REM Sleep Behavior Disorder clinical trials
The registry lists 101 studies for REM Sleep Behavior Disorder across more than 10 countries. 45 are recruiting or about to start. 51 of them are mainly about REM Sleep Behavior Disorder (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Chinese University of Hong Kong (11) · University Hospital, Clermont-Ferrand (6) · Seoul National University Hospital (5) · Cedars-Sinai Medical Center (3) · Mayo Clinic (3) · Ruijin Hospital (3) · University of Minnesota (2) · Washington University School of Medicine (2)
What is being tested here
Drugs under test in REM Sleep Behavior Disorder studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026DaTSCAN Imaging in Aging and Neurodegenerative Disease · Mayo Clinic
- Dec 2026Behavioral Treatment for Nightmares in REM Sleep Behavior Disorder · University of Utah
- Dec 2026Natural History Study of Synucleinopathies · NYU Langone Health
- Dec 2026IMPACT 360 for Parkinson's Disease · University of British Columbia
- Dec 2026Development and Online Evaluation of an Online Course for Parasomnias · University of Manitoba
- Dec 2026The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders · Second Affiliated Hospital of Soochow University
- Mar 2027Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease · Cambridge University Hospitals NHS Foundation Trust
- Apr 2027Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease · CND Life Sciences
- May 2027North American Prodromal Synucleinopathy Consortium Stage 2 · Washington University School of Medicine
- Jun 2027The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions · University of Cambridge
Who these studies take
Of the 32 REM Sleep Behavior Disorder studies recruiting now, 18 (56%) set no upper age limit and 4 (13%) stop at 75 or younger. 4 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 17 (53%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (13%) | 4 (13%) |
| 18 | 16 (50%) | 16 (50%) |
| 30 | 17 (53%) | 17 (53%) |
| 40 | 20 (63%) | 20 (63%) |
| 50 | 29 (91%) | 29 (91%) |
| 65 | 32 (100%) | 32 (100%) |
| 75 | 30 (94%) | 30 (94%) |
| 85 | 24 (75%) | 24 (75%) |
Across all 101 studies, recruiting or not: 16% stop at 75 or younger and 7% at 65; 7% take children; 0% are for women only and 0% for men only; 50% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's DiseaseOct 20, 2026NCT07882108
Studies
Recruiting first, then most recently updated. Showing 50 of 101. Browse all 101 → or search them.
- An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD)RecruitingNCT06996652Phase 22 countries
- Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's DiseaseRecruitingNCT07882108Not applicable1 country
- Artificial Intelligence-based Parkinson's Disease Risk Assessment (AI-PRA) StudyNot yet recruitingNCT077068293 countries
- A Comprehensive, Multimodal Characterization of Prodromal PD in Subjects With RBDRecruitingNCT077907441 country
- Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-NetherlandsRecruitingNCT06193252Not applicable1 country
- Neuroplasticity in RBDRecruitingNCT054719601 country
- The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological ConditionsRecruitingNCT07786116Not applicable1 country
- MIBG in Aging and Neurologic DisordersEnrolling by invitationNCT05514106Phase 41 country
- PET-MRI of Reward System in Parkinson's Disease With RBDRecruitingNCT07213219Not applicable1 country
- L-THEANINE AND MEDITERRANEAN DIET ON RBD, GI FUNCTION, AND INFLAMMATION IN PARKINSON'S DISEASERecruitingNCT07682532Not applicable1 country
- Natural History Study of SynucleinopathiesRecruitingNCT017999154 countries
- The COSP-RBD Study: Concussions and Contact Sports in RBD vs ControlsRecruitingNCT062702901 country
- Intestinal Immunity in Neurologic DiseaseRecruitingNCT063294531 country
- North American Prodromal Synucleinopathy Consortium Stage 2Enrolling by invitationNCT058264572 countries
- Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and NeuroimagingNot yet recruitingNCT07474779Not applicable1 country
