Polycystic Kidney Diseases clinical trials
The registry lists 59 studies for Polycystic Kidney Diseases across more than 10 countries. 12 are recruiting or about to start. 30 of them are mainly about Polycystic Kidney Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03. Counting its narrower condition Polycystic Kidney, Autosomal Dominant too: 218 studies, 50 open.
Get an email when these change. Save the Polycystic Kidney Diseases studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Otsuka Pharmaceutical Development & Commercialization, Inc. (4) · University of Kansas Medical Center (3) · Mario Negri Institute for Pharmacological Research (3) · Mayo Clinic (3) · The Rogosin Institute (2) · University of Cologne (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Asan Medical Center (2)
What is being tested here
Drugs under test in Polycystic Kidney Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tolvaptan | 1 | 2 | 4 |
| Dapagliflozin | 1 | 1 | 1 |
| Sirolimus | 0 | 2 | 4 |
| XL647 | 0 | 0 | 2 |
| Telmisartan | 0 | 2 | 2 |
| Niacinamide | 0 | 0 | 2 |
| Lanreotide | 0 | 2 | 2 |
| R-1,3-Butanediol-based Supplement | 0 | 0 | 1 |
| Pravastatin | 0 | 0 | 1 |
| Sodium Citrate | 0 | 0 | 1 |
Drug classes tested here mTOR inhibitors 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Well-Formulated Ketogenic Diet Polycystic Kidney Disease · Ohio State University
- Feb 2027Metabolic Impacts of Ren-Nu: A Dietary Program for Polycystic Kidney Disease · Richard Fatica
- Aug 2027Study and Management of Cystic Complications in Autosomal Dominant Polycystic Kidney Disease · University Hospital, Brest
Who these studies take
Of the 11 Polycystic Kidney Diseases studies recruiting now, 6 (55%) set no upper age limit and 5 (45%) stop at 75 or younger. 5 (45%) take children under 18. 1 (9%) are for women only and 0 (0%) for men only; 1 (9%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (45%) | 4 (36%) |
| 18 | 11 (100%) | 10 (91%) |
| 30 | 9 (82%) | 8 (73%) |
| 40 | 8 (73%) | 7 (64%) |
| 50 | 8 (73%) | 7 (64%) |
| 65 | 7 (64%) | 6 (55%) |
| 75 | 6 (55%) | 5 (45%) |
| 85 | 6 (55%) | 5 (45%) |
Across all 59 studies, recruiting or not: 47% stop at 75 or younger and 42% at 65; 25% take children; 2% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 59. Browse all 59 → or search them.
- Well-Formulated Ketogenic Diet Polycystic Kidney DiseaseRecruitingNCT06325644Not applicable1 country
- A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)RecruitingNCT04782258Phase 36 countries
- ADPKD Patient RegistryRecruitingNCT040390611 country
- STOP-PKD: SGLT2-inhibition to Improve Prognosis in Polycystic Kidney DiseaseRecruitingNCT07280585Phase 34 countries
- ARPKD Database StudyRecruitingNCT014019981 country
- The German ADPKD Tolvaptan Treatment RegistryRecruitingNCT024975211 country
- Early PKD Observational Cohort StudyRecruitingNCT029367911 country
- Metabolic Impacts of Ren-Nu: A Dietary Program for Polycystic Kidney DiseaseRecruitingNCT07454174Not applicable1 country
- Polycystic Kidney Disease Data RepositoryRecruitingNCT007921551 country
- PKD Clinical and Translational Core StudyRecruitingNCT018732351 country
- The Factors Affecting IPP in Peritoneal Dialysis Patients with Polycystic Kidney DiseaseEnrolling by invitationNCT068412241 country
- Amnioinfusion for Fetal Renal FailureRecruitingNCT06728228Not applicable1 country
- Effects of Exogenous Ketosis on Proteinuria and Renal FunctionCompletedNCT06867471Not applicable1 country
- Probenecid (PB) to Treat Hereditary Nephrogenic Diabetes Insipidus (NDI), ADPKD Treated With Tolvaptan, and Severely Polyuric Patients With Previous Lithium AdministrationCompletedNCT05190744Phase 21 country
- Descriptive Analysis of Preimplantation Genetic Test (PGT)in Couples With Polycystic Kidney Disease (PKD). In the ADPKD Subgroup Evaluation of Outcomes and Complications Comparing Couples in Which the Father is Affected With Couples in Which the Mother is AffectedCompletedNCT073106411 country
- A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less Than 12 Weeks Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)WithdrawnNCT04786574Phase 3
- Treatment of Vascular Stiffness in ADPKDCompletedNCT05228574Phase 41 country
- Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney DiseaseCompletedNCT04284657Phase 21 country
- Artificial Intelligence-based Image Processing Methods to Advance the Characterization of Polycystic Kidney DiseaseActive, not recruitingNCT066889811 country
- KidneYou - Innovative Digital TherapyCompletedNCT05286632Not applicable1 country
- Study and Management of Cystic Complications in Autosomal Dominant Polycystic Kidney DiseaseActive, not recruitingNCT060369921 country
- At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic ConditionsCompletedNCT019316441 country
- Study of the Efficacy and Safety of Tesevatinib in Subjects With ADPKDCompletedNCT03203642Phase 21 country
- Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney DiseaseCompletedNCT02656017Phase 21 country
- A Safety, Pharmacokinetic, Single Ascending Dose Study of Tesevatinib in Pediatric Subjects With Autosomal Recessive Polycystic Kidney Disease (ARPKD)CompletedNCT03096080Phase 11 country
- The Association Between Skeletal Muscle Mass and Severity of Polycystic Liver Disease and Polycystic Kidney DiseaseStatus unknownNCT052159641 country
- Pioglitazone and Lumbar Bone Marrow Fat in Chronic Kidney DiseaseCompletedNCT027397501 country
- Lixivaptan in a Single Subject With Intractable Pain Due to Polycystic Kidney DiseaseNo longer availableNCT037171811 country
- Clinical and Molecular Investigations Into CiliopathiesCompletedNCT000682241 country
- Use of Low Dose Pioglitazone to Treat Autosomal Dominant Polycystic Kidney DiseaseCompletedNCT02697617Phase 21 country
- HALT Progression of Polycystic Kidney Disease Study BCompletedNCT01885559Phase 31 country
- HALT Progression of Polycystic Kidney Disease Study ACompletedNCT00283686Phase 31 country
- Assessing a Dose-Response Relationship of Hydralazine and Its Effects on DNA Methyltransferase 1 in Polycystic Kidney Disease PatientsCompletedNCT03423810Early Phase 11 country
- Outcome of Autosomal Dominant Polycystic Kidney Disease Patients on Peritoneal Dialysis: a National Retrospective Study Based on Two French Registries (the French Language Peritoneal Dialysis Registry and the French Renal Epidemiology and Information Network).CompletedNCT039481131 country
- Evaluation of Nephrectomy Specimen for Intracranial Aneurysm Development in ADPKDCompletedNCT03889392
- Evaluation of Iliac and Renal Artery for Mechanism of Intracranial Aneurysm in ADPKDStatus unknownNCT037264631 country
- Pilot Study of Niacinamide in Polycystic Kidney Disease (NIAC-PKD2)CompletedNCT02558595Phase 21 country
- A Study to Investigate the Long-term Safety and Efficacy of Tolvaptan in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) [Extension of Trial 156-04-251 in Japan]CompletedNCT01280721Phase 31 country
- High Water Intake in Polycystic Kidney DiseaseCompletedNCT02933268Not applicable1 country
- Pulsed Oral Sirolimus in Autosomal Dominant Polycystic Kidney DiseaseStatus unknownNCT02055079Phase 31 country
- 8-Week Study of Tolvaptan Dose Forms in Autosomal Dominant Polycystic Kidney Disease (ADPKD)CompletedNCT01451827Phase 21 country
- Research Into the Molecular Bases of a New Phenotype Combining Premature White Hair, Polycystic Kidney Disease, Aortic Dilation/Dissection and LymphopeniaCompletedNCT036513881 country
- Dose-finding Study of New Tolvaptan Formulation in Subjects With ADPKDCompletedNCT01210560Phase 21 country
- Somatostatin In Patients With Autosomal Dominant Polycystic Kidney Disease And Moderate To Severe Renal InsufficiencyCompletedNCT01377246Phase 31 country
- Autosomal Dominant Polycystic Kidney Disease (ADPKD) Pain StudyCompletedNCT00571909Not applicable1 country
- Study of Lanreotide to Treat Polycystic Kidney DiseaseStatus unknownNCT01616927Phase 31 country
- Repository Study of Autosomal Dominant Polycystic Kidney DiseaseWithdrawnNCT019880381 country
- Uncontrolled, Open Label, Pilot and Feasibility Study of Niacinamide in Polycystic Kidney DiseaseCompletedNCT02140814Phase 21 country
- High Water Intake to Slow Progression of Polycystic Kidney DiseaseCompletedNCT00784030Not applicable1 country
- Mesenchymal Stem Cells Transplantation in Patients With Chronic Renal Failure Due to Polycystic Kidney DiseaseCompletedNCT02166489Phase 11 country