Drug
Opevesostat clinical trials
Also written MK-5684 and ODM-208.
- studies test it
- 11
- open now
- 3
- in phase 3
- 2
- first study started
- 2023
Keep track of what changes. Save the opevesostat studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Studies by the year they started
11 studies that test it; most in 2024 (4)
| Year | Studies |
|---|---|
| 2023 | 3 |
| 2024 | 4 |
| 2025 | 3 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 8
- Phase 2
- 1
- Phase 3
- 2
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 11 · Other 0
Often tested with
Tested in the same studies.
Itraconazole (1) · Carbamazepine (1) · Fulvestrant (1) · Exemestane (1) · Megestrol Acetate (1) · Megestrol (1) · Medroxyprogesterone Acetate (1) · Medroxyprogesterone (1)
Studies
Open first, then newest update. How each study uses opevesostat is read from its arms, and is right about nine times in ten.
Testing it · 11
- A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06136650Written as Opevesostat
- Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06136624Written as Opevesostat
- A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)RecruitingPhase 2Merck Sharp & Dohme LLCNCT06979596Written as Opevesostat
- A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-017)CompletedPhase 1Merck Sharp & Dohme LLCNCT07548606Written as Opevesostat
- A Study of Opevesostat (MK-568)4 in Japanese Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-005)CompletedPhase 1Merck Sharp & Dohme LLCNCT06104449Written as Opevesostat
- A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (MK-5684-001)CompletedPhase 1Merck Sharp & Dohme LLCNCT06136598Written as Opevesostat
- A Study to Evaluate Opevesostat (MK-5684) in Male Participants With Moderate Hepatic Impairment (MK-5684-009)CompletedPhase 1Merck Sharp & Dohme LLCNCT06860243Written as Opevesostat
- A Study to Evaluate the Effect of MK-5684 in Male Participants With Severe Renal Impairment (RI) and With End-stage Renal Disease (ESRD) (MK-5684-010)CompletedPhase 1Merck Sharp & Dohme LLCNCT06814132Written as MK-5684
- A Drug-Drug Interaction Study of Carbamazepine and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-012)CompletedPhase 1Merck Sharp & Dohme LLCNCT06633419Written as Opevesostat
- A Study of the Absorption, Distribution, Metabolism, and Elimination of Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-008)CompletedPhase 1Merck Sharp & Dohme LLCNCT06566989Written as [¹⁴C]Opevesostat
- A Drug-Drug Interaction Study of Diltiazem and MK-5684 in Healthy Adult Male Participants (MK-5684-011)CompletedPhase 1Merck Sharp & Dohme LLCNCT06554639Written as MK-5684
Given in every arm · 3 — opevesostat is usual care beside what is tested
- Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT06353386Written as Opevesostat
- A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT06863272Written as Opevesostat
- Safety and Pharmacokinetics of ODM-208 in Patients With Metastatic Castration-resistant Prostate CancerActive, not recruitingPhase 1/2Orion Corporation, Orion PharmaNCT03436485Written as ODM-208
Codes
What other systems call opevesostat · ClinicalTrials.gg INT014372
- UNII (FDA) 1Z7MAV4KQCOPEVESOSTATOne source FDA
- NCI Thesaurus C156744OpevesostatOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| UNII (FDA) | 1Z7MAV4KQC | OPEVESOSTAT | One source FDA |
| NCI Thesaurus | C156744 | Opevesostat | One source FDA |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.