Tympanic Membrane Perforation clinical trials
The registry lists 53 studies for Tympanic Membrane Perforation across more than 10 countries. 14 are recruiting or about to start. 45 of them are mainly about Tympanic Membrane Perforation (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05.
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Who runs them
Assiut University (8) · Shaikh Zayed Hospital, Lahore (2) · Grace Medical, Inc. (2) · HaEmek Medical Center, Israel (2) · D. Bradley Welling, MD, PhD (2) · Menzies School of Health Research (2) · Lund University (1) · Tympanogen (1)
What is being tested here
Drugs under test in Tympanic Membrane Perforation studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Dec 2026Effectiveness of Sequential Eustachian Tube Maneuvers in Hyperbaric Oxygen Conditions · Hospital Felicio Rocho
- Feb 2027Platelet-Rich Fibrin in Revision Cartilage Tympanoplasty · Bakirkoy Dr. Sadi Konuk Research and Training Hospital
- Oct 2027Does Adding a Fascial Layer to the Cartilage in Tympanoplasty for Large Tympanic Membrane Perforation Affect the Overall Results? · Assiut University
- Oct 2027Boomerang-Shaped Cartilage Graft in Endoscopic Tympanoplasty · Assiut University
- Oct 2027Effect of Autologous Serum-Soaked Paper Patch vs. Traditional Dry Paper Patch on Tympanic Membrane Perforations · Rawalpindi Medical College
- Nov 2027Outcomes of Cartilage Tympanoplasty in Children · Assiut University
Who these studies take
Of the 6 Tympanic Membrane Perforation studies recruiting now, 2 (33%) set no upper age limit and 2 (33%) stop at 75 or younger. 4 (67%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (50%) | 3 (50%) |
| 18 | 5 (83%) | 5 (83%) |
| 30 | 5 (83%) | 5 (83%) |
| 40 | 5 (83%) | 5 (83%) |
| 50 | 5 (83%) | 5 (83%) |
| 65 | 5 (83%) | 5 (83%) |
| 75 | 4 (67%) | 4 (67%) |
| 85 | 4 (67%) | 4 (67%) |
Across all 53 studies, recruiting or not: 49% stop at 75 or younger and 42% at 65; 49% take children; 4% are for women only and 0% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Stopped1
- Effectiveness of Silver Nitrate Cauterization vs Conservative Management in Tympanic Membrane Perforation ClosureTerminatedNov 2, 2026NCT07833670
Newly registered2
- Effect of Autologous Serum-Soaked Paper Patch vs. Traditional Dry Paper Patch on Tympanic Membrane PerforationsNov 3, 2026NCT07913087
- Platelet-Rich Fibrin in Revision Cartilage TympanoplastyOct 26, 2026NCT07893418
Studies
Recruiting first, then most recently updated. Showing 50 of 53. Browse all 53 → or search them.
- Effect of Autologous Serum-Soaked Paper Patch vs. Traditional Dry Paper Patch on Tympanic Membrane PerforationsNot yet recruitingNCT07913087Not applicable
- Platelet-Rich Fibrin in Revision Cartilage TympanoplastyRecruitingNCT07893418Not applicable1 country
- Outcomes of Cartilage Tympanoplasty in ChildrenNot yet recruitingNCT07866222Not applicable
- Does Adding a Fascial Layer to the Cartilage in Tympanoplasty for Large Tympanic Membrane Perforation Affect the Overall Results?Not yet recruitingNCT07834892Not applicable
- Boomerang-Shaped Cartilage Graft in Endoscopic TympanoplastyNot yet recruitingNCT07823894Not applicable
- Effectiveness of Sequential Eustachian Tube Maneuvers in Hyperbaric Oxygen ConditionsRecruitingNCT06408363Not applicable1 country
- Otological Study of Facial Cleft Patients Over 10 Years of Age (Excluding Isolated Cleft Lip) (EFEOF)Not yet recruitingNCT067389271 country
- Effect of Chitodex Gel in Tympanoplasty SurgeryRecruitingNCT06260618Not applicable1 country
- Tympanoseal Clinical StudyRecruitingNCT05849844Not applicable1 country
- Trans Canal Tympanoplasty With Local Anesthesia Using Fat Graft and "TachoSil"Not yet recruitingNCT06542367Not applicable
- Comparison of Topical Use of Platelet-rich Plasma Versus Hyaluronic Acid During Endoscopic Fat Graft Myringoplasty: a Randomized Clinical StudyNot yet recruitingNCT06505252Not applicable
- Microscopic Versus Endoscopic TympanoplastyNot yet recruitingNCT06257602
- Inhalational Anesthesia vs TIVA in Endoscopic TympanoplastyRecruitingNCT05993039Early Phase 11 country
- Effect of Ventilation Tubes in Otitis-prone ChildrenRecruitingNCT05348291Not applicable1 country
