Red-Cell Aplasia, Pure clinical trials
The registry lists 30 studies for Red-Cell Aplasia, Pure across more than 10 countries. 4 are recruiting or about to start. 13 of them are mainly about Red-Cell Aplasia, Pure (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Anemia, Diamond-Blackfan too: 78 studies, 14 open.
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Who runs them
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (6) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Peking Union Medical College Hospital (3) · Fairview University Medical Center (2) · Northwell Health (2) · Bing Han (2) · Novartis Pharmaceuticals (1) · Assistance Publique - Hôpitaux de Paris (1)
What is being tested here
Drugs under test in Red-Cell Aplasia, Pure studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Sirolimus | 1 | 0 | 3 |
| Alemtuzumab | 1 | 0 | 2 |
| Tacrolimus | 0 | 0 | 2 |
| Leucine | 0 | 0 | 1 |
| Peginesatide | 0 | 0 | 1 |
| Rituximab | 0 | 0 | 1 |
| Deferasirox | 0 | 0 | 1 |
| Sotatercept | 0 | 0 | 1 |
| Daclizumab | 0 | 0 | 1 |
| Epoetin Alfa | 0 | 1 | 1 |
Who these studies take
Of the 3 Red-Cell Aplasia, Pure studies recruiting now, 1 (33%) set no upper age limit and 1 (33%) stop at 75 or younger. 3 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (100%) | 3 (100%) |
| 18 | 3 (100%) | 3 (100%) |
| 30 | 2 (67%) | 2 (67%) |
| 40 | 2 (67%) | 2 (67%) |
| 50 | 2 (67%) | 2 (67%) |
| 65 | 2 (67%) | 2 (67%) |
| 75 | 2 (67%) | 2 (67%) |
| 85 | 1 (33%) | 1 (33%) |
Across all 30 studies, recruiting or not: 17% stop at 75 or younger and 13% at 65; 50% take children; 3% are for women only and 0% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 30 of 30. search them.
- Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cellsRecruitingNCT01174108Phase 21 country
- Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling DonorRecruitingNCT03214354Phase 21 country
- National Registry of Rare Kidney DiseasesRecruitingNCT060658521 country
- Efficacy of the antiCD38 Monoclonal Antibody Isatuximab in the Treatment of PCRA by Major ABO Mismatch After Allogeneic Hematopoietic Stem Cell TransplantationNot yet recruitingNCT05559827Phase 2
- Linperlisib in the Treatment of aPRCAWithdrawnNCT07031115Phase 21 country
- Bortezomib Plus Dexamethasone for Acquired Pure Red Cell Aplasia Failure or Relapse After First-line TreatmentCompletedNCT04423367Phase 21 country
- Safety and Efficacy Study of Sotatercept in Adults With Transfusion Dependent Diamond Blackfan AnemiaTerminatedNCT01464164Phase 1/21 country
- Sirolimus Treatment for Newly Diagnosed Primary Acquired PRCACompletedNCT04470804Phase 41 country
- The Use of Trifluoperazine in Transfusion Dependent DBATerminatedNCT03966053Phase 1/21 country
- Pilot Phase I/II Study of Amino Acid Leucine in Treatment of Patients With Transfusion-Dependent Diamond Blackfan AnemiaCompletedNCT01362595Phase 1/21 country
- A Study to Determine Whether Therapy With Daclizumab Will Benefit Patients With Bone Marrow FailureTerminatedNCT00001962Phase 21 country
- Sirolimus Treatment for Refractory PRCACompletedNCT03364764Phase 41 country
- Tacrolimus Treatment for Refractory Autoimmune CytopeniaStatus unknownNCT03918265Phase 41 country
- Efficacy and Safety of Peginesatide (AF37702) in the Treatment of Anemia in Participants With Chronic Kidney DiseaseCompletedNCT00314795Phase 23 countries
- Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan AnemiaCompletedNCT00229619Phase 21 country
- Tacrolimus Treatment for Refractory PRCAStatus unknownNCT03540472Phase 41 country
- A Protocol to Allow Treatment With ICL670 for Patients With or at Risk of Life-threatening Complications of Transfusional Iron Overload Who Are Unable to Tolerate Other Iron Chelators Because of Documented Severe ToxicityCompletedNCT01044186Phase 23 countries
- Pure Red Cell Aplasia in Patients With Chronic Kidney Disease and in Use of Epoetin AlfaStatus unknownNCT02648126Phase 4
- A Study to Observe the Number of Patients Who Develop Pure Red Cell Aplasia (PRCA, a Rare Form of Anemia) While Receiving Epoetin Alfa or Other Recombinant ErythropoietinsCompletedNCT00211029
- Study to Monitor the Incidence of Pure Red Cell Aplasia (PRCA) and/or Antibodies to Erythropoietin Among Participants Receiving Epoetin Alfa or Another ErythropoietinCompletedNCT00210951
- Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure SyndromesCompletedNCT00004143Phase 21 country
- Surveillance Study to Estimate the Incidence of Pure Red Blood Cell Aplasia Among Patients With Chronic Kidney FailureCompletedNCT0039128715 countries
- A Study of Patients Treated With Erythropoietin Receptor Agonists for Anemia Who Developed Anti-erythropoietin AntibodiesWithdrawnNCT00210977
- A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin AlfaCompletedNCT002110687 countries
- A Study of Patients With Pure Red Cell Aplasia Associated With Recombinant Human Erythropoietin TreatmentCompletedNCT002110428 countries
- A Phase III Clinical Trial of PROCRIT (Epoetin Alfa) Versus Placebo in Women Undergoing Adjuvant Chemotherapy for Stage I, II or III Breast CancerTerminatedNCT00246597Phase 3
- Identifying Characteristics of Bone Marrow Failure SyndromesStatus unknownNCT003154191 country
- Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic DisordersCompletedNCT00005893Not applicable1 country
- Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune DiseasesStatus unknownNCT00006055Not applicable1 country
- Stem Cell Transplantation (SCT) for Genetic DiseasesCompletedNCT00004378Not applicable1 country