An interventional study of Cartilage Tympanoplasty in Tympanic Membrane Perforation, Conductive Hearing Loss and Chronic Otitis Media, sponsored by Assiut University. Not yet recruiting. Open to participants aged 8 Years to 18 Years. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by Assiut University · Not applicable, Interventional, and Treatment
This study evaluates the anatomical and hearing outcomes of cartilage tympanoplasty in pediatric patients with chronic tympanic membrane perforations.
A perforation (hole) in the eardrum in children can lead to recurrent ear discharge, chronic middle-ear infections, and conductive hearing loss. Cartilage tympanoplasty is a surgical technique that uses autologous cartilage (the patient's own cartilage tissue) to reconstruct and seal the eardrum. Cartilage is known for its rigidity and resistance to retraction, which may offer advantages in children who frequently experience middle-ear pressure and ventilation issues.
Children aged 8 to 18 years presenting with large, subtotal, or persistent dry central perforations will undergo cartilage tympanoplasty at Assiut University Hospitals. All participants will undergo standardized pre-surgical and post-surgical evaluations, including otological microscopic examinations and pure-tone audiometry tests.
The main objectives are to evaluate the graft success rate (complete anatomical closure and stability of the eardrum) and to measure functional hearing restoration, specifically changes in air-conduction thresholds and the air-bone gap (ABG).
45 studies on the registry are indexed under Tympanic Membrane Perforation; 10 are open to participants now.
This study's planned enrollment of 35 is below the median of 57 across 31 interventional studies indexed under Tympanic Membrane Perforation.
Browse Tympanic Membrane Perforation studies →Assiut University is the lead sponsor of 4,916 studies on the registry; 2,113 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Pediatric patients aged 8 to 18 years undergoing surgical repair of large, subtotal, or persistent central tympanic membrane perforations using autologous cartilage tympanoplasty to assess anatomical graft uptake and hearing restoration.
Procedure: Cartilage Tympanoplasty
Surgical reconstruction of the tympanic membrane using an autologous cartilage graft in pediatric patients presenting with large, subtotal, or persistent central perforations. The procedure is performed under general anesthesia to achieve complete anatomical closure of the perforation and restore middle-ear sound conduction.
Percentage of Participants With Complete Tympanic Membrane Closure
Assessed by otoscopic and microscopic examination. Complete closure is defined as an intact, fully epithelialized, and stable graft without residual perforation, graft retraction, or lateralization.
Time frame: 6 months postoperatively
No study locations are listed for this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Tympanic Membrane Perforation→
Assiut University