A Phase 3 interventional study of Stannous fluoride toothpaste and Colgate Cavity Protection Toothpaste in Plaque and Gingivitis, sponsored by Colgate Palmolive. Completed at 1 site in Thailand. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-19.
Sponsored by Colgate Palmolive · Phase 3, Interventional, and Treatment
Qualified subjects will be enrolled and randomly assigned to either of the two study groups based on their initial Plaque and Gingivitis scores. During the first visit, subjects will undergo three key procedures: 1) evaluation for baseline plaque and gingivitis, 2) brushing with the assigned regimen products for two minutes, and 3) assessment for post-brushing plaque only. Subjects will be provided with clear instructions for regimen product usage and will be expected to adhere to these instructions. Follow-up evaluations for plaque and gingivitis will be conducted at one week, six weeks, and three months after initiation of regimen product use. Throughout the study period, continuous monitoring for adverse events will be carried out for all subjects.
89 studies on the registry are indexed under Plaque, Amyloid; 37 are open to participants now.
This study's enrollment of 95 is below the median of 110 across 63 interventional studies indexed under Plaque, Amyloid.
Browse Plaque, Amyloid studies →Colgate Palmolive is the lead sponsor of 114 studies on the registry; 12 are open to participants now.
Of its 33 completed or terminated interventional studies of FDA-regulated products, 2 (6%) have results posted.
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Exclusion Criteria:
brush for 2 min, 2x/day, morning and night
Drug: Stannous fluoride toothpaste
brush for 2 min, 2x/day, morning and night
Drug: Colgate Cavity Protection Toothpaste
brush 2 min morning \& night daily
brush 2 min morning \& night daily
Loe and Silness Gingival Index.
A Loe-Silness Gingival Index score from 0 to 3 will be assigned by the examining dentist to all scoreable surfaces of the maxillary and mandibular teeth using a dental light and dental mirror. A whole mouth mean score for each subject will be determined by adding the values given by the examining dentist to each scoreable surface and dividing that number by the total number of surfaces scored.
Time frame: baseline, one week, six weeks and three months
Quigley and Hein Plaque Index
A Quigley-Hein Plaque Index score of 0 to 5 will be assigned to all scoreable disclosed surfaces of the maxillary and mandibular teeth using a dental light and dental mirror. A whole mouth score for each subject will be determined by adding the values given by the dental examiner to each scoreable surface and dividing that number by the total number of surfaces scored.
Time frame: baseline, one week, six weeks and three months
Plan to share: No
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This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Colgate Palmolive