Thalassemia: all 422 studies

Page 3 of 5. Open to participants first (69), then studies with results posted, then the rest; newest registration first within each.

• Genetic Variants Affecting the Clinical Severity of Beta ThalassemiaStatus unknownNCT04918056
• Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe HemoglobinopathiesWithdrawnNCT04776850Early Phase 1
• A Study Investigate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Response of SLN124 in Adults With Alpha/Beta-thalassaemia and Very Low- and Low-risk Myelodysplastic SyndromeCompletedNCT04718844Phase 1
• Thalassemia Knowledge in Young People of IndonesiaStatus unknownNCT04706585
• Home-based Assessment of PRO Measures in SCD Using A Smartphone App Platform: A Feasibility StudyCompletedNCT04678037Not applicable
• Adherence to HU and HRQOL in Patients With Sickle Cell Disease: An Intervention Study Using HU-Go AppCompletedNCT04675645Not applicable
• Long-term Clinical Study of CN128 in Thalassemia PatientsCompletedNCT04614779Phase 2
• The Role of OCTA in Patients Affected by Beta ThalassemiaCompletedNCT04582110
• Frequency of COVID-19 Antibodies in Patients With Hereditary Hematological DiseasesCompletedNCT04526405
• Endocrine Function During Deferasirox TherapyCompletedNCT04515680
• Isoquercetin in Sickle Cell AnemiaWithdrawnNCT04474626Phase 2
• Congenital Heart Surgery in Pediatric Patients With Beta-Thalassemia MajorCompletedNCT04367701
• PK of SOF/LED in HCV - Infected Adolescents With Haematological DisordersStatus unknownNCT04353986Phase 3
• Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major ThalassemiaCompletedNCT04292314Phase 2/3
• The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia MajorCompletedNCT04260516Phase 1
• Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent Patients (THALA-RAP)Status unknownNCT04247750Phase 2
• Safety and Efficacy Evaluation of γ-globin Reactivated Autologous Hematopoietic Stem CellsCompletedNCT04211480Not applicable
• β-globin Restored Autologous HSC in β-thalassemia Major PatientsTerminatedNCT04205435Phase 1/2
• Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124WithdrawnNCT04176653Phase 1
• Phase 2a Pilot Study of NBMI Treatment in Patients With Beta Thalassemia Major, Requiring Iron ChelationCompletedNCT04092205Phase 2
• Choroidal Thickness in Beta-thalassemia PatientsCompletedNCT04067258
• Safety Study for Beta Thalassemia Subjects on PTG-300CompletedNCT04054921Phase 2
• Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical StudyCompletedNCT04009525Phase 4
• Apotransferrin in Patients With β-thalassemiaTerminatedNCT03993613Phase 2
• Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic PatientsCompletedNCT03992001Phase 4
• Observing the Changes of Endocrine and Metabolism in Patients With Thalassemia MajorStatus unknownNCT03951818
• The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia MajorCompletedNCT03948737Not applicable
• Anthropometric Measurements in Children Having Transfusion-dependent Beta ThalassemiaCompletedNCT03947632
• Short-term Clinical Study of CN128 in Thalassemia PatientsCompletedNCT03935633Phase 1
• Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant TransplantActive, not recruitingNCT03924401Phase 2
• Immunomodulatory Vitamin D in ThalassemiaCompletedNCT03919812Not applicable
• Resistance Exercise on Postprandial Hyperglycemia in Patients With B-thalassemia Exhibiting Resistance to InsulinCompletedNCT03889977Not applicable
• Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent PatientsCompletedNCT03877809Phase 2
• Red Cell Distribution Width Index Versus Red Cell Distribution Width as Discriminating Guide for Iron Deficiency Anaemia and Beta Thalassemia Trait .Status unknownNCT03868306
• Zinc Supplementation in Patients With β-Thalassemia Major Complicated With Diabetes MellitusCompletedNCT03851055Phase 3
