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Primary hyperoxaluria type 1 clinical trials

The registry lists 22 studies for Primary hyperoxaluria type 1 across more than 10 countries. 8 are recruiting or about to start. 20 of them are mainly about Primary hyperoxaluria type 1 (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-19.

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Status

Completed
8
Recruiting
7
Active, not recruiting
4
Terminated
1
Not yet recruiting
1
No longer available
1

Phase

Phase 2
6
Phase 3
5
Phase 1
4
Early Phase 1
2

Where

United States
12
France
11
Germany
10
United Kingdom
9
Netherlands
7
Israel
6

Who runs them

Dicerna Pharmaceuticals, Inc., a Novo Nordisk company (5) · Alnylam Pharmaceuticals (5) · Hospices Civils de Lyon (2) · YolTech Therapeutics Co., Ltd (2) · RTI International (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Biocodex (1) · Mayo Clinic (1)

What is being tested here

Drugs under test in Primary hyperoxaluria type 1 studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Nedosiran114
Stiripentol111
Lumasiran034

Coming up

2phase 3 studies under way
4studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 4

Who these studies take

Of the 7 Primary hyperoxaluria type 1 studies recruiting now, 5 (71%) set no upper age limit and 1 (14%) stop at 75 or younger. 7 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.

Recruiting studies that take each age, of 7
AgeWomenMen
107 (100%)7 (100%)
187 (100%)7 (100%)
307 (100%)7 (100%)
407 (100%)7 (100%)
507 (100%)7 (100%)
656 (86%)6 (86%)
756 (86%)6 (86%)
856 (86%)6 (86%)

Across all 22 studies, recruiting or not: 27% stop at 75 or younger and 27% at 65; 100% take children; 0% are for women only and 0% for men only; 18% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 22 of 22. search them.