Mineralocorticoid Receptor Antagonists: all 312 studies that test it

Page 1 of 4. Open to participants first (46), then studies with results posted, then the rest; newest registration first within each.

• Reducing Arterial Inflammation Using Eplerenone and Statins in HIVNot yet recruitingNCT07892664Phase 2/3
• Cardiac Improvement by Eplerenone Among Patients Under Cyclosporine or Tacrolimus for Kidney Transplantation.Not yet recruitingNCT07828223Phase 3
• Eplerenone and IOP in Healthy AdultsNot yet recruitingNCT07795762Phase 1
• Early Aldo Blockade in Subclinical PANot yet recruitingNCT07727252Phase 2/3
• Efficacy and Safety of Spironolactone in Pediatric Hemodialysis Patients With Anemia.Not yet recruitingNCT07715318Phase 2
• SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive TherapyNot yet recruitingNCT07687160Phase 4
• Regression in Left Ventricular Hypertrophy and Fibrosis in Aortic StenosisNot yet recruitingNCT07539259Phase 2
• HEART: Pilot Randomized Controlled TrialRecruitingNCT07483177Phase 1/2
• Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face StudyNot yet recruitingNCT07473895Phase 2
• A Phase 1b/2a Study to Evaluate the Safety, Pharmacokinetics, and Objective Response of STAR-001 (LP-184) in Combination With Spironolactone in Supratentorial Glioblastoma at First ProgressionNot yet recruitingNCT07431216Phase 1/2
• Spironolactone and XPB-1 Integrity in the TFIIH ComplexEnrolling by invitationNCT07415811Not applicable
• A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced MalignanciesRecruitingNCT07340190Phase 1
• A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in PreeclampsiaNot yet recruitingNCT07293728Phase 4
• Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of PregnancyRecruitingNCT07238400Phase 2
• Spironolactone to Improve Pregnancy-Associated Hypertension TrajectoriesRecruitingNCT07041281Phase 2
• Swedish Cardiac And Renal Failure Study-1RecruitingNCT07029503Phase 2
• The Role of Skin Sodium Accumulation in Chronic Kidney DiseaseRecruitingNCT07020104Not applicable
• Vascular Effects of High-Salt After PreeclampsiaRecruitingNCT06749418Early Phase 1
• Drospirenone Only Pills and Cervical Mucus Changes: A Pre- and Post-Bariatric Surgery StudyRecruitingNCT06345586Not applicable
• Pharmacokinetics of Drospirenone Only Pills: A Pre- and Post-Bariatric Surgery StudyRecruitingNCT06345560Phase 1/2
• Optimal Medical Treatment of Difficult-to-treat HypertensionRecruitingNCT06275763Phase 4
• The Predictive Role of Urinary Proteomics in Blood Pressure Response of Obese Hypertensive Treated With Irbesartan or Eplerenone.RecruitingNCT06208072Not applicable
• SPironolactONe for the Maintenance of Sinus Rhythm in Patients With Atrial FibrillationNot yet recruitingNCT06204640Phase 3
• Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart DiseaseNot yet recruitingNCT06168994Phase 4
• Determination of Drug Levels for Pharmacotherapy of Heart FailureNot yet recruitingNCT06035978Phase 4
• A Phase IV, Two-part, Open-label Study Assessing the Pharmacokinetics, Safety and Pharmacodynamics of Spironolactone Oral Suspension in Pediatric PatientsNot yet recruitingNCT06021860Phase 4
• Effect of Spironolactone in the Prevention of Anthracycline-induced Cardiotoxicity (SPIROTOX)Not yet recruitingNCT06005259Phase 4
• Estetrol/Drospirenone to Reduce the Average Size of EndometriomasRecruitingNCT05837624Phase 4
• Spironolactone in Alcohol Use Disorder (SAUD)RecruitingNCT05807139Phase 1
• Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical TreatmentRecruitingNCT05797558Not applicable
• Quadruple Immunotherapy for NeuroblastomaRecruitingNCT05754684Phase 2
• Effect of MRA on Cardiovascular Disease in Patients With Hypertension and HyperaldosteronemiaEnrolling by invitationNCT05688579Phase 4
• Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in HypertensionRecruitingNCT05593055Phase 4
• A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS)RecruitingNCT05394142Phase 2
