Oropharyngeal Neoplasms: all 378 studies

Page 2 of 4. Open to participants first (99), then studies with results posted, then the rest; newest registration first within each.

• Changes to Function and Quality of Life and Patient Experience for Patients Undergoing Treatments for Recurrent Oropharyngeal CancerCompletedNCT04952922Results posted
• HYHOPE: De-intensified Hypofractionated Radiation Therapy for HPV-associated Oropharynx CancerCompletedNCT04580446Phase 1Results posted
• Testing the Addition of an Anti-cancer Drug, BAY 1895344, With Radiation Therapy to the Usual Pembrolizumab Treatment for Recurrent Head and Neck CancerActive, not recruitingNCT04576091Phase 1Results posted
• Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With CisplatinCompletedNCT04541355Phase 2Results posted
• HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated CancersCompletedNCT04432597Phase 1/2Results posted
• Combination Immunotherapy in Subjects With Advanced HPV Associated MalignanciesCompletedNCT04287868Phase 1/2Results posted
• Celecoxib Through Surgery and Radiation Therapy for the Treatment of Advanced Head and Neck CancerTerminatedNCT04162873Phase 2Results posted
• Physiological Flow of Liquids in Head and Neck Cancer Patients: A Pilot StudyCompletedNCT04112940Results posted
• E7 TCR Cell Induction Immunotherapy for Stage II and Stage III HPV-Associated Oropharyngeal CancerTerminatedNCT04015336Phase 2Results posted
• De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal CancerActive, not recruitingNCT03952585Phase 2/3Results posted
• De-Escalation Radiotherapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell CarcinomaActive, not recruitingNCT03822897Phase 2Results posted
• Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell CarcinomaTerminatedNCT03799445Phase 2Results posted
• Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx CancerCompletedNCT03715946Phase 2Results posted
• TraceIT Tissue Marker to Mark the Primary Resection Bed Margins of Oropharyngeal CancersTerminatedNCT03713021Not applicableResults posted
• Use of a Proliferation Saturation Index to Determine Personalized Radiotherapy for HPV + Oropharyngeal CancersCompletedNCT03656133Not applicableResults posted
• M7824 in Subjects With HPV Associated MalignanciesCompletedNCT03427411Phase 2Results posted
• Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell CarcinomaCompletedNCT03422536Phase 2Results posted
• Individualized Adaptive De-escalated Radiotherapy for HPV-related Oropharynx CancerCompletedNCT03416153Phase 2Results posted
• Gabapentin for the Reduction of Radiation Therapy Induced Pain During the Treatment of Oropharyngeal CancerCompletedNCT03269344Phase 3Results posted
• Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take CisplatinCompletedNCT03258554Phase 2/3Results posted
• Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal CancerTerminatedNCT03258008Phase 2Results posted
• Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell CarcinomaActive, not recruitingNCT03174275Phase 2Results posted
• Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell CarcinomaCompletedNCT03082534Phase 2Results posted
• P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCCCompletedNCT03077243Phase 2Results posted
• Prospective, Multicenter da Vinci® SP™ Surgical System TORS StudyCompletedNCT03049280Not applicableResults posted
• ACTOplus Met XR in Treating Patients With Stage I-IV Oral Cavity or Oropharynx Cancer Undergoing Definitive TreatmentTerminatedNCT02917629Phase 2Results posted
• Evaluation of De-escalated Adjuvant Radiation Therapy for Human Papillomavirus (HPV)-Associated Oropharynx CancerCompletedNCT02908477Phase 3Results posted
• Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck CancerCompletedNCT02589938Not applicableResults posted
• Pembrolizumab in Combination With CRT for LA-SCCHNCompletedNCT02586207Phase 1Results posted
• HPV Vaccination: An Investigation of Physician Reminders and Recommendation ScriptsCompletedNCT02551887Not applicableResults posted
• De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up StudyCompletedNCT02281955Phase 2Results posted
• T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated CancersCompletedNCT02280811Phase 1/2Results posted
