Synucleinopathies clinical trials
The registry lists 36 studies for Synucleinopathies across more than 10 countries. 22 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-22.
Status
- Recruiting
- 18
- Completed
- 8
- Enrolling by invitation
- 2
- Not yet recruiting
- 2
- Active, not recruiting
- 2
- Status unknown
- 2
Phase
- Phase 2
- 6
- Early Phase 1
- 2
- Phase 1
- 1
- Phase 3
- 1
Where
- United States
- 9
- China
- 7
- Hong Kong
- 4
- Italy
- 4
- Denmark
- 4
- Canada
- 2
Who runs them
Chinese University of Hong Kong (4) · Danish Research Centre for Magnetic Resonance (3) · Fujian Medical University Union Hospital (2) · Radboud University Medical Center (2) · Ruijin Hospital (1) · Fondazione Don Carlo Gnocchi Onlus (1) · Invicro (1) · Skane University Hospital (1)
Studies
Recruiting first, then most recently updated. Showing 36 of 36 — search for more.
- A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)RecruitingNCT07589595Phase 24 countries
- Alpha-Synuclein PET/CT in Various α-Syn-Related DiseaseRecruitingNCT069496701 country
- Neurodegenerative Diseases Progression Markers (MARKERS-NDD)RecruitingNCT065967461 country
- Autologous suraL nervE Grafting to the Substantia nigrA in Patients With SynuclienopathiesRecruitingNCT06683365Phase 11 country
- rTMS as an Intervention for Levodopa-induced DyskinesiaRecruitingNCT06570824Not applicable1 country
- Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-NetherlandsRecruitingNCT06193252Not applicable1 country
- Slow-SPEED: Slowing Parkinson's Early Through Exercise DosageRecruitingNCT06993142Not applicable2 countries
- A Comprehensive, Multimodal Characterization of Prodromal PD in Subjects With RBDRecruitingNCT077907441 country
- An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD)RecruitingNCT06996652Phase 22 countries
- Study of Axial and Cognitive Symptoms and Biomarkers of Neurodegeneration in Brain-first and Body-first PDRecruitingNCT071878431 country
- The Swedish BioFINDER Sleep StudyRecruitingNCT075337991 country
- prTMS as an Intervention for Bradykinesia in Parkinson's DiseaseRecruitingNCT07397377Not applicable1 country
- Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical ActivityRecruitingNCT07324330Not applicable1 country
- Application of 18F-CP6A PET Imaging in SynucleinopathiesNot yet recruitingNCT06827821Early Phase 11 country
- Tenapanor in Synucleinopathy-Related ConstipationRecruitingNCT06460038Phase 21 country
- Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous SystemEnrolling by invitationNCT067450111 country
- North American Prodromal Synucleinopathy ConsortiumEnrolling by invitationNCT036236722 countries
- Digital Diagnostics and Intervention Services for Parkinson's DiseaseNot yet recruitingNCT06534177
- Gut Microbiota in the Progression of Alpha-synucleinopathiesRecruitingNCT053538681 country
- Efficacy and Safety of Astragalus for Non-motor Symptoms of α-SynucleinopathyRecruitingNCT05506891Phase 21 country
- Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement DisordersRecruitingNCT054868061 country
- A Registered Cohort Study on α-SynucleinopathyRecruitingNCT055270671 country
- Toward Molecular Profiling of Parkinson's Disease in Easily Accessible Biological MatricesActive, not recruitingNCT07480187Not applicable1 country
- Microstructural and Sodium 7 Tesla Brain MRI in Idiopathic REM Sleep Behaviour DisorderCompletedNCT05976971Not applicable1 country
- A Clinical Study of the Efficacy of Idebenone in the Treatment of iRBD Into SynucleinopathiesActive, not recruitingNCT04534023Phase 21 country
- A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With SynucleinopathiesTerminatedNCT040201981 country
- Study to Evaluate a Potential PET Radioligand for Imaging Alpha-synuclein Deposits in the BrainCompletedNCT06445465Early Phase 11 country
- Efficacy and Safety of Rasagiline in Prodromal Parkinson's DiseaseWithdrawnNCT05611372Phase 2/3
- An Observational Study of Parkinson's Disease and Other Synucleinopathies (EASE-PD)CompletedNCT056388151 country
- Gut Microbiota Across Early Stages of Synucleinopathy: From High-risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's DiseaseCompletedNCT036452261 country
- Study of 18F-0502B PET Imaging Targeting α-synuclein in the Diagnosis of α-synuclein-related DiseasesStatus unknownNCT057578041 country
- Prodromal Markers of First-degree Relatives of Patients With Psychiatric Disorders Comorbid With RBDCompletedNCT035954751 country
- Intensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's DiseaseStatus unknownNCT05452655Not applicable1 country
- Progression of Prodromal Markers of α-synucleinopathy Neurodegeneration in the FDRs of Patients With RBDCompletedNCT036717721 country
- Post-prandial Hypotension and Sleepiness in Parkinson's Disease and Other SynucleinopathiesCompletedNCT02021903Not applicable1 country
- Exploring the Relationship Between Alpha-synucleinopathy Related Non-motor Symptom and Post-op. Delirium in Elderly Patients With Spine SurgeryCompletedNCT025506261 country