• Effect of Antifibrotic Therapy on Regression of Myocardial Fibrosis After Transcatheter Aortic Valve Implantation (TAVI) in Aortic Stenosis Patients With High Fibrotic BurdenRecruitingNCT05230901Phase 3
• Stratified Medicine of Eplerenone in Acute Myocardial Infarction or Injury and no Obstructive Coronary Arteries.RecruitingNCT05198791Phase 2
• Evaluation of Spironolactone Efficacy in Patient with Rheumatoid Arthritis (RA)RecruitingNCT05092984Phase 3
• Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical StudyRecruitingNCT05030545Phase 4
• Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?RecruitingNCT04723862Early Phase 1
• The Effect of Eplerenone on the Evolution of Vasculopathy in Renal Transplant Patients.RecruitingNCT04450953Phase 3
• Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?RecruitingNCT04075149Early Phase 1
• A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart FailureEnrolling by invitationNCT03984591Phase 4
• Blockade of the Renin-angiotensin-aldosterone System in Patients With ARVDRecruitingNCT03593317Phase 2
• Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection FractionRecruitingNCT02901184Phase 3
• Spironolactone for Pulmonary Arterial HypertensionRecruitingNCT01712620Phase 2
• Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen ExcessRecruitingNCT01422759Not applicable
• Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium AssessmentCompletedNCT05411991Phase 4Results posted
• Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in ObesityCompletedNCT04519164Phase 4Results posted
• Antiarrhythmic Effects of Spironolactone in Patients With ICDsCompletedNCT04495712Phase 4Results posted
• Evaluating Drug Interactions Between Doravirine With Estradiol and Spironolactone in Healthy Transgender WomenCompletedNCT04283656Phase 1Results posted
• Metabolic and Neuro-Endocrine Effect of Treating PCOS in AdolescentsCompletedNCT03981861Phase 2/3Results posted
• Pressure Assessment to Improve Outcomes After TAVR: a RegistryCompletedNCT03923530Early Phase 1Results posted
• Drug-drug Interaction (DDI) Study of Spironolactone (Perpetrator) and Digoxin (Substrate Drug)CompletedNCT03909529Phase 1Results posted
• Spironolactone Versus Prednisolone in DMDTerminatedNCT03777319Phase 1Results posted
• Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Add-OnTerminatedNCT03597035Phase 4Results posted
• Spironolactone Therapy In Young Women With NASHCompletedNCT03576755Phase 1/2Results posted
• Spironolactone After Liver TransplantCompletedNCT02883400Phase 4Results posted
• E4 FREEDOM (Female Response Concerning Efficacy and Safety of Estetrol/Drospirenone as Oral Contraceptive in a Multicentric Study) - United States/Canada StudyCompletedNCT02817841Phase 3Results posted
• E4 FREEDOM (Female Response Concerning Efficacy and Safety of Estetrol/Drospirenone as Oral Contraceptive in a Multicentric Study) - EU/Russia StudyCompletedNCT02817828Phase 3Results posted
• Effects of Eplerenone on Cardiovascular Disease in HIV (MIRACLE HIV Study)CompletedNCT02740179Not applicableResults posted
• Cardiometabolic Effects of Eplerenone in HIV InfectionTerminatedNCT02629094Phase 2Results posted
• Mineralocorticoid Receptor Antagonists (MRA) in Heart Failure (HF) and Loop Diuretic ResistanceCompletedNCT02585843Phase 2/3Results posted
• Evaluating Alternative Medical Therapies in Primary HyperparathyroidismCompletedNCT02525796Phase 2/3Results posted
• Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney DiseaseCompletedNCT02497300Phase 2Results posted
• Therapeutic Potential for Aldosterone Inhibition in Duchenne Muscular DystrophyCompletedNCT02354352Phase 3Results posted
• Safety and Cardiovascular Efficacy of Spironolactone in Dialysis-Dependent ESRD TrialCompletedNCT02285920Phase 2Results posted
• Safety, Efficacy, Tolerability and Pharmacokinetics of LF111 (Drospirenone 4.0 mg) During 13 CyclesCompletedNCT02269241Phase 3Results posted
