Pancreatitis, Acute Necrotizing clinical trials
The registry lists 74 studies for Pancreatitis, Acute Necrotizing across more than 10 countries. 19 are recruiting or about to start. 63 of them are mainly about Pancreatitis, Acute Necrotizing (how this is decided). Per ClinicalTrials.gov, last updated 2026-07-10.
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Who runs them
Asian Institute of Gastroenterology, India (4) · AdventHealth (4) · Orlando Health, Inc. (3) · Nantes University Hospital (3) · Chinese University of Hong Kong (2) · Tokyo University (2) · Moscow Regional Research and Clinical Institute (MONIKI) (2) · First People's Hospital of Hangzhou (2)
What is being tested here
Drugs under test in Pancreatitis, Acute Necrotizing studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Pancreatic Enzyme | 1 | 1 | 1 |
| Meropenem | 0 | 0 | 2 |
| Thymalfasin | 0 | 0 | 1 |
| Pentoxifylline | 0 | 0 | 1 |
| Streptokinase | 0 | 1 | 1 |
| Fluorouracil | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7, phase 3 first
- Apr 2027PERT in Acute Necrotizing Pancreatitis · Phase 3 · Asian Institute of Gastroenterology, India
- Jun 2027Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis · Phase 3 · Asian Institute of Gastroenterology, India
- Dec 2026Integrating Plasma Metagenomics and Host Response for Accurate Diagnosis of Infected Pancreatic Necrosis in a Prospective Multicenter Cohort of Acute Necrotizing Pancreatitis · Xiangya Hospital of Central South University
- Dec 2026Endoscopic Pancreatic Duct Stent Placement Versus Conventional Approach in the Treatment of Early Phase Acute Pancreatitis · Almazov National Medical Research Centre
- Dec 2026Organ Dysfunction Changes in Acute Necrotizing Pancreatitis Patients With Sepsis Following Open Necrosectomy · West China Hospital
- Dec 2026Organ Dysfunction Change in Acute Necrotizing Pancreatitis Patients With Sepsis After Open Necrosectomy · Chunling Jiang
- Feb 2027A Study to Evaluate Splenectomy on Debridement for Acute Necrotizing Pancreatitis With Pancreatic Sinistral Portal Hypertension · Zhejiang University
Who these studies take
Of the 12 Pancreatitis, Acute Necrotizing studies recruiting now, 9 (75%) set no upper age limit and 3 (25%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 12 (100%) | 12 (100%) |
| 30 | 12 (100%) | 12 (100%) |
| 40 | 12 (100%) | 12 (100%) |
| 50 | 12 (100%) | 12 (100%) |
| 65 | 11 (92%) | 11 (92%) |
| 75 | 10 (83%) | 10 (83%) |
| 85 | 9 (75%) | 9 (75%) |
Across all 74 studies, recruiting or not: 23% stop at 75 or younger and 8% at 65; 11% take children; 0% are for women only and 1% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Pancreatitis, Acute Necrotizing studies take
Of 20 interventional studies with no phase under Pancreatitis, Acute Necrotizing, half reached primary completion within 29 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 29 mo22–36 · 20 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 74. Browse all 74 → or search them.
- Organ Dysfunction Change in Acute Necrotizing Pancreatitis Patients With Sepsis After Open NecrosectomyRecruitingNCT063808421 country
- Registry of Patients Undergoing Endoscopic Management of Pancreatic Fluid CollectionsRecruitingNCT061794591 country
- Necrosectomy With Cryotechnology for Accelerated RemovalRecruitingNCT06553651Not applicable1 country
- Pancreatic Enzyme Replacement in Acute Necrotizing PancreatitisRecruitingNCT07441824Phase 31 country
- Strategic Timing of Endoscopic Interventions in Infected Necrotizing PancreatitisRecruitingNCT07406698Not applicable1 country
- Effectiveness of Endorotor PED® System Versus Conventional Endoscopic Techniques for the Management of Walled-off Pancreatic Necrosis in Acute Necrotizing Pancreatitis: Randomized Single-blinded Controlled Superiority Trial and Cost-utility AnalysisRecruitingNCT07253350Not applicable1 country
- Integrating Plasma Metagenomics and Host Response for Accurate Diagnosis of Infected Pancreatic Necrosis in a Prospective Multicenter Cohort of Acute Necrotizing PancreatitisNot yet recruitingNCT07308600
- PERT in Acute Necrotizing PancreatitisNot yet recruitingNCT07211568Phase 3
- Organ Dysfunction Changes in Acute Necrotizing Pancreatitis Patients With Sepsis Following Open NecrosectomyNot yet recruitingNCT072012461 country
- Encapsulation-oriented vs. Timing-oriented Strategies for Necrotizing PancreatitisNot yet recruitingNCT07106346Not applicable1 country
- Endoscopic Pancreatic Duct Stent Placement Versus Conventional Approach in the Treatment of Early Phase Acute PancreatitisNot yet recruitingNCT07093996Not applicable2 countries
