Thalassemia: all 422 studies

Page 2 of 5. Open to participants first (69), then studies with results posted, then the rest; newest registration first within each.

• Study to Evaluate the Safety and Efficacy of Luspatercept (ACE-536) in Participants With Beta-thalassemia (A536-04/MK-6143-002)CompletedNCT01749540Phase 2Results posted
• A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major ParticipantsCompletedNCT01745120Phase 1/2Results posted
• An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study)CompletedNCT01736540Phase 4Results posted
• Efficacy and Safety Study of Deferasirox in Patients With Non-transfusion Dependent ThalassemiaCompletedNCT01709838Phase 4Results posted
• Combination Deferasirox and Deferiprone for Severe Iron Overload in ThalassemiaCompletedNCT01709032Phase 1/2Results posted
• Post Hematopoietic Stem Cell TransplantationCompletedNCT01610297Phase 4Results posted
• Allogeneic SCT of NiCord®, UCB-Derived Ex Vivo Expanded Stem and Progenitor Cells, in Patients With HemoglobinopathiesCompletedNCT01590628Phase 1/2Results posted
• Study to Determine the Safety and Tolerability of Sotatercept (ACE-011) in Adults With Beta( β)- Thalassemia.TerminatedNCT01571635Phase 2Results posted
• Effects of Transfusion of Older Stored Red CellsTerminatedNCT01534676Not applicableResults posted
• Safety and Efficacy of Deferasirox in Combination With Desferoxamine in β-thalassaemia Patients With Severe Cardiac Iron OverloadTerminatedNCT01459718Phase 2Results posted
• Safety, Efficacy and Pharmacokinetics of an Oral Iron Chelator Given for a Year to Pediatric Patients With Iron OverloadTerminatedNCT01363908Phase 2Results posted
• Treatment of Sickle Cell Anemia With Stem Cell TransplantTerminatedNCT01350232Not applicableResults posted
• Alefacept and Allogeneic Hematopoietic Stem Cell TransplantationTerminatedNCT01319851Not applicableResults posted
• Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron OverloadCompletedNCT01186419Phase 2Results posted
• A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemiaCompletedNCT01179217Phase 3Results posted
• Glutamine Therapy for Hemolysis-Associated Pulmonary HypertensionCompletedNCT01048905Phase 2Results posted
• Reduced Intensity Transplant Conditioning Regimen for Severe ThalassemiaCompletedNCT01005576Phase 2Results posted
• Haploidentical PBMC Transplant for Severe Congenital AnemiasActive, not recruitingNCT00977691Phase 1/2Results posted
• Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCsCompletedNCT00957931Phase 2Results posted
• Combined Chelation Therapy in Patients With Transfusion Dependent Thalassemia and Iron OverloadCompletedNCT00901199Phase 2Results posted
• Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron Overload and a One Year Open-label Extension StudyCompletedNCT00873041Phase 2Results posted
• Assessment of Pain in People With Thalassemia Who Are Treated With Regular Blood TransfusionsCompletedNCT00872833Results posted
• Assessment of Pain in People With ThalassemiaCompletedNCT00872339Results posted
• Sildenafil to Improve Exercise Capacity in People With Thalassemia and Pulmonary HypertensionCompletedNCT00872170Phase 2/3Results posted
• Pilot Study for Patients With Poor Response to DeferasiroxCompletedNCT00749515Phase 4Results posted
• Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant DisordersCompletedNCT00744692Phase 1Results posted
• Evaluating the Safety and Effectiveness of Decitabine in People With Thalassemia IntermediaCompletedNCT00661726Phase 2Results posted
• Assess the Feasibility and Safety of Granulocyte Colony Stimulating Factor (GCSF) Mobilization of CD34+ Hematopoietic Progenitor Cells in Patients With Betathalassemia MajorCompletedNCT00658385Not applicableResults posted
• L-Glutamine Therapy for Sickle Cell AnemiaTerminatedNCT00586209Phase 2Results posted
• Allogeneic Stem Cell Transplantation, Severe Homzygous 0/+Thalassemia or Sever Variants of Beta 0/+ Thalassemia, THALLOTerminatedNCT00578292Not applicableResults posted
• Zinc & Bone Health in Thalassemia: The Think Zinc StudyCompletedNCT00459732Not applicableResults posted
• Cardiac T2* in Beta-thalassemia Patients on Deferasirox TreatmentCompletedNCT00447694Phase 2Results posted
