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WithdrawnNCT00505583Updated Nov 29, 2019

Study Evaluating Oral MOA-728 in Subjects on Methadone Therapy

A Phase 1 interventional study of MOA-728 in Methadone-maintenance Subjects, sponsored by Bausch Health Americas, Inc.. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-11-29.

Sponsored by Bausch Health Americas, Inc. · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Enrollment
0
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

To evaluate the effects of single oral doses of MOA-728 compared to a positive control in subjects on methadone therapy.

02

Conditions studied

  • Methadone-maintenance Subjects
03

In context

Lead sponsor

Bausch Health Americas, Inc. is the lead sponsor of 209 studies on the registry; 9 are open to participants now.

Of its 23 completed or terminated interventional studies of FDA-regulated products, 16 (70%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  1. Healthy men or women, aged 18 to 65 years.
  2. History of methadone treatment for at least 1 month, at a dose >=30 and \<=140 mg/day.

Exclusion criteria

Exclusion:

  1. History or active presence of clinically important medical disease.
  2. Allergy to opioids.
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double
Enrollment
0 participants (actual)

Interventions

  • DrugMOA-728
06

What researchers measure

Primary outcomes

  1. To characterize the pharmacodynamics of single oral doses of MOA-728 compared to a positive control of MOA-728 administered intravenously in subjects on stable methadone maintenance.

07

Study locations

1 site
  • Gainesville, Florida 32608, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 29, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00505583
Lead sponsor
Bausch Health Americas, Inc.
First posted
Jul 23, 2007
Start date
Jul 2007
Primary completion
Dec 2007 (estimated)
Completion
Dec 2007 (estimated)
Last update
Nov 29, 2019

Study contacts

Jeff Cohn
study director · Bausch Health Americas, Inc.
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Nov 2019. You cannot join it, but the record below documents what was studied.

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