An interventional study of 50% Silver Nitrate Cauterization in Tympanic Membrane Perforation, sponsored by Muhammad Ali Javed. Terminated at 1 site in Pakistan. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-11-02.
Sponsored by Muhammad Ali Javed · Not applicable, Interventional, and Treatment
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The objective of this study is to evaluate the effectiveness of 50% silver nitrate chemical cauterization compared to conservative management (spontaneous healing) in closing small, dry tympanic membrane perforations. Patients presenting with a small (\<4 mm), dry, unilateral tympanic membrane perforation will be assigned to either receive weekly applications of 50% silver nitrate for up to 4 weeks or undergo observation for spontaneous healing. The primary outcome is to assess and compare the proportion of patients achieving complete tympanic membrane closure after 4 weeks of follow-up
Tympanic membrane perforation is a common clinical condition resulting primarily from middle ear infections or trauma. While small perforations can heal spontaneously, active intervention may be required to accelerate healing and prevent chronic complications. In this quasi-experimental comparative study conducted at the Department of Otorhinolaryngology, Rawalpindi Teaching Hospital, eligible participants aged 18 to 60 years with small, dry, unilateral pars tensa perforations are allocated into two groups based on clinical observation and patient preference: Intervention Group (Group A): Participants undergo microscopic cauterization using 50% silver nitrate applied to the perforation margins until blanching occurs, followed by Gel foam placement. This procedure is repeated weekly for up to 4 weeks. Control Group (Group B): Participants are managed conservatively to observe spontaneous healing without chemical intervention over 4 weeks. All participants are evaluated weekly for 4 weeks via otoscopic examination to monitor healing progress. Statistical analysis will compare total healing rates between groups and stratify for confounding variables such as age, gender, etiology, and initial perforation size.
53 studies on the registry are indexed under Tympanic Membrane Perforation; 14 are open to participants now.
This study's enrollment of 56 is close to the median of 57 across 39 interventional studies indexed under Tympanic Membrane Perforation.
Browse Tympanic Membrane Perforation studies →Muhammad Ali Javed is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
Microscopic application of 50% silver nitrate stick to the margins of the tympanic membrane perforation until blanching occurs, followed by Gel foam placement. Repeated weekly for up to 4 weeks
Drug: 50% Silver Nitrate Cauterization
Conservative management without active chemical or surgical intervention, observing for spontaneous healing over a 4-week period.
Under microscopic visualization, 50% silver nitrate is applied to the margins of the tympanic membrane perforation until blanching occurs, followed by Gel foam placement. The procedure is repeated weekly for up to 4 weeks.
Also known as: Chemical Cautery with Gel foam Patching
Tympanic Membrane Perforation Closure Rate
Proportion of participants achieving complete closure (healing) of the tympanic membrane without any residual defect, confirmed by otoscopic examination.
Time frame: 4 weeks post-treatment initiation
Plan to share: No
No publications or documents are linked to this record.
Ran from Feb 2026 to primary completion in Jul 2026, 5 months.
Since we started tracking on Sep 25, 2026, the dates moved once, on Nov 2, 2026: start Jan 2027 → Feb 2026, primary completion Jul 2027 → Jul 2026 and completion Aug 2027 → Aug 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is terminated, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Tympanic Membrane Perforation →
Muhammad Ali Javed