- Pain Assessment in Patients With Idiopathic Rapid Eye Movement (REM) Sleep Behaviour DisorderRecruitingNCT07365566Not applicable1 country
- INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity InterventionNot yet recruitingNCT07288593Not applicable1 country
- A Multimodal Prospective Cohort Study of ParkinsonismRecruitingNCT075538451 country
- The Swedish BioFINDER Sleep StudyRecruitingNCT075337991 country
- Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic DisordersRecruitingNCT07509125Not applicable1 country
- Implementing a National Biobank of PD With WGS and Functional Assessment of Polygenic Inheritance by iPSC TechnologyRecruitingNCT057219111 country
- Unmet Needs Among Patients With Isolated REM Sleep Behavior Disorder (iRBD) and Their Significant OthersRecruitingNCT074984521 country
- Behavioral Treatment for Nightmares in REM Sleep Behavior DisorderRecruitingNCT06441864Not applicable1 country
- DaTSCAN Imaging in Aging and Neurodegenerative DiseaseEnrolling by invitationNCT01453127Phase 41 country
- Study of Sleep Disorders in Prodromal and Definite Parkinsons DiseaseRecruitingNCT06582121Not applicable1 country
- Role of Slow Waves in the Progression of Neurodegeneration in Isolated REM Sleep Behavior DisorderRecruitingNCT07355842Not applicable1 country
- Development and Online Evaluation of an Online Course for ParasomniasRecruitingNCT07361315Not applicable1 country
- Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MRRecruitingNCT052052911 country
- Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic InsomniaNot yet recruitingNCT06644573Phase 11 country
- The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake DisordersRecruitingNCT06797284Not applicable1 country
- Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous SystemEnrolling by invitationNCT067450111 country
- Multimodal Image Technologies Investigate the Role and Mechanism of Probiotics in Improving RBD with Parkinson's DiseaseRecruitingNCT06710574Phase 41 country
- Artificial Intelligence in Molecular Imaging: Predicting Parkinson's Risk in REM Sleep Behavior DisorderRecruitingNCT06629207Not applicable1 country
- North American Prodromal Synucleinopathy ConsortiumEnrolling by invitationNCT036236722 countries
- Effect of Acupuncture for Rapid Eye Movement Sleep Behavior DisorderNot yet recruitingNCT06606418Not applicable
- AI-PROGNOSIS - Digital Biomarkers Development Study (dBM-DEV)Not yet recruitingNCT064447894 countries
- Gut Microbiota in the Progression of Alpha-synucleinopathiesRecruitingNCT053538681 country
- Prodromal Markers in Recurrent Dream Enactment Behaviors Without REM Sleep Without AtoniaRecruitingNCT053538811 country
- Neural Correlates of Impulsivity in Idiopathic REM Sleep Behavior DisorderRecruitingNCT053538551 country
- Progression Follow up of the First-degree Relatives of Patients With REM Sleep Behavior DisorderRecruitingNCT053539591 country
- PREdictive Risk Factors of Conversion Into Idiopathic RBD. Italian StudyRecruitingNCT052625431 country
- Study of the Correlation Between Post-traumatic Stress Disorder and Paradoxical Sleep Behavior DisorderNot yet recruitingNCT062218651 country
- DREAMER - IsolateD REM Sleep Without Atonia as a Risk Factor for REM Sleep Behavior disordERNot yet recruitingNCT06140511
- Prodromal and Overt Parkinson's Disease Epidemiological Study in BrazilRecruitingNCT056775291 country
- Mainz Register of Patients With Sleep DisordersRecruitingNCT053213551 country
- Evolution of RBD in PDCompletedNCT03047408Not applicable1 country
- Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's DiseaseActive, not recruitingNCT066216021 country
- 5-HT RBD REM Sleep Behavior DisorderActive, not recruitingNCT06467461Not applicable1 country
- Predicting Parkinson's Disease Before It Strikes: A Brain Imaging Study in At-Risk IndividualActive, not recruitingNCT077297481 country
- IMPACT 360 for Parkinson's DiseaseActive, not recruitingNCT07443293Phase 21 country