- A Study to Evaluate Splenectomy on Debridement for Acute Necrotizing Pancreatitis With Pancreatic Sinistral Portal HypertensionRecruitingNCT07080697Not applicable1 country
- The Role of Double Pigtail Plastic Stents During Endoscopic Transmural Drainage of Pancreatic Fluid Collections.Not yet recruitingNCT06134024Not applicable
- Fasciotens to Treat an Open Abdomen - a Prospective Cohort StudyRecruitingNCT04033614Not applicable1 country
- Tracking ENcapsulation of Pancreatic Collections in Acute Necrotizing PancreatitisRecruitingNCT057166331 country
- Immediate Necrosectomy vs. Step-up Approach for Walled-off NecrosisRecruitingNCT05451901Not applicable1 country
- Timing of Necrosectomy After Endoscopic Drainage of Walled-off Pancreatic Necrosis (WON)RecruitingNCT05252897Not applicable6 countries
- Timing of Transmural Stent Removal in Necrotizing PancreatitisNot yet recruitingNCT04963868Not applicable1 country
- Dual-scopic Pancreatic Necrosectomy (DPN)RecruitingNCT04443595Not applicable1 country
- PancRea: Risk Factors and Outcomes of Infected Pancreatic NecrosisCompletedNCT032538611 country
- Surgical vs Endoscopic Resection of Walled Off Pancreatic Necrosis Using the Powered Endoscopic Debridement SystemWithdrawnNCT06691919Not applicable
- Immediate vs. On-demand Endoscopic Necrosectomy in Infected Walled-off Pancreatic NecrosisCompletedNCT05530772Not applicable1 country
- CMV Reactivation in Acute Necrotizing PancreatitisCompletedNCT058980481 country
- Etiology, Clinical Picture, Complications and Outcomes of Necrotizing Pancreatitis in Children.CompletedNCT067003301 country
- The Study of the Natural Way of Development of External Pancreatic Fistulas in Children with Necrotizing PancreatitisCompletedNCT067064401 country
- Endoscopic Step-up Approach vs Aggressive Debridement of Large Pancreatic Walled-off NecrosisCompletedNCT05601687Not applicable1 country
- coMpliAnce With evideNce-based cliniCal Guidelines in the managemenT of Acute biliaRy pancreAtitisCompletedNCT047479902 countries
- Acute Pancreatitis and Thrombosis (PATHRO)CompletedNCT046427941 country
- Hot AXIOS® Prosthesis in Real Life Conditions -CompletedNCT047824141 country
- Open Surgery for Necrotizing PancreatitisCompletedNCT046735521 country
- A Retrospective Analysis of Pancreatic Injuries and Treatment OutcomesCompletedNCT062278711 country
- ABTHERA ADVANCE™ Use Without Wittman PatchCompletedNCT049869431 country
- Randomized Trial of Immediate Endoscopic Necrosectomy vs. Step-up Endoscopic Interventions in Necrotizing PancreatitisActive, not recruitingNCT05043415Not applicable1 country
- Endoscopic Necrosectomy Versus Step-up Endoscopic InterventionCompletedNCT04113499Not applicable1 country
- Imaging Modalities for Pancreatic CollectionsTerminatedNCT035565011 country
- Lumen-apposing Metal Stent With or Without Coaxial Plastic Stent for Treatment of Walled-off Pancreatic NecrosisCompletedNCT03923686Not applicable1 country
- Percutaneous Continuous Irrigation Combined With Transgastric Necrosectomy usingLAMS in Treatment of SAPCompletedNCT055088281 country
- Lumen Apposing Metal Stents vs Double Pigtail StentsCompletedNCT04057846Not applicable1 country
- Acute Necrotizing Pancreatitis and Infected Pancreatic NecrosisCompletedNCT032341661 country
- Molecular Analysis of Microbial DNA in Infected Necrotizing PancreatitisCompletedNCT018154891 country
- Pancreatic Duct Stent for Acute Necrotizing PancreatitisCompletedNCT03115918Not applicable1 country
- EUS Shear Wave for Solid Pancreatic Lesions.Status unknownNCT050958311 country
- AXIOS Lumen Apposing Metal Stent for Walled Off Necrosis Drainage IDE StudyCompletedNCT03525808Not applicable1 country
- EUS-guided Transmural Drainage of Walled-off Pancreatic Necrosis: Plastic vs Metallic Protesis.CompletedNCT03100578Not applicable1 country
- EndoRotor DEN (Direct Endoscopic Necrosectomy)TrialCompletedNCT03694210Not applicable3 countries
- The Efficacy of Pancreatic Duct Stenting With Rectal Indomethacin in Preventing Post-ERCP PancreatitisCompletedNCT03643900Not applicable1 country
- Impact of Transmural Plastic Stent on Recurrence of Pancreatic Fluid Collection After Metal Stent Removal in Disconnected Pancreatic DuctCompletedNCT03436043Not applicable1 country
- Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing PancreatitisCompletedNCT02473406Phase 41 country
- Risk Factors for ARDS in Patients With Acute Necrotizing PancreatitisCompletedNCT02641964
- Plastic Stents vs. NAGI Bi-flanged Metal Stent for Endoscopic Ultrasound Guided Drainage of Walled-off NecrosisStatus unknownNCT04479228Not applicable