- Effectiveness of Silver Nitrate Cauterization vs Conservative Management in Tympanic Membrane Perforation ClosureTerminatedNCT07833670Not applicable1 country
- Audiometric Parameters in Conductive Hearing Loss and Middle Ear DiseaseWithdrawnNCT002224171 country
- Insulin Intratympanic ApplicationCompletedNCT07535827Early Phase 11 country
- Comparison of Results of Myringoplasty Using Biodesign - an Otologic Graft Made From Porcine Small Intestinal Submucosa, Temporalis Fascia, or Tragal Perichondrium - a Retrospective Cohort AnalysisCompletedNCT076981711 country
- Effect of Platelet-Rich Plasma on Eardrum Healing and Hearing After Tympanoplasty in AdultsCompletedNCT07664319Not applicable1 country
- In-office Repair of Chronic Tympanic Membrane PerforationsActive, not recruitingNCT06448039Phase 1/21 country
- A Prospective Comparative Study of Dry vs Wet Temporalis Fascia Graft in TympanoplastyCompletedNCT07595484Not applicable1 country
- Perf-Fix Study for Chronic Tympanic Membrane RepairCompletedNCT06083181Not applicable1 country
- Fibroblast Growth Factor Regeneration of Tympanic Membrane PerforationsCompletedNCT04960384Phase 21 country
- Biodesign® Otologic Repair GraftCompletedNCT046352282 countries
- Anatomical and Functional Results of Surgery of the Tympanic Membrane Perforation of the ChildCompletedNCT022969441 country
- Use of Biodesign® Otologic Graft in TympanoplastyWithdrawnNCT03904316Phase 41 country
- Fibroblast Growth Factor Regeneration of Tympanic Membrane PerforationsCompletedNCT02307916Phase 21 country
- Comparison of Postoperative Outcomes of Interlay vs Underlay Graft in TympanoplastyCompletedNCT07149480Not applicable1 country
- A Study to Assess ASP0598 Otic Solution Following Topical Application in the Ear in Subjects With Chronic Tympanic Membrane Perforation (CTMP)TerminatedNCT04305184Phase 1/21 country
- Tympanoseal (Tympanic Membrane Device) Clinical StudyCompletedNCT029189421 country
- Fat Graft Myringoplasty With and Without Platelet Rich Plasma (PRP) for Treating Smaller Tympanic Membrane PerforationsWithdrawnNCT01958749Not applicable2 countries
- Efficacy of Platelet Enriched Plasma in Preventing Surgery for Patients With Chronic Tympanic Membrane PerforationTerminatedNCT03837665Phase 1/21 country
- Effects of 100% Medical Grade Manuka Honey on Tympanic Membrane Reconstruction Healing.CompletedNCT05605262Phase 2/31 country
- Cartilage Versus Temporalis Fascia Graft in Tympanoplasty for Recurrent Tympanic Membrane Perforation '' Comparative Study ''Status unknownNCT05282810
- Composite Cartilage Perichondrium Graft for Air Bone Gap Closure in Chronic Suppurative Otitis Media (CSOM) Without Posterior Meatal FlapStatus unknownNCT05086718Not applicable1 country
- Hearing Results and Post Surgical Outcomes Using Amniotic Membrane Allograft vs. Fascia for TympanoplastyWithdrawnNCT03028272Not applicable
- Wide Frequency Band Test of Hearing in VeteransCompletedNCT020198881 country
- Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Middle Ear InfectionsStatus unknownNCT04761562Phase 2/31 country
- Tragal Perichondrium Versus Pretragal Fascial (SMAS) Graft for Endoscopic MyringoplastyStatus unknownNCT04687995Not applicable
- Repair of Tympanic Membrane Perforation Using Tachosil Under Local AnesthesiaStatus unknownNCT04428463Not applicable
- Endoscopic Tympanoplasty: Single Versus Double Flap TechniqueCompletedNCT03922295Not applicable1 country
- General Anesthesia With or Without Local Ear Block in Middle Ear SurgeriesCompletedNCT03569046Not applicable1 country
- Comparison Tympanoplasty With Membrane Amniotic and Autologous FasciaCompletedNCT03569969Not applicable
- The Anatomic Determinants of Perforation Induced Hearing LossWithdrawnNCT03271970
- Evaluation of Prognostic Factors in TympanoplastyStatus unknownNCT03416725
- Eustachian Tube Function and Myringoplasty/TympanoplastyTerminatedNCT017668561 country
- Endoscopic Overlay Tympanoplasty for TM PerforationCompletedNCT02331797Not applicable1 country
- A Study on the Regenerative Treatment of Tympanic Membrane With NPC-18 and FBG-18CompletedNCT02550314Phase 3
- Tympanoplasty Using Conchal Cavum Approach and Conchal PericondriumCompletedNCT02000843Not applicable1 country
- PneuMum: Pneumococcal Vaccination of Australian Indigenous MothersCompletedNCT00714064Phase 31 country