An observational study in Thalassemia,Embryonic Development,Reproductive Sterility and Infertility, sponsored by Reproductive & Genetic Hospital of CITIC-Xiangya. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2022-01-11.
Sponsored by Reproductive & Genetic Hospital of CITIC-Xiangya · Observational
Thalassemia is an anemia or pathological state caused by compounding absently or inadequately of one or more globin chains of hemoglobin due to the defects of the globin gene,and the carrying rate is high in southern China. Although there are many studies of Thalassemia, the relationship between the globin gene defects and the early embryo development has not been reported.
This study intends to carry out a retrospective analysis on the embryonic development of the patients with thalassemia assisted by PGD from January 1, 2011 to now in our hospital, to explore whether the HBA or HBB gene defects have a certain influence on the early embryo development, so as to accumulate certain data for reproductive health research.
2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.
This study's enrollment of 737 is above the median of 200 across 714 observational studies indexed under Infertility.
Browse Infertility studies →Reproductive & Genetic Hospital of CITIC-Xiangya is the lead sponsor of 26 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
One or both of infertility couples with thalassemia take PGD treatment.
Exclusion Criteria:
alpha-Thalassemia
Procedure: Preimplantation genetic diagnosis
beta-Thalassemia
Procedure: Preimplantation genetic diagnosis
Gardner grading of blastocysts
development status of blastocysts
Time frame: embryo cultured in-vitro for 5-7 days
Plan to share: Undecided
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This study is completed, as verified in Dec 2021. You cannot join it, but the record below documents what was studied.
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Reproductive & Genetic Hospital of CITIC-Xiangya