• A Pilot Study of HSCT for Patients With High-risk Hemoglobinopathy Using a Nonmyeloablative Preparative RegimenCompletedNCT00427661Not applicableResults posted
• A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload.CompletedNCT00390858Phase 2Results posted
• Extension Study of Iron Chelation Therapy With Deferasirox in β-thalassemia and Rare Chronic Anemia PatientsCompletedNCT00303329Phase 2Results posted
• Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron OverloadCompletedNCT00235391Phase 3Results posted
• Stem Cell Transplant for HemoglobinopathyCompletedNCT00176852Phase 2/3Results posted
• Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration)CompletedNCT00171301Phase 4Results posted
• An Extension Study of Iron Chelation Therapy With Deferasirox (ICL670) in β-thalassemia Patients With Transfusional Iron OverloadCompletedNCT00171210Phase 3Results posted
• Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With HemoglobinopathiesCompletedNCT00153985Phase 2Results posted
• L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 ThalassemiaCompletedNCT00125788Phase 2Results posted
• Combination Therapy Compared With Single-Drug Therapy in Patients With Cardiac DiseasesTerminatedNCT00115349Phase 2Results posted
• Prevalence of Abnormal Haemoglobin Variants in Metropolitan Chattogram, BangladeshCompletedNCT07305181
• Effect of L-Glutamine on Pulmonary Artery Pressure in Patients With Non-Transfusion-Dependent ThalassemiaCompletedNCT07210450Phase 2/3
• Prevalence and Hematological Characteristics of HemoglobinopathiesCompletedNCT07180836
• Impact of Virtual Reality on Pain and Anxiety During Intravenous Cannulation Procedures Among Thalassemia Patients in UAE.CompletedNCT07099196Not applicable
• Effect of Exercise on Body Composition and Bone Health in Patients With ThalassemiaActive, not recruitingNCT07064941Not applicable
• A Study on the Effect of Etavopivat on Heart Rhythm in Healthy ParticipantsCompletedNCT07023029Phase 1
• Observational Study: Hetrombopag for Platelet Recovery in Haploidentical HSCTCompletedNCT07003269
• Observational Study: Romiplostim for Platelet Recovery in Haploidentical HSCTCompletedNCT07003256
• Growth Evaluation, Health Promotion, and Clinical Management in Children and Adolescents With ThalassemiaActive, not recruitingNCT06931912Not applicable
• Study to Evaluate the Long- Term Safety and Efficacy of Luspatercept in Subjects Who Received at Least One Dose of Luspatercept in the Compassionate Use PhaseActive, not recruitingNCT06913634
• Pregnancy and Childbirth in Women with Thalassemia Yesterday and TodayCompletedNCT06889727
• Safety and Efficacy of Immunomodulator Drug Thalidomide in Multi-transfused Thalassemia PatientsCompletedNCT06888232Not applicable
• To Evaluate Long- Term Safety and Efficacy of LuspaterceptActive, not recruitingNCT06875219
• ERN-EuroBloodNet Registry on Patients with Rare Red Blood Cell Defects and COVID-19CompletedNCT06831799
• A Research Study of the Effect of Etavopivat on Other Drugs in Healthy ParticipantsCompletedNCT06813924Phase 1
• Development of THALEA Kit and Its Impact on Knowledge, Attitude, and Intention for Premarital Thalassemia ScreeningActive, not recruitingNCT06800495Not applicable
• A Real-World Study of β-Thalassemia Major Treatment With Luspatercept in TaiwanActive, not recruitingNCT06596642
• A Research Study Looking at a Single Dose of Etavopivat in Healthy Chinese ParticipantsCompletedNCT06581627Phase 1
• Vitamin E Supplementation for Children With Transfusion Dependent Beta Thalassemia on Different Iron Chelation RegimenCompletedNCT06509581Not applicable
• Long Term Beta Thalassemia Treatment: Findings From The Extension PeriodActive, not recruitingNCT06490601Phase 2
• Comparison of Deferasirox and Desferoxamine in Patients of β-Thalassemia Major With Iron OverloadCompletedNCT06468423Not applicable
• A Research Study of the Effect of Food on Etavopivat in Healthy ParticipantsCompletedNCT06433661Phase 1
• Comparison Of Efficacy And Safety Of Thalidomide Vs Hydroxyurea In Thalassemia Patients: A Single-Centre Pilot Study.CompletedNCT06239389Phase 2
• Pharmacotherapy Prescribing Pattern and the Adherence Level to Iron Chelation Therapy in ThalassemiaCompletedNCT06210139
