Alkylating agents: all 3,295 studies that test it

Page 17 of 33. Open to participants first (456), then studies with results posted, then the rest; newest registration first within each.

• Neoadjuvant Chemo-endocrine Therapy and Immunotherapy for Pre-menopausal Luminal B Breast Cancer PatientsCompletedNCT04659551Phase 2
• Low Dose Continuous Cyclophosphamide vs Standard Doxorubicin in Advanced Sarcoma Elderly PatientsTerminatedNCT04656262Phase 3
• CAR-T Cells for HIV InfectionActive, not recruitingNCT04648046Phase 1/2
• CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)Active, not recruitingNCT04637763Phase 1
• CAR-T for Children With Relapsed and Refractory Acute Lymphoblastic LeukemiaStatus unknownNCT04626765Early Phase 1
• CAR-T Cells in Treating Patients With Relapsed or Refractory Multiple MyelomaStatus unknownNCT04626752Early Phase 1
• CAR-T Cells in Treating Patients With Relapsed or Refractory NHLStatus unknownNCT04626739Early Phase 1
• Adult B-ALL Treated by CART Cell Bridging Allogeneic Hematopoietic Stem Cell TransplantationStatus unknownNCT04626726Early Phase 1
• Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's MacroglobulinemiaActive, not recruitingNCT04624906Phase 2
• NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDSActive, not recruitingNCT04623944Phase 1
• Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS TuberculosisStatus unknownNCT04620772Phase 2/3
• Comparison of BTD and BCD Based Regimens in the Treatment of AL AmyloidosisStatus unknownNCT04612582Phase 4
• TEMOkids Study : A Phase I Pediatric Study for KIMOZO, Oral Suspension of TemozolomideCompletedNCT04610736Phase 1
• Nab-PTX, Ifosfamide and Cisplatin in the Treatment of Pediatric Extracranial Germ Cell Tumor.Status unknownNCT04581265Phase 2
• Mesothelin-targeted CAR T-cell Therapy in Patients With MesotheliomaActive, not recruitingNCT04577326Phase 1
• Multiparametric MR-Guided High Dose Adaptive Radiotherapy With Concurrent Temozolomide in Patients With Newly Diagnosed GlioblastomaActive, not recruitingNCT04574856Phase 2
• A Study to Evaluate the Efficacy and Safety of Bendamustine Hydrochloride InjectionCompletedNCT04569838Phase 2
• Phase I Trial of DNA-PK Inhibitor (PEPOSERTIB ) in Combination With Radiation and Adjuvant Temozolomide in Newly Diagnosed MGMT Unmethylated and Recurrent GlioblastomaActive, not recruitingNCT04555577Phase 1
• Liposomal Mitoxantrone Hydrochloride Injection,Cyclophosphamide, Vincristine and Prednisone in the Treatment of PTCLTerminatedNCT04548700Phase 1
• HSRT and IMRT Chemoradiotherapy for Newly Diagnosed GBMStatus unknownNCT04547621Phase 1/2
• A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From Young Non-first-degree and Older First-degree Donors in Hematological MalignanciesActive, not recruitingNCT04547049Phase 3
• Temodar Plus Tyrosine Kinase Inhibitors for Progressive CNS DiseaseCompletedNCT04541407Phase 1
• Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, GD2-CAR PERSIST TrialSuspendedNCT04539366Phase 1
• Regorafenib in Combination With Metronomic Chemotherapies, and Low-dose Aspirin in Metastatic Colorectal CancerCompletedNCT04534218Phase 2
• Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in AdultsActive, not recruitingNCT04530565Phase 3
• Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain CancerWithdrawnNCT04521946Phase 1
• Sequential Regimen of Bendamustine Followed by Obinutuzumab (GA101), Zanubrutinib (BGB-3111) and Venetoclax (ABT-199) in Patients With Relapsed/Refractory CLLActive, not recruitingNCT04515238Phase 2
• Ibrutinib With Methotrexate and Temozolomide for Patients With Newly Diagnosed Primary CNS LymphomaStatus unknownNCT04514393Phase 2
• Conjunctival Vascularity Changes Usnig OCTA After TrabeculectomyStatus unknownNCT04493073Early Phase 1
• Targeted Drug Combined With CHOP in the Treatment of Newly Diagnosed Peripheral T-cell LymphomaActive, not recruitingNCT04480099Phase 2
• Polatuzumab Vedotin and Combination Chemotherapy for the Treatment of Previously Untreated LymphomaActive, not recruitingNCT04479267Phase 2
• TIP (Paclitaxel + Ifosfamide + Cisplatin) Combined With Nimotuzumab & Triprilimab as Neoadjuvant Treatment in Locally Advanced Penile CancerCompletedNCT04475016Phase 2
• Study of Tumor Treating Fields With Hypofractionated Chemoradiotherapy in Newly Diagnosed GlioblastomaCompletedNCT04474353Phase 1
