An observational study in Obesity Hypoventilation Syndrome, sponsored by Wissenschaftliches Institut Bethanien e.V. Recruiting at 1 site in Germany. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2023-12-15.
Sponsored by Wissenschaftliches Institut Bethanien e.V · Observational
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Using an extensive set of both volitional and non-volitional tests of respiratory muscle function and strength it is the aim of this study to
73 studies on the registry are indexed under Obesity Hypoventilation Syndrome; 10 are open to participants now.
This study's planned enrollment of 50 is close to the median of 50 across 25 observational studies indexed under Obesity Hypoventilation Syndrome.
Browse Obesity Hypoventilation Syndrome studies →Wissenschaftliches Institut Bethanien e.V is the lead sponsor of 25 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with OHS or OHS-risk
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
stage 0: OHS-risk (OSA / no hypercapnia) stage I: obesity associated hypoventilation (intermittent hypercapnia during sleep, arterial carbon dioxide partial pressure (PaCO2) or transcutaneous carbon dioxide partial pressure (PtcCO2) morning \~ evening), bicarbonate \< 27 mmol/L awake) stage II: obesity associated hypoventilation (intermittent hypercapnia during sleep, PaCO2 or PtcCO2 morning \> evening, bicarbonate ≥ 27 mmol/L awake) stage III: OHS (hypercapnia, carbon dioxide partial pressure (PCO2) \> 45 mmHg awake) stage IV: OHS with end organ damage (hypercapnia , PCO2 \> 45 mmHg awake, cardiometabolic comorbidities) diagnostic tests: magnetic phrenic nerve stimulation, diaphragmatic ultrasound
Diagnostic Test: magnetic phrenic nerve stimulation
cervical and cortical stimulation of N. Vagus
Also known as: diaphragmatic ultrasound, spirometry, Sleep-studies, capnography
Carbon dioxide rebreathing test
minute volumen (L/min)
Time frame: 1 day
transdiaphragmatic pressure (non-volitional)
difference between intraesophageal and intragastral pressure after posterior magnetic stimulation of the phrenic nerves
Time frame: 1 day
peripheral nervous system (non-volitional)
electroneurography after posterior magnetic stimulation of the phrenic nerves
Time frame: 1 day
diaphragmal ultrasound - excursion (non-volitional)
excursion of the diaphragm
Time frame: 1 day
diaphragmal ultrasound - thickness (non-volitional)
thickness of the diaphragm
Time frame: 1 day
P0.1 (volitional)
mouth occlusion pressure (kPa)
Time frame: 1 day
PImax (volitional)
maximal inspiratory mouth pressure (kPa)
Time frame: 1 day
Comparison of PImax and transdiaphragmatic pressure
Correlation between PImax and transdiaphragmatic pressure
Time frame: 1 day
Plan to share: No
No publications or documents are linked to this record.
Started May 2019 (actual). Primary completion is estimated for Dec 2024, 67 months after the start.
How these figures are worked out, and which studies are left out of them.
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Obesity Hypoventilation Syndrome →
Wissenschaftliches Institut Bethanien e.V