Phosphodiesterase 5 Inhibitors: all 685 studies that test it

Page 1 of 7. Open to participants first (38), then studies with results posted, then the rest; newest registration first within each.

• Effects of Tadalafil on Cognition and Cerebral Hemodynamics in Elderly Patients With Mild Cognitive ImpairmentNot yet recruitingNCT07882901Phase 2
• The Effect of Additive On-Demand Sildenafil vs. Dextrose Candy on Maximum Exercise Capacity in Pulmonary Arterial HypertensionRecruitingNCT07824674Phase 2/3
• Tamsulosin With or Without Tadalafil for Trial Without Catheter After Acute Urinary Retention Due to Benign Prostatic HyperplasiaRecruitingNCT07654413Phase 4
• L-Citrulline and Tadalafil for Mild to Moderate Erectile DysfunctionRecruitingNCT07642505Phase 4
• Multimodal Prehabilitation and Rehabilitation for Men Undergoing Robot-Assisted Radical ProstatectomyRecruitingNCT07576335Phase 2
• Effect of Tadalafil on Endometrial Thickness and Frozen Embryo Transfer OutcomesRecruitingNCT07499804Phase 4
• Tadalafil 5 mg on Storage Lower Urinary Tract Symptoms After Anatomical Endoscopic Enucleation of the ProstateNot yet recruitingNCT07466030Phase 1
• Randomized Controlled Trial Comparing Low Dose Tadalafil Versus Solifenacin For Management of Overactive Bladder in Women: Multicenter Egyptian National StudyRecruitingNCT07416968Phase 4
• Daily Tadalafil 5 mg Combined With On-Demand Sildenafil 100 mg for Treatment of Erectile Dysfunction in PDE-5I Non Responder PatientsRecruitingNCT07391579Phase 4
• Combination Therapy of Tadalafil 2.5mg Plus Sildenafil 25mg Versus Tadalafil 5 mg Monotherapy for Treatment of Erectile Dysfunction: A Randomized, Placebo-Controlled Double-Blinded Cross-Over StudyNot yet recruitingNCT07177326Phase 3
• Comparison Between Treatments of OligohydramniosRecruitingNCT07135037Phase 2
• Asciminib With or Without Sildenafil for Brain TumorsNot yet recruitingNCT07039760Early Phase 1
• Comparison of Sequential to Initial Combination Therapy in PAHRecruitingNCT06968962Not applicable
• Sildenafil Plus Hypothermia to Treat Neonatal EncephalopathyNot yet recruitingNCT06810284Phase 2
• Sildenafil to Prevent and Reduce Cancer Related Cognitive ImpairmentNot yet recruitingNCT06800092Phase 2/3
• Study to Compare the Effects of Viagra® Vs Hezkue® in Healthy Fasted Male Participants.Not yet recruitingNCT06782659Phase 1
• Evaluation of Efficacy of Botulinum Toxin A Plus Oral Tadalafil 5 mg in Diabetic Men With Erectile DysfunctionRecruitingNCT06583590Phase 2/3
• Genetic Factors of Erectile Dysfunction Degree and Response to Tadalafil Treatment in Patients With DiabetesRecruitingNCT06520839Phase 3
• Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device SupportRecruitingNCT06510322Early Phase 1
• Medications for Lower Urinary Tract Symptoms Secondary to Benign Prostatic HyperplasiaRecruitingNCT06491108Phase 3
• IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver DiseaseRecruitingNCT06324396Phase 1
• Vasodilator and Exercise Study for DMD (VASO-REx)RecruitingNCT06290713Phase 2
• Preoperative Sildenafil Administration for HepatectomyRecruitingNCT06237751Not applicable
• Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal CancerRecruitingNCT06123156Phase 3
• Treatment of Neonatal Encephalopathy With Oral Sildenafil Suspension to Repair Brain Injury Secondary to Birth AsphyxiaRecruitingNCT06098833Phase 2
• Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer OutcomesNot yet recruitingNCT05971667Phase 2/3
• The Effect of Sildenafil Citrate on Frozen Embryo Transfer CyclesRecruitingNCT05951413Phase 2/3
• Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PHRecruitingNCT05937854Phase 2
• Fontan Udenafil Exercise Longitudinal Assessment Trial - 2RecruitingNCT05918211Phase 3
• Tadalafil for Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary DiseaseRecruitingNCT05844462Phase 3
• Efficacy and Safety of Focused Shockwave Therapy Plus Tadalafil vs Tadalafil Alone in Patient With Erectile DysfunctionRecruitingNCT05823506Not applicable