• Sexual Maturation in β-Thalassemia Major Patients in Assiut University HospitalStatus unknownNCT03847558
• Detection Of β-thalassemia Carriers In AssiutStatus unknownNCT03822585Not applicable
• Study of PTG-300 in Non-Transfusion Dependent and Transfusion-Dependent Beta-Thalassemia Subjects With Chronic AnemiaCompletedNCT03802201Phase 2
• SP-420 in Subjects With Transfusion-dependent Beta-Thalassemia or Other Rare AnemiasWithdrawnNCT03801889Phase 2
• the Efficacy and Safety of Sugammadex in Children 0-2 Years OldStatus unknownNCT03728543Phase 2/3
• iHSCs With the Gene Correction of HBB Intervent Subjests With β-thalassemia MutationsStatus unknownNCT03728322Early Phase 1
• Cerebrovascular Reserve and White Matter Disease in Patients with Chronic AnemiaCompletedNCT03715972
• A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic DevelopmentCompletedNCT03687567
• Clinical Study of CN128 in Thalassemia PatientsCompletedNCT03673085Phase 1
• A Safety and Efficacy Study Evaluating CTX001 in Participants With Transfusion-Dependent β-ThalassemiaCompletedNCT03655678Phase 2/3
• Efficacy and Safety of Low Dose Thalidomide in Transfusion Dependent ThalassemiaCompletedNCT03651102Phase 2/3
• Pilot Study to Assess the Safety, PK and Iron Chelating Activity of DST-0509 (Deferasirox) in Thalassemia Patients Refractory to ChelationCompletedNCT03637556Phase 2
• Study of Thiotepa and TEPA Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant PatientsCompletedNCT03609840
• Study of Melphalan Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant PatientsCompletedNCT03609827
• Study of Clofarabine and Fludarabine Drug Exposure in Pediatric Bone Marrow Transplantation (HCT)CompletedNCT03609814
• The Use of CGMS to Detect Alterations of Blood Glucose in Thalassemic PatientsCompletedNCT03591900Not applicable
• Complications in Children With B- Thalassemia MajorStatus unknownNCT03462784
• L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary HypertensionStatus unknownNCT03402191Phase 4
• Study on the Mechanism of Colla Corri Asini in the Treatment of Thalassemia Patients With Pregnancy AnemiaStatus unknownNCT03392298Phase 4
• A Study With LJPC-401 for the Treatment of Myocardial Iron Overload in Patients With Transfusion-Dependent Beta ThalassemiaTerminatedNCT03381833Phase 2
• Colla Corii Asini Treating Anemia in Pregnant Women With Thalassemia(Presenting the Syndrome of Blood Deficiency)Status unknownNCT03374111Phase 4
• Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (HaploHCT) Following Reduced Intensity Conditioning (RIC) for Selected High Risk Non-Malignant DiseasesTerminatedNCT03367546Phase 2
• Quality of Life and Treatment Satisfaction in β-Thalassemia Patients Receiving DeferasiroxStatus unknownNCT03358498
• Periodontal Therapy in Thalassemia Major PatientsCompletedNCT03311243Not applicable
• Gene Therapy for Beta-Thalassemia Major Using Autologous Hematopoietic Stem Cell Genetically ModifiedStatus unknownNCT03276455Phase 1/2
• Long-term Follow-up of Subjects Treated With OTL-300 for Transfusion Dependent Beta-thalassemia Study (TIGET-BTHAL)Active, not recruitingNCT03275051Not applicable
• A Study of Bitopertin (RO4917838) in Adults With Non-Transfusion-Dependent (NTD) Beta-ThalassemiaCompletedNCT03271541Phase 2
• A Blood Stem Cell Transplant for Sickle Cell DiseaseActive, not recruitingNCT03249831Phase 1
• Thalassemia Treatment Based on the Stem Cell TechnologyStatus unknownNCT03222453Not applicable
• The Effective and Safety of Thalidomide in TIStatus unknownNCT03184844Phase 2
• A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCTCompletedNCT03176849Phase 4
• Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia MajorStatus unknownNCT03171831Phase 4
• Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia PatientsCompletedNCT03170245
• Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 702843 Administered Subcutaneously to Healthy VolunteersCompletedNCT03165864Phase 1
• Evaluation of Nutritional Status in Thalassemia Major Patients in Assiut Children HospitalCompletedNCT03161899
• Erythrocyte Glutamine Level Relation to Pulmonary Hypertension Risk in Beta Thalassemia Major ChildrenCompletedNCT03133169
• Zinc Supplementation on Cellular Immunity in Thalassemia MajorCompletedNCT03117192Phase 4
• Monitoring of Chimerism After Transplantation in Patients With β Thalassemia Major and the Treatment Strategies for the Reduction of ChimerismStatus unknownNCT03101423Not applicable
• Pneumococcal Vaccination for Splenectomised Thalassemia Major Patients in IndonesiaCompletedNCT03095326Phase 4
• Denosumab Versus Zoledronic Acid in Thalassemia-Induced OsteoporosisTerminatedNCT03040765Phase 3
• Sofosbuvir/Ledipasvir for Hepatitis C Genotype 1-6 in Patients With Transfusion-Dependent Thalassemia: An Open Label TrialCompletedNCT03032666Phase 4
• Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?Status unknownNCT03014882Phase 1/2
• A Study of IMR-687 in Healthy Adult VolunteersCompletedNCT02998450Phase 1
• The Effective and Safety of Thalidomide in NTDTStatus unknownNCT02995707Phase 2
• In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)TerminatedNCT02986698Phase 1
• The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia MajorStatus unknownNCT02984475Phase 4
• A Study of EPEG in Beta Thalassemia PatientsCompletedNCT02950857Phase 1
• The Prevalence and Severity of HCV Infection in Thalassemia Major and Thalassemia Intermedia in Siriraj HospitalCompletedNCT02904252
• Benefits of Nigella Sativa in Children With Beta Thalassemia MajorStatus unknownNCT02816957Early Phase 1
• Therapeutic Effect of Colla Corii Asini on Improving Anemia and Hemoglobin Composition in Pregnant Women With ThalassemiaStatus unknownNCT02772016Early Phase 1
• Study of The Therapeutic Benefits of Al-hijamah in Children With Beta Thalassemia MajorStatus unknownNCT02761395Not applicable
• Effect of Spirulina on Liver Iron Concentration in Beta Thalassemic Children With Hepatitis CCompletedNCT02744560Not applicable
• Effect of Spirulina on Serum Hyaluronic Acid in Beta Thalassemic Children With Hepatitis CCompletedNCT02744547Not applicable
• Effect of Spirulina on Liver Fibrosis by Transient Elastography in Beta Thalassemic Children With Hepatitis CCompletedNCT02744105Not applicable
• the Potential Immunomodulatory Effects of Spirulina on Thalassemic ChildrenCompletedNCT02674607Not applicable
• Effect of Spirulina Compared to Amlodipine on Cardiac Iron Overload in Children With Beta ThalassemiaCompletedNCT02671695Not applicable
• Long-term Follow-up of Subjects With Transfusion-Dependent β-Thalassemia (TDT) Treated With Ex Vivo Gene TherapyActive, not recruitingNCT02633943
• To Document the Burden of Illness on the Quality of Life and the Impact on Healthcare Utilization in (Beta) β-thalassemia Subjects Who Are Transfusion Dependent (TD) and Non-transfusion Dependent (NTD) Receiving Standard of CareCompletedNCT02626689
• Effects of Spirulina on Cardiac Functions in Children With Beta Thalassemia MajorCompletedNCT02597595Not applicable
• Denosumab vs Placebo in Patients With Thalassemia Major and OsteoporosisCompletedNCT02559648Phase 2
• Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia PatientsStatus unknownNCT02474420Not applicable
• Gene Therapy for Transfusion Dependent Beta-thalassemiaStatus unknownNCT02453477Phase 1/2
• B-Thalasaemia Trait and Its Possible Cardioprotective RoleStatus unknownNCT02428023
• CINC424A2X01B Rollover ProtocolActive, not recruitingNCT02386800Phase 4
• Dose-Escalation Study of SCD-101 in Sickle Cell DiseaseStatus unknownNCT02380079Phase 1

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