• Haplo Peripheral Blood Sct In GVHD PreventionCompletedNCT04473911Phase 1
• Bioequivalence Study Between Temozolomide Oral Suspension (Ped-TMZ) and Temodal® CapsulesCompletedNCT04467346Phase 1
• Temozolomide, Cisplatin, and Nivolumab in People With Colorectal CancerCompletedNCT04457284Phase 2
• A Prospective International Multicenter Clinical Trial for Eyes With Relapsed RetinoblastomaTerminatedNCT04455139Phase 2
• VR-CAP in the First-line Treatment for Patients With Marginal Zone LymphomaCompletedNCT04433156Phase 2
• Comparison between2 Drugs in Lupus NephritisCompletedNCT04424602Phase 4
• A Study of Fluzoparib (SHR-3162) and Temozolomide With or Without SHR-1316 in Treating Patients With Replapsed Small Cell Lung CancerCompletedNCT04400188Phase 1/2
• Low Dose Treosulfan Based Conditioning Regimen in HSCT for Nijmegen Breakage SyndromeStatus unknownNCT04400045Phase 2
• Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed GlioblastomaTerminatedNCT04397679Phase 1
• TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe Systemic SclerosisActive, not recruitingNCT04380831Early Phase 1
• Low-doses Melphalan Inhalation in Patients With COVID-19 (CoronavIrus Disease 2019) PneumoniaStatus unknownNCT04380376Phase 2
• Reduced Intensity Transplantation for Severe Sickle Cell DiseaseActive, not recruitingNCT04362293Phase 2
• Intra-arterial Chemotherapy for RetinoblastomaCompletedNCT04342572Phase 1
• NordicTrip, a Translational Study of Preoperative Chemotherapy in TNBCActive, not recruitingNCT04335669Phase 3
• Parsaclisib Plus the Standard Drug Therapy in Patients With Newly Diagnosed, High Risk Diffuse Large B-cell LymphomaActive, not recruitingNCT04323956Phase 1
• "Cocktail" Therapy for Hepatitis B Related Hepatocellular CarcinomaStatus unknownNCT04317248Phase 2
• Neoadjuvant Chemotherapy With Pyrotinib, Epirubicin and Cyclophosphamide Followed by Taxanes and Trastuzumab for HER-2+ Breast CancerActive, not recruitingNCT04290793Phase 2/3
• CD34+ Enriched Transplants From HLA-Compatible Patients With Hematologic MalignanciesWithdrawnNCT04282174Phase 2
• Anticancer Therapeutic Vaccination Using Telomerase-derived Universal Cancer Peptides in GlioblastomaCompletedNCT04280848Phase 2
• Inhalations of Ultra-low Doses of Melphalan for the Treatment of Non-cystic Fibrosis BronchiectasisStatus unknownNCT04278040Phase 2
• Nivolumab in Combination With Temozolomide and Radiotherapy in Children and Adolescents With Newly Diagnosed High-grade GliomaCompletedNCT04267146Phase 1/2
• Anti-CD7 U-CAR-T Cell Therapy for T/NK Cell Hematologic MalignanciesStatus unknownNCT04264078Early Phase 1
• Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute LeukemiaActive, not recruitingNCT04262843Phase 2
• The CAPER Trial: A Phase Ib Clinical Trial of Cyclophosphamide And PEmbrolizumab in Metastatic Renal Cell CarcinomaStatus unknownNCT04262427Phase 1/2
• The Effect of Chemoradiotherapy in Patients With Refractory Pituitary AdenomasStatus unknownNCT04244708Phase 2/3
• Study of Pomalidomide, Oral Dexamethasone and Very Low-dose Cyclophosphamide in Patients With Refractory Multiple Myeloma Who Have Received Lenalidomide and BortezomibTerminatedNCT04243109Phase 2
• Polatuzumab Vedotin and Combination Chemotherapy With or Without Glofitamab for the Treatment of Untreated Aggressive Large B-cell LymphomaActive, not recruitingNCT04231877Phase 1/2
• Preconditioning of Tumor, Tumor Microenvironment and the Immune System to ImmunotherapyCompletedNCT04225390Phase 2
• Phase II Study of Neoadjuvant Weekly Paclitaxel and Carboplatin Followed by Dose Dense Epirubicin and Cyclophosphamide in Stage II and III Triple Negative Breast CancerCompletedNCT04224922Phase 2
• Repurposing Chlorpromazine in the Treatment of GlioblastomaStatus unknownNCT04224441Phase 2
• Phase II Study of Durvalumab ,Doxorubicin, and Ifosfamide in Pulmonary Sarcomatoid CarcinomaCompletedNCT04224337Phase 2
• Vorinostat and Combination Chemotherapy Before Donor Stem Cell Transplantation for the Treatment of Relapsed Aggressive B-cell or T-cell Non-Hodgkin LymphomaWithdrawnNCT04220008Phase 2
• REACH: Study to Determine the Aetiology of Chlormethine Gel Induced-skin Drug Reaction in Early Stage Mycosis Fungoides Cutaneous T Cell Lymphoma (MF-CTCL)TerminatedNCT04218825Phase 2
