Phosphodiesterase 5 Inhibitors: all 685 studies that test it

Page 3 of 7. Open to participants first (38), then studies with results posted, then the rest; newest registration first within each.

• Comparison of Clomiphene Alone Versus Clomiphene Plus Sildenafil for Ovulation in Women With Polycystic Ovary SyndromeCompletedNCT07769476Phase 4
• Comparsion of Effect of PRP,PDE5 Inhibitor in Treatment of Erectile DysfunctionCompletedNCT07761806Phase 2/3
• Effect of Different Dosing Regimens of Tadalafil or Tamsulosin Combined With 5α-Reductase Inhibitors on Urinary and Sexual Outcomes in Benign Prostatic HyperplasiaCompletedNCT07715448Phase 4
• Efficacy and Safety Study of Tunodafil Hydrochloride Tablets in Erectile DysfunctionCompletedNCT07692867Phase 3
• Ultrasonic Enhancement Delivery of Phosphodiesterase Inhibitors Nanoparticles for Diabetic Management of the FootCompletedNCT07690566Not applicable
• Platelet-Rich Plasma With or Without Tadalafil for Erectile DysfunctionCompletedNCT07602608Phase 4
• Efficacy of Transcutaneous Electrical Neural Stimulation and Tadalafil in Men With Erectile Dysfunction: A Randomized, Double-Blind, Bi-centric, Placebo- and Sham-Controlled TrialCompletedNCT07574268Phase 4
• Association Between Diastolic Dysfunction and Erectile Dysfunction and the Effect of Tadalafil and SGLT2 Inhibitors on Them in Men With Metabolic SyndromeCompletedNCT07563647Phase 4
• Sildinafil in Pulmonary Hypertension-Rheumatic Chronic Valvular Disease(RCT)CompletedNCT07462260Phase 2/3
• Double j Stent Related SymptomsCompletedNCT07447518Early Phase 1
• o Tadalafil for Prevention of Docetaxel-Induced Peripheral Neuropathy in Prostate CancerCompletedNCT07333976Phase 2
• Solifenacin Plus Tadalafil vs Solifenacin Alone for Overactive Bladder in FemalesCompletedNCT07312955Not applicable
• Efficacy and Tolerability of Tadalafil Versus Darifenacin in Management of Ureteric Stent-Related LUTSCompletedNCT07206706Phase 1/2
• Safety And Efficacy Of L-Arginine Monotherapy Versus Tadalafil Monotherapy Versus Their Combination In Men With Erectile Dysfunction; A Prospective Randomized StudyCompletedNCT06947265Phase 4
• Vardenafil Vs Sildenafil for the Treatment of Pulmonary Hypertension of the NewbornCompletedNCT06860399Phase 1/2
• Efficacy and Safety of Tadalafil, Tamsulosin, and Their Combinations in Treating Lower Urinary Tract Symptoms in BPH Patients with Prostate Volumes ≤ 40 Ml: a Prospective Comparative StudyCompletedNCT06809205Phase 4
• Actual Use Trial of Tadalafil 5 mgCompletedNCT06805513Phase 3
• The Effect of Combination of Dapagliflozin and Sildenafil in Treatment of Heart Failure Patients With Secondary Pulmonary HypertensionCompletedNCT06778330Not applicable
• Vitamin D Versus Sildenafil Citrate in Fetal Growth RestrictionCompletedNCT06565728Phase 1
• Macitentan and Tadalafil Film-coated Tablets 10 mg/40 mg and 'PrOpsynvi®' Macitentan and Tadalafil Film-coated Tablets 10 mg/40 mgCompletedNCT06553924Phase 1
• Oral Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource SettingsWithdrawnNCT06522854Phase 3
• Administration of Tadalafil in Patients With Benign Prostatic HyperplasiaCompletedNCT06466369Phase 3
• Intrapartum Sildenafil in Laboring MothersWithdrawnNCT06377098Phase 3
• Phosphodiesterase Type 5 Inhibitors in Patients With Group 2 Pulmonary HypertensionCompletedNCT06350773Not applicable
• Management of OAB in Female Patients .CompletedNCT06184334Not applicable
• Cost-effective Treatment of Unexplained InfertilityCompletedNCT06178523Phase 4
• A Study of the Interaction of Tunodafil Hydrochloride Tablets and AlcoholCompletedNCT05976503Phase 1
• Effect of Sildenafil in Individuals With Migraine Pretreated With ErenumabCompletedNCT05889455Not applicable
• Effect of Oral Sildenafil Citrate on Improvement of Endometrial ThicknessCompletedNCT05846906Phase 2/3
• Comparison Between Tamsulosin and Tadalafil in Management of Benign Prostatic Hyperplasia Long Term StudyCompletedNCT05818670Phase 4
• Silodosin, Tadalafil Alone vs. Silodosin Plus Tadalafil as MET for Lower Ureteric StonesCompletedNCT05789732Not applicable
• Using Thermography to Assess the Affects of Sildenafil Cream, 3.6%CompletedNCT05765487Phase 1
• Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained InfertilityCompletedNCT05753098Phase 4
• Tadalafil Effect + Chemotherapy in Resectable Gastric/GEJ CancerActive, not recruitingNCT05709574Phase 2
• A Study Investigating the Safety, Tolerability, Drug Levels and Drug Effect of BMS-986278 in Healthy Adult Participants (Part 1) and Japanese Participants (Part 2)CompletedNCT05684289Phase 1
• Hypersensitivity to Phosphodiesterase 5 Inhibition in Post-Traumatic HeadacheStatus unknownNCT05669885Not applicable
• Clinical Study to Evaluate the Possible Efficacy and Safety of L- Carnitine and Sildenafil in Children Having Beta Thalassemia With Increased Tricuspid Regurgitant Jet VelocityStatus unknownNCT05584956Phase 3
• Intrapartum Sildenafil Citrate to Prevent Non Reassuring Foetal Status Among Parturients Delivering at TermStatus unknownNCT05558176Phase 4
• Sildenafil Added Effect in Dapoxetine Non-responding Mono-symptomatic Premature Ejaculation (PE)Status unknownNCT05556083Phase 2
• The Efficacy of Tamsulosin and Tadalafil Compared to Placebo in the Treatment and Prevention of Urinary Disorders After Transperineal Prostate BiopsyStatus unknownNCT05537272Phase 4
• Efficacy of Tadalafil/Solifenacin VS Tamsulosin/Solifenacin Combination Therapy for BPH/OABStatus unknownNCT05494567Phase 4
• Investigational and Comparative Study in the Management of Diabetic NephropathyCompletedNCT05487755Phase 3
• Comparing The Effect of Tadalafil 5 mg/Day to Sildenafil 25 mg/Day on Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in Erectile Dysfunction Patients; and Comparison of Clinical ResponseStatus unknownNCT05466695Early Phase 1
• Serum YKL-40 Level and Platelets Indices Among Patients With Diabetic Erectile DysfunctionCompletedNCT05446493Phase 4
• Comparison Between Efficacy of Topical Sildenafil 2% and Topical Minoxidil 5% in Treatment of Androgenic AlopeciaStatus unknownNCT05369481Not applicable
• Finding Solutions to Thrive After Birth Asphyxia in AfricaCompletedNCT05275725Phase 1
• Efficiency of Tadalafil for Management of Female Sexual DysfunctionStatus unknownNCT05266651Phase 2/3
• (Phosphodiesterase 5 Inhibitors & α-blockers): Single Versus Combined Therapy in Benign Prostatic HyperplasiaStatus unknownNCT05236634Not applicable
• A Study of Fixed Dose Combination of Macitentan/Tadalafil (10 mg/20 mg) Compared to the Reference Free Combination of Macitentan and Tadalafil in Healthy Adult ParticipantsCompletedNCT05236231Phase 1
• Tadalafil as Adjuvant Therapy for DMDActive, not recruitingNCT05195775Phase 2/3
• Combined On-demand Sildenafil Citrate and Tramadol Hydrochloride for Treatment of Premature EjaculationStatus unknownNCT05183334Phase 4
• Improving Cerebral Blood Flow and Cognition in Patients with Cerebral Small Vessel Disease. the ETLAS-2 TrialActive, not recruitingNCT05173896Phase 2
• Impact of Tadalafil 5 mg on Post-micturition Dribble in Young-age Men With no/Mild Lower Urinary Tract SymptomsStatus unknownNCT05146674Not applicable
• A Trial for Prevention of Recurrent Ischemic Priapism in Men With Sickle Cell Disease: A Pilot StudyCompletedNCT05142254Phase 2
• Endocan Level in Patients With Erectile Dysfunction and Relationship With Tadalafil TreatmentStatus unknownNCT05109377Not applicable
• Effects of Single Dose Tadalafil on Urethral and Anal Closure FunctionCompletedNCT05095077Phase 1
• The Phosphodiesterase Inhibitor Tadalafil as an Adjunct to Antidepressants in Major Depressive Disorder PatientsWithdrawnNCT05030623Phase 1/2
• Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of SildenafilCompletedNCT04994860Phase 1
• The Impact of Sildenafil on the Pulmonary Circulation in Healthy Trained and Untrained HumansCompletedNCT04985929Phase 2
• Multi-Center Study to Evaluate the Efficacy and Safety of Sildenafil Cream (3.6%) in Premenopausal Patients With Female Sexual Arousal DisorderStatus unknownNCT04948151Phase 2
• Endovenous Sildenafil Early Management in Newborns Pulmonary HypertensionWithdrawnNCT04912726Not applicable
• Sildenafil for Liver Fibrosis in Adolescents and Adults After Fontan OperationStatus unknownNCT04908657Phase 4
• Bioequivalence Study of Two Formulations of Sildenafil Tablet 100 mg in Healthy Male Volunteers Under Fasting ConditionsStatus unknownNCT04882826Phase 1