• Study of Tadalafil vs. Placebo for Improving Hemodynamics and End-Organ Dysfunction in Fontan PhysiologyRecruitingNCT05206955Phase 3
• A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)RecruitingNCT05201144Phase 2
• A Study Providing Treatment Access in Participants With Pulmonary Hypertension Completing a Parent Study and Having no Other OptionRecruitingNCT05179876Phase 3
• Oral Sildenafil for Exercise Capacity, Dyspnea and Cardiopulmonary Function in COPDRecruitingNCT05061368Phase 2
• The Effects of Mirabegron and Tadalafil on Glucose Tolerance in PrediabeticsRecruitingNCT05051436Phase 4
• Sildenafil for Early Pulmonary Vascular Disease in SclerodermaRecruitingNCT04797286Phase 2
• A Single Dose Randomized Five-Way Crossover Pharmacokinetics (PK) Study of Tadalafil Semi-Chewable (Gummy) Formulations in Healthy VolunteersNot yet recruitingNCT04762082Phase 1
• Study of CRS-207, Pembrolizumab, Ipilimumab, and Tadalafil in Metastatic Pancreatic CancerCompletedNCT05014776Phase 2Results posted
• Clinical Investigation Using MED3000 Gel or Tadalafil Tablets in the Treatment of Erectile DysfunctionCompletedNCT04984993Phase 3Results posted
• Effect of PDE5 Inhibition on Adipose Metabolism in HumansCompletedNCT04684589Phase 2Results posted
• Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary DysplasiaCompletedNCT04447989Phase 2Results posted
• Sildenafil for Treatment of Choroidal IschemiaCompletedNCT04356716Phase 2Results posted
• Sildenafil Exercise: Role of PDE5 InhibitionCompletedNCT04039087Phase 2/3Results posted
• Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck CancerCompletedNCT03993353Phase 2Results posted
• Nivolumab (Anti-PD1), Tadalafil and Oral Vancomycin in People With Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer From Colorectal or Pancreatic CancersTerminatedNCT03785210Phase 2Results posted
• Hypoxic Pulmonary Vasoconstriction Pilot StudyCompletedNCT03733470Phase 4Results posted
• Improving Right Ventricular Function in Young Adults Born PretermCompletedNCT03696758Phase 2Results posted
• Sildenafil for Swimming-Induced Pulmonary Edema (SIPE) PreventionCompletedNCT03686813Phase 2Results posted
• Sildenafil Treatment for Mild TBITerminatedNCT03598140Phase 2Results posted
• Evaluation of Fontan-associated Hepatic Stiffness and the Efficacy of Udenafil in Reducing Liver StiffnessCompletedNCT03430583Phase 3Results posted
• Sildenafil To Prevent ClotCompletedNCT03199612Early Phase 1Results posted
• Role of Sildenafil for Fontan Associated Liver Disease (SiFALD) StudyCompletedNCT03154476Phase 3Results posted
• Safety of Sildenafil in Premature InfantsCompletedNCT03142568Phase 2Results posted
• A Extension Study of Udenafil in AdolescentsCompletedNCT03013751Phase 3Results posted
• Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Intermediate or High Probability of Group 3 Pulmonary HypertensionCompletedNCT02951429Phase 2Results posted
• Does Sildenafil Improve Endothelial Dysfunction in Rheumatoid Arthritis?TerminatedNCT02908490Phase 2Results posted
• PDE5 Inhibition for Obesity-Related Cardiometabolic DysfunctionCompletedNCT02819440Phase 2Results posted
• Fontan Udenafil Exercise Longitudinal Assessment TrialCompletedNCT02741115Phase 3Results posted
• Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin EndometriumCompletedNCT02710981Not applicableResults posted
• Evaluation and Treatment of Pulmonary Vascular Disease in Moderate to Severe CFCompletedNCT02626182Phase 1/2Results posted
• Effect of Tadalafil on Insulin Secretion and Insulin Sensitivity in Obese Men.CompletedNCT02595684Phase 4Results posted
• A Study of Tadalafil (LY450190) in Participants With Lower Urinary Tract Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia LUTS (BPH-LUTS).CompletedNCT02431754Phase 4Results posted
• Phosphodiesterase Type 5 Inhibition to Improve Endothelial Function and Vascular Remodeling in Chronic Kidney Disease and End Stage Renal Disease Patients Requiring New Arteriovenous FistulaCompletedNCT02414204Not applicableResults posted
• Sildenafil for the Treatment of Lymphatic MalformationsCompletedNCT02335242Phase 2Results posted