• A Pilot Study at a Single-Institution of Pregabalin in the Management of Mucositis Pain in Patients Undergoing Chemoradiation Therapy to the Head and Neck.CompletedNCT02277548Not applicableResults posted
• Nab-paclitaxel and Carboplatin Followed by Response-Based Local Therapy in Treating Patients With Stage III or IV HPV-Related Oropharyngeal CancerCompletedNCT02258659Phase 2Results posted
• Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck CancerTerminatedNCT02177838Not applicableResults posted
• A Single-arm Phase II Study of Post-Transoral Robotic Surgery (TORS) Alone to the Primary Tumor Site and Selective Neck Dissection (SND) Followed by Adjuvant Radiation Therapy (+/- Chemotherapy) to the Regional Nodes for Advanced Stage, Human Papilloma Virus (HPV) Positive, Oropharyngeal CancerCompletedNCT02159703Phase 2Results posted
• Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation TherapyCompletedNCT02123511Phase 2Results posted
• Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal CancerActive, not recruitingNCT01898494Phase 2Results posted
• Acupuncture in Reducing the Severity of Chemoradiation-induced Mucositis in Patients With Oropharyngeal CancerTerminatedNCT01883908Not applicableResults posted
• PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck CancerCompletedNCT01816984Phase 1/2Results posted
• 18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis TherapyCompletedNCT01806675Phase 1/2Results posted
• Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck CancerCompletedNCT01711541Phase 1/2Results posted
• Post Operative Adjuvant Therapy De-intensification Trial for Human Papillomavirus-related, p16+ Oropharynx CancerTerminatedNCT01687413Phase 3Results posted
• Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck Cancer Who Are Receiving Cisplatin and Radiation TherapyTerminatedNCT01682031Phase 2Results posted
• Reduced-intensity Therapy for Oropharyngeal Cancer in Non-smoking HPV-16 Positive PatientsCompletedNCT01663259Not applicableResults posted
• Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated CancersCompletedNCT01585428Phase 2Results posted
• De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell CaCompletedNCT01530997Phase 2Results posted
• Study of Chemotherapy Prior to Radiotherapy and Chemotherapy in Patients With HPV Associated Cancer of the Oral CavityTerminatedNCT01525927Phase 2Results posted
• Erlotinib Hydrochloride and Radiation Therapy in Stage III-IV Squamous Cell Cancer of the Head and NeckTerminatedNCT01192815Phase 2Results posted
• Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study.CompletedNCT01173692Phase 2Results posted
• Capecitabine and Lapatinib Ditosylate in Treating Patients With Squamous Cell Cancer of the Head and NeckCompletedNCT01044433Phase 2Results posted
• Respiratory-Swallow Training in Veterans With Oropharyngeal CancerCompletedNCT01032928Phase 2Results posted
• Fosaprepitant Dimeglumine, Palonosetron Hydrochloride, and Dexamethasone in Preventing Nausea and Vomiting Caused by Cisplatin in Patients With Stage III or Stage IV Head and Neck Cancer Undergoing Chemotherapy and Radiation TherapyTerminatedNCT00895245Phase 2Results posted
• F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer PatientsCompletedNCT00721799Phase 2Results posted
• OraTest in Combination With Visual Examination and Visual Examination AloneTerminatedNCT00537199Phase 3Results posted
• Saracatinib in Treating Patients With Recurrent or Metastatic Head and Neck CancerCompletedNCT00513435Phase 2Results posted
• Dasatinib in Treating Patients With Recurrent or Metastatic Head and Neck CancerCompletedNCT00507767Phase 2Results posted
• Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck CancerCompletedNCT00492089Phase 2Results posted
• A Pilot Trial of Image-Guided Adaptive Radiotherapy for Head and Neck CancerCompletedNCT00490282Not applicableResults posted
• Robotic Assisted Surgery in Upper Aerodigestive Tract SurgeryCompletedNCT00473564Not applicableResults posted
• Cisplatin and Radiation Therapy With or Without Erlotinib Hydrochloride in Treating Patients With Stage III or Stage IV Head and Neck CancerCompletedNCT00410826Phase 2Results posted
• Sunitinib in Treating Patients With Recurrent and/or Metastatic Head and Neck CancerCompletedNCT00387335Phase 2Results posted
• Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral LeukoplakiaCompletedNCT00330382Phase 2Results posted
