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Waldenstrom Macroglobulinemia clinical trials

The registry lists 524 studies for Waldenstrom Macroglobulinemia across more than 10 countries. 62 are recruiting or about to start. 114 of them are mainly about Waldenstrom Macroglobulinemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

ClinicalTrials.gov finds 527 studies for Waldenstrom Macroglobulinemia. How that becomes 524 here

This page counts the studies the registry files under Waldenstrom Macroglobulinemia, and those it files under no condition that list Waldenstrom Macroglobulinemiathemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 527Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −3List Waldenstrom Macroglobulinemia as a condition, but the registry did not file them under itMost often written as “Waldenstrom Macroglobulinemia With Nodal Disease” (1), “Lymphoplasmacytic Lymphoma (With or Without Waldenstrom Macroglobulinemia)” (1), and “Smoldering Waldenstrom Macroglobulinemia(WM)” (1). The registry filed them under other conditions only, most often Lymphoma, B-Cell, Marginal Zone (2) and Lymphoma, Follicular (2).
  3. −1Match it another way1 in a keyword.
  4. 523Counted here and found by its search2 of them list Waldenstrom Macroglobulinemia in their own words; the registry filed them under no condition.
  5. +1
    Counted here, but its search does not find them
  6. 524The count on this page

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Status

Completed
308
Terminated
76
Recruiting
48
Active, not recruiting
30
Withdrawn
24
Status unknown
21

Phase

Phase 2
255
Phase 1
211
Phase 3
31
Phase 4
8
Early Phase 1
4

Where

United States
419
France
41
Italy
36
Germany
31
United Kingdom
31
Canada
28

Who runs them

National Cancer Institute (NCI) (51) · Fred Hutchinson Cancer Center (36) · Dana-Farber Cancer Institute (26) · Mayo Clinic (18) · Memorial Sloan Kettering Cancer Center (13) · Roswell Park Cancer Institute (11) · City of Hope Medical Center (10) · Jonsson Comprehensive Cancer Center (9)

What is being tested here

Drugs under test in Waldenstrom Macroglobulinemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Rituximab9475
Bendamustine5010
Zanubrutinib409
Venetoclax307
Ibrutinib2525
Pirtobrutinib204
Epcoritamab202
Tacabrutideg202
Rocbrutinib202
Bortezomib1129

Drug classes tested here Tyrosine kinase inhibitors (TKIs) 14 open · Alkylating agents 5 open · Proteasome inhibitors 1 open · Corticosteroids 1 open · Immune checkpoint inhibitors 1 open

Coming up

3phase 3 studies under way
24studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 48 Waldenstrom Macroglobulinemia studies recruiting now, 44 (92%) set no upper age limit and 1 (2%) stop at 75 or younger. 2 (4%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.

Recruiting studies that take each age, of 48
AgeWomenMen
102 (4%)2 (4%)
1845 (94%)45 (94%)
3047 (98%)47 (98%)
4047 (98%)47 (98%)
5047 (98%)47 (98%)
6548 (100%)48 (100%)
7548 (100%)48 (100%)
8547 (98%)47 (98%)

Across all 524 studies, recruiting or not: 15% stop at 75 or younger and 6% at 65; 19% take children; 0% are for women only and 0% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Waldenstrom Macroglobulinemia studies take

Of 66 phase 2 interventional studies under Waldenstrom Macroglobulinemia, half reached primary completion within 64 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 156 mo38–80 · 50 studies—56 mo33–80 · 24 studies
Phase 1/272 mo50–114 · 25 studies——
Phase 264 mo45–103 · 66 studies—67 mo45–103 · 55 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Newly registered1

Studies

Recruiting first, then most recently updated. Showing 50 of 524. Browse all 524 → or search them.