• Sildenafil in Heart Failure With Reactive Pulmonary HypertensionTerminatedNCT02304705Phase 4Results posted
• A Study of LY2623091 in Healthy ParticipantsCompletedNCT02300259Phase 1Results posted
• A Study of Tadalafil (LY450190) in Chinese Men With Erectile DysfunctionCompletedNCT02224846Phase 4Results posted
• Pharmacokinetic/Pharmacodynamic Study of Udenafil in AdolescentsCompletedNCT02201342Phase 1/2Results posted
• A Study of LY2623091 in Participants With High Blood PressureCompletedNCT02194465Phase 2Results posted
• Sildenafil (Viagra) for the Treatment of Dyskinesias in Parkinson's DiseaseTerminatedNCT02162979Phase 2Results posted
• Effect of Prolonged PDE-5 Inhibition on Insulin Signaling in Skeletal Muscle.CompletedNCT02129725Phase 4Results posted
• Effects of Oral Sildenafil on Mortality in Adults With PAHTerminatedNCT02060487Phase 4Results posted
• Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Diastolic Cardiomyopathy (Aim3)CompletedNCT02058095Phase 1/2Results posted
• Blood Flow and Vascular Function in Cystic FibrosisCompletedNCT02057458Phase 2Results posted
• Safety Study Looking at the Effects of Stendra on VisionCompletedNCT02033200Phase 4Results posted
• Improving Erectile Function and Quality of Life After Prostate Cancer TreatmentTerminatedNCT01996852Not applicableResults posted
• Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2)CompletedNCT01970176Phase 1/2Results posted
• Effect of Sildenafil on Diffusion Capacity in Patients With PH and Parenchymal Lung DiseaseCompletedNCT01948518Not applicableResults posted
• A Study of Tadalafil in Men With Benign Prostatic Hyperplasia (BPH) and Erectile Dysfunction (ED)CompletedNCT01937871Phase 3Results posted
• Phosphodiesterase Type 5 Inhibition With Tadalafil Changes Outcomes in Heart FailureTerminatedNCT01910389Phase 3Results posted
• A Study of Tadalafil for Duchenne Muscular DystrophyTerminatedNCT01865084Phase 3Results posted
• Tadalafil for Pulmonary Hypertension Due to Chronic Lung DiseaseCompletedNCT01862536Phase 2Results posted
• Surgery Plus Sulindac or Surgery Alone for Advanced Colorectal CancerTerminatedNCT01856322Phase 2Results posted
• Effects of Sildenafil on Choroidal Thickness in AMDTerminatedNCT01830790Phase 2Results posted
• A Study of Tadalafil in Pediatric Participants With Pulmonary Arterial Hypertension (PAH)CompletedNCT01824290Phase 3Results posted
• Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade GliomaCompletedNCT01817751Phase 2Results posted
• Study Evaluating the Effects of Avanafil on Semen ParametersCompletedNCT01768676Phase 4Results posted
• NSAID Effects on Clinical and Imaging Breast BiomarkersCompletedNCT01761877Phase 2Results posted
• Sildenafil in HFpEF (Heart Failure With Preserved Ejection Fraction) and PHCompletedNCT01726049Phase 3Results posted
• A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The NewbornCompletedNCT01720524Phase 3Results posted
• Research Evaluating a PDE5 Inhibitor for Erectile DysfunctionCompletedNCT01698684Phase 4Results posted
• A Phase II Trial of Tadalafil in Patients With Squamous Cell Carcinoma of the Upper Aero Digestive TractCompletedNCT01697800Phase 2Results posted
• The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual FatigueCompletedNCT01661595Not applicableResults posted
• Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial HypertensionCompletedNCT01642407Phase 4Results posted
• Evaluation of Drug-drug Interaction Between LCZ696 and Sildenafil in Subjects With Mild to Moderate HypertensionCompletedNCT01601470Phase 2Results posted
• Tadalafil and Nesiritide as Therapy in Pre-clinical Heart FailureCompletedNCT01544998Phase 1/2Results posted
• The Boceprevir and Sildenafil Pharmacokinetics StudyCompletedNCT01499498Phase 1Results posted
• A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial HypertensionCompletedNCT01484431Phase 1/2Results posted
• Trial of Eflornithine Plus Sulindac in Patients With Familial Adenomatous Polyposis (FAP)CompletedNCT01483144Phase 3Results posted

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