05467826Phase 4
• A Study of RYMPHYSIA for Alpha1-Proteinase Inhibitor (A1PI) Therapy in Adults With A1PI Deficiency and Chronic Obstructive Pulmonary Disease (COPD)-EmphysemaWithdrawnNCT05466747Phase 4
• Glecaprevir/Pibrentasvir for the Treatment of PTSDCompletedNCT05446857Phase 2/3

← Protease Inhibitors overview