• The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension StudyTerminatedNCT02253394Phase 4Results posted
• Tissue Sodium in Pre-hypertensive PatientsCompletedNCT02236520Phase 2Results posted
• Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart FailureCompletedNCT02235077Phase 2Results posted
• Biomarker Guided Therapies in Stage A/B Heart FailureCompletedNCT02230891Phase 2Results posted
• Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis TrialCompletedNCT02169089Phase 4Results posted
• Endogenous Renin-Angiotensin-Aldosterone System and Glucose MetabolismCompletedNCT02034435Phase 4Results posted
• The Role of Aldosterone on Augmented Exercise Pressor Reflex in HypertensionCompletedNCT01996449Phase 2Results posted
• Eplerenone for the Treatment of Central Serous ChorioretinopathyCompletedNCT01990677Not applicableResults posted
• Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart FailureCompletedNCT01973335Phase 4Results posted
• The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart DiseaseTerminatedNCT01971593Phase 4Results posted
• Etiology of Sleep Apnea-related Hyperaldosteronism - BP TreatmentCompletedNCT01897727Not applicableResults posted
• Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and CetuximabCompletedNCT01867294Phase 2Results posted
• Mineralocorticoid Antagonism and Endothelial Dysfunction in Autosomal Dominant Polycystic Kidney Disease (ADPKD)CompletedNCT01853553Phase 3Results posted
• Eplerenone for Central Serous ChorioretinopathyCompletedNCT01822561Phase 2Results posted
• Effect of Eplerenone on Postprandial Inflammatory Response in Healthy AdultsCompletedNCT01786551Not applicableResults posted
• Evaluation of CLP With and Without Spironolactone in Heart Failure Patients With Chronic Kidney DiseaseCompletedNCT01598740Phase 1Results posted
• Eplerenone for Subclinical Cardiomyopathy in Duchenne Muscular DystrophyCompletedNCT01521546Not applicableResults posted
• Mineralocorticoid Receptor and Obesity Induced Cardiovascular ComplicationsCompletedNCT01406015Not applicableResults posted
• Hypoglycemia and the Mineralocorticoid ReceptorCompletedNCT01394627Not applicableResults posted
• Patiromer in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN)CompletedNCT01371747Phase 2Results posted
• Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained MenCompletedNCT01294319Phase 2Results posted
• Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial InfarctionCompletedNCT01176968Phase 4Results posted
• Clinical Study Of Eplerenone In Japanese Patients With Chronic Heart FailureCompletedNCT01115855Phase 3Results posted
• Effect of Estradiol+Drospirenone Versus Estradiol+MPA on Endothelial FunctionCompletedNCT01109979Phase 4Results posted
• Aldosterone and the Metabolic SyndromeCompletedNCT01103245Phase 1Results posted
• Spironolactone in Adult Congenital Heart DiseaseCompletedNCT01069510Phase 2Results posted
• The Effect of Spironolactone on Blood Pressure in Type-2 Diabetics With Resistant HypertensionCompletedNCT01062763Phase 3Results posted
• Clinical and Therapeutic Implications of Fibrosis in Hypertrophic CardiomyopathyCompletedNCT00879060Phase 4Results posted
• Role of Mineralocorticoid Receptor in Diabetic Cardiovascular DiseaseCompletedNCT00865124Not applicableResults posted
• Study to Evaluate Cycle Control With Norgestimate/Ethinyl Estradiol and Drospirenone/Ethinyl Estradiol in Healthy Sexually Active FemalesCompletedNCT00745901Phase 4Results posted
• A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HSTerminatedNCT00722800Phase 2Results posted
• Safety and Efficacy Of Drospirenone and Ethinyl Estradiol vs Placebo in the Treatment of Truncal AcneCompletedNCT00722761Phase 3Results posted
• The Oral Contraceptive Pill for Premenstrual Worsening of DepressionCompletedNCT00633360Not applicableResults posted

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