An observational study in α-synucleinopathy, sponsored by Fujian Medical University Union Hospital. Recruiting at 1 site in China. Open to participants aged 30 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-03-23.
Sponsored by Fujian Medical University Union Hospital · Observational
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom. The data to be collected is intended to help healthcare providers make important medical decisions concerning α-synucleinopathy, through an enhanced understanding of the natural history, progression and multi-omics datasets of α-synucleinopathy.
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom, including Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with lewy bodies (DLB). The data to be collected is intended to help healthcare providers make important medical decisions concerning α-synucleinopathy, through an enhanced understanding of the natural history, progression and multi-omics datasets of α-synucleinopathy. Datas will be accumulated retrospectively at research entry and prospectively during follow up.
38 studies on the registry are indexed under Synucleinopathies; 23 are open to participants now.
This study's planned enrollment of 500 is above the median of 100 across 16 observational studies indexed under Synucleinopathies.
Browse Synucleinopathies studies →Fujian Medical University Union Hospital is the lead sponsor of 109 studies on the registry; 79 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Participants with a clinical diagnosis of PD, DLB and MSA.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants with clinical diagnosis of α-synucleinopathy.
Other: Data collection
Healthy controls
Other: Data collection
Neuropsychological assessment, brain MRI, electroencephalogram and biomarker datas will be collected
Neuropsychological assessment, brain MRI, electroencephalogram and biomarker datas will be collected
UPDRS /UMSARS scores
Disease severity was evaluated by the neurologist using the united Parkinson's disease rating scale (UPDRS) or united multiple system atrophy rating scale (UMSARS) separately as diagnosed.
Time frame: Baseline
H&Y stage
The Hoehn and Yahr （H\&Y)
Time frame: Baseline
MoCA scores
The Montreal Cognitive Assessment (MoCA)
Time frame: Baseline
ACE-III scores
Addenbrooke's Cognitive Examination (ACE) score
Time frame: Baseline
Mean arterial pressure after 3 minutes of upright posture versus decubitus position (mmHg)
Mean arterial pressure was calculated as ⅓ pulse pressure + diastolic pressure.
Time frame: Baseline
HRV (ms)
Heart rate variability (HRV) was calculated as the maximum bpm - minimum bpm.
Time frame: Baseline
Plasma α-synuclein levels (ng/ml)
Time frame: Baseline
Vic
The intra-cellular compartment (Vic) of the Neurite Orientation Dispersion and Density Imaging (NODDI) model represents diffusion within the axons and cells.
Time frame: Baseline
PAF (Hz)
The alpha-peak frequency (PAF) is the frequency with the highest power within the alpha-band.
Time frame: Baseline
Vic
The intra-cellular compartment (Vic) of the Neurite Orientation Dispersion and Density Imaging (NODDI) model represents diffusion within the axons and cells.
Time frame: 1 year after Baseline
Plan to share: No
No publications or documents are linked to this record.
Started Sep 2021 (actual). Primary completion is estimated for Jun 2030, 105 months after the start.
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Fujian Medical University Union Hospital →