Diphosphonates clinical trials
A group of medicines. Zoledronic Acid (275 studies), Alendronate (91 studies), Risedronic Acid (72 studies) and others are counted on their own pages; this page counts the studies that name Diphosphonates itself.
How each study uses Diphosphonates is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Diphosphonates studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- Not in FDA's approval records
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
Medicines filed under Diphosphonates
As reviewed, so not every one. Each counts its studies on its own page, not here.
Studies by the year they started
6 studies that test it; most in 2011 (2)
| Year | Studies |
|---|---|
| 2008 | 1 |
| 2011 | 2 |
| 2016 | 1 |
| 2023 | 1 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 0 · Other 6
Children's Cancer Hospital Egypt 57357 (1) · Queen's University (1) · Tuen Mun Hospital (1) · Second Affiliated Hospital, School of Medicine, Zhejiang University (1) · Wake Forest University Health Sciences (1) · Parc de Salut Mar (1)
Often tested with
Tested in the same studies.
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Tested against it · 1 phase 3 study under way
Diphosphonates is the comparator. A study of two new drugs counts under both.
- 1Romosozumab · Amgen · next primary completion May 2027
Studies
Open first, then newest update. How each study uses Diphosphonates is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 6
- Bone, Exercise, Alendronate, and Caloric RestrictionRecruitingPhase 4Wake Forest University Health SciencesNCT05764733Written as Bisphosphonate
- Prospective, Randomized, Multicenter Clinical Trial of Bisphosphonates Combined With Vancomycin for the Treatment of Cierny-Mader Type I and III OsteomyelitisNot yet recruitingPhase 3Second Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT07435051Written as Bisphosphonates Combined with Vancomycin
- Breast Cancer Women on Aromatase Inhibitors TreatmentStatus unknownPhase 4Parc de Salut MarNCT03811509Written as bisphosphonate
- Zometa Study in Pediatric Acute Lymphoblastic LeukemiaCompletedPhase 3Children's Cancer Hospital Egypt 57357NCT01656512Written as zolendronic acid
- Queen's University Investigation of Calcification in Chronic Kidney DiseaseCompletedPhase 3Queen's UniversityNCT00687661Written as Bisphosphonate
- Denosumab in Current Users of Bisphosphonates for Glucocorticoid-induced OsteoporosisCompletedPhase 4Tuen Mun HospitalNCT01465568Written as bisphosphonates
Given beside what is tested · 4 — Diphosphonates is usual care or a partner of the new treatment
- Zanzalintinib for Metastatic Clear Cell Renal Cell Carcinoma With Bone MetastasesRecruitingPhase 2Kelly Fitzgerald, MDNCT07043608Written as Investigator Choice of Bone Strengthening Agents (BSA)
- Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis ImperfectaActive, not recruitingPhase 3Ultragenyx Pharmaceutical IncNCT05768854Written as Bisphosphonate
- Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression FracturesWithdrawnPhase 4University of California, DavisNCT03651804Written as Bisphosphonates
- First Autologous Transplant on Minimal Residual Disease Markers in Previously Untreated Myeloma Undergoing Initial Treatment With VelcadeCompletedPhase 2Vanderbilt-Ingram Cancer CenterNCT01215344Written as Bisphosphonates
As the comparator · 2 — what is tested is compared with Diphosphonates
- Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis ImperfectaActive, not recruitingPhase 3AmgenNCT05972551Written as Bisphosphonate
- Denosumab (AMG 162) in Bisphosphonate Naive Metastatic Breast CancerCompletedPhase 2AmgenNCT00091832Written as IV Bisphosphonates
Codes
What other systems call Diphosphonates · ClinicalTrials.gg INT007378
- MeSH (NLM) D004164DiphosphonatesOne source ClinicalTrials.gov
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D004164 | Diphosphonates | One source ClinicalTrials.gov |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.