• Bortezomib With or Without Irinotecan in Treating Patients With Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Head and NeckCompletedNCT00103259Phase 2Results posted
• SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck CancerCompletedNCT00095628Phase 2Results posted
• Oral Mucositis Management in Patients Receiving Radiation for Head and Neck Cancer: An Evaluation of a Barrier Based TreatmentActive, not recruitingNCT07697287Phase 4
• Tumor Mutational Burden, Liquid Biopsy, Angiogenic Factors and DCE-MRI Perfusion in HPV-Negative Oropharyngeal CancerActive, not recruitingNCT07407205Not applicable
• Speech-based AI-driven Diagnostics and Rehabilitation for Oral and Oropharyngeal Cancer.CompletedNCT07347899
• Collagen Matrix in Oral Cancer SurgeryCompletedNCT07337122
• Predictive Tools in Head and Neck Cancer Patients Undergoing RadiotherapyActive, not recruitingNCT06806683
• Thermotherapy for Locally Advanced Head and Neck CancerActive, not recruitingNCT06761937Phase 1
• Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal CancerCompletedNCT06701058
• Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples?Active, not recruitingNCT06592716
• INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCCActive, not recruitingNCT06295731Phase 2/3
• Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported XerostomiaWithdrawnNCT06276946Not applicable
• Trial of Individualized Adaptive RT in HPV-related High Risk Oropharynx CancerActive, not recruitingNCT06234748Phase 2
• Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)Active, not recruitingNCT06167291Phase 2
• Circulating Biomarkers in Oropharyngeal CancersActive, not recruitingNCT05904327
• Liposomal Bupivacaine and Transoral Robotic SurgeryCompletedNCT05862792
• Feasibility of Adaptive Radiation Therapy for Human-papilloma Virus-positive Oropharyngeal Cancer Patients on MRIdian LinacWithdrawnNCT05849142Not applicable
• A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC)Active, not recruitingNCT05814549
• The ENHANCE Study: Exercise and Nutrition in Head And Neck CancEr SurvivorsCompletedNCT05798780Not applicable
• Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)Active, not recruitingNCT05787639Phase 2
• Two-cohort Study of Niraparib and Dostarlimab Plus (Chemo)RadIotherapy in Locally-Advanced Head and Neck Squamous Cell CarcinomaActive, not recruitingNCT05784012Phase 1/2
• Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and NeckActive, not recruitingNCT05721755Phase 3
• Outpatient Ultrasound for the Diagnostic Work-up of Oropharynx CancerCompletedNCT05698667Not applicable
• Surgeon-performed Outpatient Transoral and Transcervical Ultrasound of the OropharynxCompletedNCT05696314Not applicable
• Phase 2 Study of Neoadjuvant SAR444245 Plus Cemiplimab in HPV Related Oropharynx Squamous Cell CarcinomaWithdrawnNCT05535023Phase 2
• A Pneumatic Compression Device for the Treatment of Lymphedema in Patients With Stage II-IV Head and Neck Cancer After ChemoradiationWithdrawnNCT05512767Not applicable
• Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)CompletedNCT05461430
• Investigating the Association Between Microbiota and Esophageal/Oropharyngeal CancerStatus unknownNCT05412628Not applicable
• Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal CancerActive, not recruitingNCT05387915Phase 2
• Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and EsophagitisCompletedNCT05369234Phase 3
• Staying Connected: a Mobile Health Study With the Noona® and Mobili-T® SystemsCompletedNCT05368025
• BALSTILIMAB on Viral Clearance in HPV+ Oropharyngeal Cancer PatientsWithdrawnNCT05363709Phase 2
• Safety and Efficacy of APG-157 in Head and Neck CancerActive, not recruitingNCT05312710Phase 2
• Usefulness of Integrated PET/MRI in Oropharyngeal Squamous Cell Carcinoma EvaluationCompletedNCT05299957
• Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT StudyActive, not recruitingNCT05075980Phase 2
• Single Modality Trans Oral Robotic Surgery for Primary Oropharyngeal Cancer: Exploring the Impact of Surgical Margins on Local Disease RecurrenceStatus unknownNCT05065086
• Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck CancersActive, not recruitingNCT05063552Phase 2/3

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