Linaclotide: all 43 studies that test it

Page 1 of 1. Open to participants first (3), then studies with results posted, then the rest; newest registration first within each.

• MRI Parameters as Biomarkers in Cystic Fibrosis (FEMPTO)Not yet recruitingNCT07780344Not applicable
• Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic FibrosisRecruitingNCT07569419Early Phase 1
• Clinical Study on the Application of Lactulose Combined with Linaclotide in Bowel Preparation for ColonoscopyEnrolling by invitationNCT06748638Phase 4
• A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treated With LinaclotideCompletedNCT05760313Phase 2Results posted
• A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional ConstipationCompletedNCT05652205Phase 3Results posted
• Linaclotide Safety and Efficacy in 2 to 5-Year-Old Participants With Functional ConstipationCompletedNCT04110145Phase 2Results posted
• Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC)CompletedNCT04026113Phase 3Results posted
• A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)CompletedNCT03573908Phase 3Results posted
• A Study of the Effect of Linaclotide on Abdominal Girth in Participants With Irritable Bowel Syndrome With Constipation (IBS-C)TerminatedNCT02837783Phase 4Results posted
• An Open-Label, Long-term Study to Assess the Immunogenicity of LINZESS® (Linaclotide) Administered Orally to Adult Participants With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic ConstipationCompletedNCT02590432Phase 4Results posted
• A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With ConstipationTerminatedNCT02559817Phase 2Results posted
• A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 6-17 Years Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation (FC)CompletedNCT02559570Phase 2Results posted
• Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)CompletedNCT02559206Phase 2Results posted
• Trial of Linaclotide in Patients With Chronic Idiopathic ConstipationCompletedNCT02291679Phase 3Results posted
• Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer PainCompletedNCT02270983Phase 2Results posted
• Efficacy of Linaclotide to Senna for CICTerminatedNCT02239510Not applicableResults posted
• A Phase 3, International, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy and Safety Trial of Linaclotide Administered Orally for 12 Weeks to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)CompletedNCT01880424Phase 3Results posted
• Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal BloatingCompletedNCT01642914Phase 3Results posted
• Trial of Linaclotide Administered to Patients With Irritable Bowel Syndrome With ConstipationCompletedNCT00948818Phase 3Results posted
• An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With ConstipationCompletedNCT00765999Phase 3Results posted
• Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic ConstipationCompletedNCT00765882Phase 3Results posted
• An Open-label, Long-term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With ConstipationCompletedNCT00730171Phase 3Results posted
• Trial of Linaclotide in Patients With Chronic ConstipationCompletedNCT00730015Phase 3Results posted
• Randomized, Double-blind, Dose-range-finding, Phase 2 Study of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)CompletedNCT00460811Phase 2Results posted
• Dose-range-finding, Phase 2 Trial of Oral Linaclotide Acetate Administered to Patients With Chronic ConstipationCompletedNCT00402337Phase 2Results posted
• Effect to Linaclotide on Colonic MotilityCompletedNCT06989268Phase 4
• Effect and Safety of Polyethylene Glycol Combined With Linaclotide on Colon Cleansing for Patients With Chronic ConstipationStatus unknownNCT05137145Not applicable
• Efficacy of Linaclotide in Patients With Overlapping Functional Gastrointestinal DisordersStatus unknownNCT05134584Phase 4
• GCC Agonist Signal in the Small IntestineCompletedNCT05107219Phase 1
• Evaluation of Clinical Equivalence Between Two Linaclotide Products in the Treatment of Chronic Idiopathic ConstipationStatus unknownNCT04804267Phase 3
• Linaclotide in Treating Patients With Stages 0-3 Colorectal CancerActive, not recruitingNCT03796884Phase 2
• A Study of Oral Dosing of ASP0456 in Patients With Chronic ConstipationCompletedNCT02809105Phase 3
• Single-dose Linaclotide for Capsule Endoscopy PreparationCompletedNCT02465385Phase 4
• A Study to Evaluate Dose Responses of Efficacy and Safety of ASP0456 in Patient With Chronic ConstipationCompletedNCT02425722Phase 2
• Phase III Study to Evaluate the Efficacy and Safety of ASP0456 in Patients With Constipation Predominant Irritable Bowel SyndromeCompletedNCT02316899Phase 3
• A Lactation Study in Women Who Are Breastfeeding or Pumping and Are Receiving Linaclotide TherapeuticallyCompletedNCT02220348Phase 1
• Investigation of Linaclotide's Effect on the Bi-directional Brain and Gut Axis in IBS-C PatientsCompletedNCT02078323Not applicable
• Linaclotide Acetate in Preventing Colorectal Cancer in Healthy VolunteersCompletedNCT01950403Phase 1
• A Study to Evaluate the Effect of ASP0456 in Patients With Constipation Predominant Irritable Bowel SyndromeCompletedNCT01714843Phase 2
• A Study to Evaluate Safety of Multiple Dose of ASP0456 in Healthy SubjectsCompletedNCT01427387Phase 1
• A Safety and Pharmacokinetics Study of ASP0456 in Healthy SubjectsCompletedNCT01279915Phase 1
• Phase 2 Study of MD-1100 Acetate Administered for 14 Days to Patients Meeting Criteria for Chronic ConstipationCompletedNCT00306748Phase 2
• Phase 2 Study of MD-1100 Acetate on Gastrointestinal Transit in Patients With C-IBSCompletedNCT00258193Phase 2

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