• The Effect of Acupressure on Pain in Children With ThalassemiaCompletedNCT06163196Not applicable
• Thalidomide and Hydroxyurea Combination in β-Thalassemia PatientsCompletedNCT06153784Phase 2/3
• Deciphering Effects of Thalidomide on Red Blood Cells in Transfusion Dependents Beta Thalassemia PatientsCompletedNCT06146478Phase 3
• Safety & Efficacy of Thalidomide in Children With Transfusion Dependent ThalassemiaCompletedNCT06098014Phase 1
• Cardiac Management of Patients With Thalassemia Minor and Breast CancerCompletedNCT05960214
• NAC Effect on Iron Overload and Blood Transfusion in β-thalassemia MajorStatus unknownNCT05777733Phase 1
• A Study to Evaluate the Safety and Efficacy of ET-01 Transplantation in Subjects with Transfusion Dependent Β-Thalassaemia.TerminatedNCT05752123Not applicable
• Benson's Relaxation Technique, Music Therapy for Children With ThalassemiaCompletedNCT05730374Not applicable
• Clinical Study to Evaluate the Possible Efficacy and Safety of L- Carnitine and Sildenafil in Children Having Beta Thalassemia With Increased Tricuspid Regurgitant Jet VelocityStatus unknownNCT05584956Phase 3
• Thalassemia Screening by Third Generation SequencingStatus unknownNCT05552690Not applicable
• Assessment of Nutritional Status and Role of Insulin-like Growth Factor-1 in ChildrenCompletedNCT05529550
• Correlation Between Pulmonary Functions and Physical Fitness in Children With β-thalassemiaStatus unknownNCT05494333
• Assessment of Cognitive Function, Fatigue and Health Related Quality of Life in Children With Beta ThalassemiaCompletedNCT05469230
• The Safety and Efficiency of Luspatercept in Chinese Adults With Transfusion Dependent β-thalassemia: a Real-world StudyStatus unknownNCT05462548Phase 4
• EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT)Active, not recruitingNCT05444894Phase 1/2
• Safety and Efficacy Evaluation of γ-globin Reactivated Autologous Hematopoietic Stem CellsSuspendedNCT05442346Not applicable
• Hemoglobinopathy Nursing Program and Pediatric Nursing StudentsCompletedNCT05389891Not applicable
• The Prevelence of IVS 1-6 (T-C) [HBB:c.92 +6 T-C] Gene Mutation in Suspected Cases of β Thalassemia in Assiut University HospitalsStatus unknownNCT05370677
• Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dependent β-Thalassemia (TDT)Active, not recruitingNCT05356195Phase 3
• Long-term Clinical Study of CN128 in Thalassemia With Sever Liver Iron Overloaded PatientsCompletedNCT05355766Phase 2
• Inhibitory Effect of a Polyphenol Supplement on Dietary Iron Absorption in Adults with ThalassemiaCompletedNCT05326503Not applicable
• Study on the Effect of Different Risk Factors on the Growth Parameters of Thalassemic Patients in Assiut (AUCH)Status unknownNCT05303506
• Red Blood Cell - IMProving trAnsfusions for Chronically Transfused RecipientsCompletedNCT05255445
• The Prevelence of HBB c.93-21 G-A in β Thalassemia PatientsStatus unknownNCT05133388
• Clinical Experience of Thalidomide in Thalassemic PatientsCompletedNCT05132270Phase 2/3
• Assessment of Cognitive Functions, Psychological Symptoms, and Quality of Life Among B Thalassemia Patients and Their Clinical Correlates.Status unknownNCT05105659
• Efficacy of Transdermal Microneedle Patch for Topical Anesthesia Enhancement in Paediatric Thalassemia PatientsCompletedNCT05078463Phase 2
• A Study Evaluating the Safety and Efficacy of the BD211 Drug Product in β-Thalassemia Major ParticipantsCompletedNCT05015920Not applicable
• A Study of Etavopivat in Patients With Thalassemia or Sickle Cell DiseaseCompletedNCT04987489Phase 2
• Study to Evaluate Additional Risk Minimisation Measures (aRMMs) for REBLOZYL Among Healthcare Professionals (HCPs)CompletedNCT04973280
• Thrombin Generation in Beta-thalassemia MajorStatus unknownNCT04962984Not applicable
• Iron Status in BTM With Blood TransfusionStatus unknownNCT04947540
• Efficacy and Safety Study of Multiple Doses of VIT-2763 in Adults With Transfusion-dependent Beta-thalassemiaWithdrawnNCT04938635Phase 2
• A Safety and Efficacy Study Evaluating ET-01 in Subjects with Transfusion Dependent Β-ThalassaemiaTerminatedNCT04925206Phase 1

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