• Tadalafil to Overcome Immunosuppression During Chemoradiotherapy for IDH-wildtype Grade III-IV AstrocytomaCompletedNCT04757662Phase 1
• Effect of Sildenafil Citrate on Mid Luteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy LossCompletedNCT04718233Phase 2
• Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord InjuriesActive, not recruitingNCT04565925Phase 2
• A Study of Macitentan/Tadalafil Combination Administered a Fixed-dose Combination Formulation Compared to the Reference Free Combination of Macitentan and TadalafilCompletedNCT04540744Phase 1
• Copd Exacerbation and Pulmonary Hypertension TrialCompletedNCT04538976Phase 4
• Low Dose Tadalafil for Treatment of Female OAB Syndrome: Short Term Follow up.CompletedNCT04500860Phase 1
• Sildenafil in COVID-19CompletedNCT04489446Phase 1/2
• Study of Pharmacological Treatment in Women With Female Sexual Interest/Arousal Disorder (FSIAD).Status unknownNCT04433559Phase 3
• Efficacy and Safety of Milrinone Versus Sildenafil in the Treatment of Neonates With Persistent Pulmonary HypertensionCompletedNCT04391478Phase 1
• Daily Avanafil for Erectile DysfunctionCompletedNCT04374994Phase 4
• The Phosphodiesterase 5 Inhibitor Sildenafil as an Adjunct to Antidepressants in Major Depressive Disorder PatientsWithdrawnNCT04344678Not applicable
• Sildenafil Citrate and Intrapartum Fetal DistressCompletedNCT04325243Phase 4
• A Pilot Study of Sildenafil in COVID-19Status unknownNCT04304313Phase 3
• Endometrial Effects of Sildenafil in Frozen-Thawed Cycles in Women With Thin EndometriumStatus unknownNCT04283435Phase 1
• Sildenafil in Acute Pulmonary EmbolismCompletedNCT04283240Early Phase 1
• A Study of Macitentan and Tadalafil as a Fixed Dose Combination and the Free Combination in Healthy Adult ParticipantsCompletedNCT04235270Phase 1
• A 2-part Study to Investigate the Effect of Macitentan in Healthy Male ParticipantsCompletedNCT04211272Phase 1
• The Prevention of Progression to Pancreatic Cancer Trial (The 3P-C Trial)Active, not recruitingNCT04207944Phase 2
• Evaluation of Drug Interactions of Saxagliptin With Sildenafil in Healthy VolunteersStatus unknownNCT04170790Not applicable
• Sildenafil to Repair Brain Injury Secondary to Birth AsphyxiaCompletedNCT04169191Phase 1
• Pharmacotherapy and Psychotherapy in the Treatment of Erectile DysfunctionCompletedNCT04126252Not applicable
• PDE5i Use in Renal Transplant RecipientsWithdrawnNCT04122105Not applicable
• A Comparative Pharmacokinetic and Pharmacodynamic Study of Sildenafil in Adult Smokers and Non SmokersCompletedNCT04100759Phase 1/2
• Marrow Infiltrating Lymphocytes - Non-Small Cell Lung Cancer (MILs™ - NSCLC) Alone or in Combination With Nivolumab With or Without Tadalafil in Locally Advanced and Unresectable or Metastatic NSCLCTerminatedNCT04069936Phase 2
• Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in MilitaryTerminatedNCT04058132Phase 2
• Phosphodiesterase Inhibitors in Glaucoma Study (PhiGS)SuspendedNCT04052269Phase 3
• Mono vs. Dual Therapy for Pediatric Pulmonary Arterial HypertensionCompletedNCT04039464Phase 3
• Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart DiseaseWithdrawnNCT03997097Phase 3
• Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?CompletedNCT03945643Early Phase 1
• Effect of Tadalafil Administration on Vasodilatation Mediated by Flow in Patients With Obesity Grade I-IIStatus unknownNCT03905018Phase 3
• Oxford Haemodynamic Adaptation to Reduce Pulsatility TrialCompletedNCT03855332Phase 2
• Effect of Vaginal Sildenafil Citrate on Endometrial Preparation and Outcome in Frozen Thawed Embryo Transfer CyclesStatus unknownNCT03854175Not applicable
• Daily Oral L-arginine Plus Tadalafil in Diabetic Patients With Erectile DysfunctionCompletedNCT03834610Not applicable
• Sildenafil Citrate in Early Unexplained Recurrent Pregnancy LossCompletedNCT03766594Phase 1
• Sildenafil in Hemodialysis Patients With Pulmonary HypertensionStatus unknownNCT03763045Phase 2/3
• Esomeprazole With Sildenafil Citrate in Women With Early-onset PreeclampsiaStatus unknownNCT03724838Not applicable
• Endurance Performance at AltitudeCompletedNCT03710369Not applicable

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