Mitotane clinical trials
Also written Lysodren.
How each study uses Mitotane is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Mitotane studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- 8 Jul 1970 · LYSODREN · NDA 016885 (FDA, Drugs@FDA)
- European Union
- 28 Apr 2004 · Lysodren · EMEA/H/C/000521 (EMA)
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
6 studies that test it; most in 2008 (2)
| Year | Studies |
|---|---|
| 2008 | 2 |
| 2013 | 1 |
| 2018 | 1 |
| 2022 | 1 |
| 2025 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 0 · Other 6
University Health Network, Toronto (1) · M.D. Anderson Cancer Center (1) · West China Hospital (1) · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (1) · National Cancer Institute (NCI) (1) · University of Turin, Italy (1)
Often tested with
Tested in the same studies.
Apatinib (1) · Etoposide (1) · Doxorubicin (1) · Cisplatin (1) · Megestrol Acetate (1) · Megestrol (1) · Cixutumumab (1)
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 2
Studies that test Mitotane.
- Dec 2026Phase II Study of PD-1 Inhibitor Combined With Apatinib and Mitotane in the Treatment of Advanced Adrenal Cortical CarcinomaPhase 2 · West China Hospital
- Jun 2027Evaluation of the Efficacy of Addition of Progesterone to Standard Chemotherapy in Adrenocortical Carcinoma (ACC)Phase 2 · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Studies
Open first, then newest update. How each study uses Mitotane is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 6
- Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Patients With Stage I-III Adrenocortical Cancer With High Risk of RecurrenceRecruitingPhase 3M.D. Anderson Cancer CenterNCT03583710Written as Mitotane
- Phase II Study of PD-1 Inhibitor Combined With Apatinib and Mitotane in the Treatment of Advanced Adrenal Cortical CarcinomaRecruitingPhase 2West China HospitalNCT06831175Written as mitotane
- Evaluation of the Efficacy of Addition of Progesterone to Standard Chemotherapy in Adrenocortical Carcinoma (ACC)RecruitingPhase 2Azienda Socio Sanitaria Territoriale degli Spedali Civili di BresciaNCT05913427Written as Etoposide, doxorubicin, cisplatin and Mitotane plus Megestrol Acetate 160 MG
- Efficacy of Adjuvant Mitotane Treatment (ADIUVO)Status unknownPhase 3University of Turin, ItalyNCT00777244Written as MITOTANE
- A Safety and Feasibility Study of Mitotane in Prostate CancerCompletedPhase 1University Health Network, TorontoNCT02057237Written as Mitotane
- IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That Cannot Be Removed by SurgeryTerminatedPhase 2National Cancer Institute (NCI)NCT00778817Written as mitotane
Given beside what is tested · 3 — Mitotane is usual care or a partner of the new treatment
- A Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Mitotane in Patients With Advanced Adrenocortical CarcinomaTerminatedPhase 2M.D. Anderson Cancer CenterNCT05634577Written as Mitotane
- Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical TumorCompletedPhase 3Children's Oncology GroupNCT00304070Written as Mitotane
- Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT)CompletedPhase 3Collaborative Group for Adrenocortical Carcinoma TreatmentNCT00094497Written as Mitotane
Codes
What other systems call Mitotane · ClinicalTrials.gg INT007847
- MeSH (NLM) D008939MitotaneConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 78E4J5IB5JMITOTANEConfirmed FDA, NLM, Wikidata
- RxNorm 7004Confirmed FDA, Wikidata
- Wikidata Q417465(RS)-mitotaneConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C664MitotaneOne source FDA
- DrugBank DB00648One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008939 | Mitotane | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 78E4J5IB5J | MITOTANE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 7004 | — | Confirmed FDA, Wikidata |
| Wikidata | Q417465 | (RS)-mitotane | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C664 | Mitotane | One source FDA |
| DrugBank | DB00648 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.