• A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCTActive, not recruitingNCT04217278Phase 2/3
• A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, INSPIRE TrialActive, not recruitingNCT04216290Phase 2
• CD19 Chimeric Antigen Receptor (CAR) T Cells for Adults With Recurrent or Refractory B Cell MalignanciesActive, not recruitingNCT04214886Phase 1
• DCV in the Treatment of Recurrence and Refractory Childhood Solid TumorsStatus unknownNCT04213612Phase 1
• NK Cells Infusions With Irinotecan, Temozolomide, and DinutuximabActive, not recruitingNCT04211675Phase 1/2
• ATG Plus PTCy vs ATG for CGVHD ProphylaxisActive, not recruitingNCT04202835Phase 2
• Chemoembolization for Lung TumorsCompletedNCT04200417Phase 1
• A Study of Maprotiline in Combination With Tamoxifen and Temozolomide for Recurrent GlioblastomaWithdrawnNCT04200066Phase 1
• Open-Label, Phase 1 Study to Evaluate Duration of Severe Neutropenia After Same-Day Dosing of Eflapegrastim in Patients With Breast-CancerCompletedNCT04187898Phase 1
• Nab-paclitaxel Compared With Docetaxel Followed by Anthracyclines and Cyclophosphamide in the Neoadjuvant Breast CancerStatus unknownNCT04182568Phase 4
• Study of alloCART-19 Cell Therapy in Pediatric Patients With Relapsed/Refractory B-Cell Acute Lymphoblastic LeukemiaActive, not recruitingNCT04173988Early Phase 1
• Daratumumab Combined With Bortezomib, Cyclophosphamide and Dexamethasone for the Treatment of Multiple Myeloma Patients Presenting With Extramedullary DiseaseActive, not recruitingNCT04166565Phase 2
• Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE StudyActive, not recruitingNCT04166318Phase 2
• Autologous Transplant Targeted Against Crohn'sWithdrawnNCT04154735Phase 2
• A Risk Stratified Sequential Treatment With Rituximab, Brentuximab Vedotin and Bendamustine (RBvB)WithdrawnNCT04138875Phase 2
• Apatinib Combined With Chemotherapy in the Treatment of Soft Tissue SarcomaStatus unknownNCT04126811Phase 2
• Temozolomide for Second-Line Treatment of Neuroendocrine CarcinomasCompletedNCT04122911Phase 2
• Thalidomide, Cyclophosphamide and Dexamethasone for Recurrent/Refractory Adult Langerhans Cell HistiocytosisStatus unknownNCT04120519Phase 2
• Non-Viral TCR Gene TherapyWithdrawnNCT04102436Phase 2
• Giving Chemotherapy for a Shortened Amount of Time Before a Stem Cell TransplantationActive, not recruitingNCT04098393Phase 1
• T Cells co- Expressing a Second Generation Glypican 3-specific Chimeric Antigen Receptor With Cytokines Interleukin-21 and 15 as Immunotherapy for Patients With Liver Cancer (TEGAR)WithdrawnNCT04093648Phase 1
• Evaluate the Safety and Effectiveness of Intranasal Administration of Temozolomide in Patients With GlioblastomaCompletedNCT04091503Phase 1
• A Phase 2 Trial for Men With Metastatic Prostatic AdenocarcinomaCompletedNCT04090775Phase 2
• Phase 2 Trial of Neoadjuvant Weekly Carboplatin Plus Paclitaxel in Triple Negative Breast CancerActive, not recruitingNCT04083963Phase 2
• Isatuximab, Bendamustine, and Prednisone in Refractory Multiple MyelomaTerminatedNCT04083898Phase 1
• Nab-paclitaxel Based Regimens VS Paclitaxel Based Regimens in Neoadjuvant Treatment for TNBCWithdrawnNCT04067102Not applicable
• Famitinib Plus Camrelizumab & Famitinib Alone & Famitinib Plus Ifosfamide in Advanced OsteosarcomaWithdrawnNCT04044378Phase 1/2
• COX Inhibition and Biomarkers During Neoadjuvant Chemoendocrine Therapy for ER+, HER2- Stage I-III Breast CancerWithdrawnNCT04038489Phase 2
• CRISPR (HPK1) Edited CD19-specific CAR-T Cells (XYF19 CAR-T Cells) for CD19+ Leukemia or Lymphoma.Status unknownNCT04037566Phase 1
• Efficacy of Topical Mitomycin C for Complex Benign Esophageal Anastomotic StricturesWithdrawnNCT04037072Phase 2
• Short Course Chemo-Radiation Therapy for Patients With Newly Diagnosed GlioblastomaActive, not recruitingNCT04019262Phase 1/2
• Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell TransplantationActive, not recruitingNCT04018937Phase 2
• Apatinib Mesylate Combined With Doxorubicin and Ifosfamide in Advanced Soft-tissue SarcomaStatus unknownNCT04012827Phase 2
• a Clinical Trial of Efficacy and Safety of the Holistic Treatment of Young High-risk Multiple Myeloma PatientsStatus unknownNCT04008888Not applicable

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