Neurofibromatoses: all 188 studies

Page 1 of 2. Open to participants first (24), then studies with results posted, then the rest; newest registration first within each.

• Neurocutaneous Syndromes in Children: Prevalence and Clinical CharacteristicsNot yet recruitingNCT07843823
• How Can the Experience of Hospital Outpatient Departments be Improved?Not yet recruitingNCT07818213
• Mirdametinib in Patients With Advanced NF1-mutant MelanomaRecruitingNCT07237100Phase 2
• Tailoring an Online Platform to Promote Evidence-Based Care for Adults With Neurofibromatosis 1 and Low Health LiteracyRecruitingNCT07233408Not applicable
• Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1RecruitingNCT07102394Phase 1
• Clinical and Demographic Characteristics of Adult p Atients With NEurofibromatosis in RUSsiaRecruitingNCT07088991
• Follow-up Study to Evaluate the Safety and Efficacy of FCN-159 in Pediatric Participants With Neurofibromatosis Type 1Not yet recruitingNCT07024394Phase 1/2
• PAS-004 in Adults Who Have Neurofibromatosis Type 1 With Plexiform NeurofibromasRecruitingNCT06961565Phase 1
• Low-dose Selumetinib for the Treatment of Plexiform Neurofibromas in Chinese ChildrenNot yet recruitingNCT06763315Phase 2
• The Clinical Study of the Treatment of Patients With Type I Neurofibromatosis With Smetinib Hydrosulfate CapsuleNot yet recruitingNCT06621082Phase 2
• Genetic Bases of Neuroendocrine Neoplasms in Mexican PatientsRecruitingNCT06523582
• A Retrospective Study on Epidemiological Characteristics of Chinese NF1 Patients in Real World (PROMISE)RecruitingNCT06379230
• Development of Non-Invasive Prenatal Diagnosis for Single Gene DisordersRecruitingNCT06147414
• 89Zr-Bevacizumab PET/CT Imaging in NF2 PatientsRecruitingNCT05685836
• Glioma Developmental and HyperActive Ras Tumor (DHART) BoardRecruitingNCT05489783
• HL-085 in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform NeurofibromasRecruitingNCT05331105Phase 2
• Evaluation of Percutaneous Cryotherapy in the Treatment of Plexiform Neurofibromas and Unresectable Neurofibromas in Neurofibromatosis Type 1RecruitingNCT05199376Not applicable
• Reliability of Functional Outcome Measures in Neurofibromatosis 1: Test- RetestRecruitingNCT05186870
• Individual Patient Compassionate Use of MirdametinibAvailableNCT05028166
• Vestibular Precision: Physiology & PathophysiologyEnrolling by invitationNCT04890132Not applicable
• GROWing Up With Rare GENEtic SyndromesRecruitingNCT04463316
• The Neurofibromatosis-associated Tumor BiobankNot yet recruitingNCT03359304
• The NF Registry Sponsored by the Children's Tumor FoundationRecruitingNCT01885767
• Natural History Study of Patients With Neurofibromatosis Type 2RecruitingNCT00598351
• Evaluating Mitochondrial Dysfunction in Patients With Neurofibromatosis Type 1CompletedNCT05912400Results posted
• HIFU Treatment of Cutaneous Neurofibromas in Neurofibromatosis Type 1: Safety and EfficacyCompletedNCT05119582Not applicableResults posted
• Innovation in the Treatment of Persistent Pain in Adults With NF1: Implementation of the iCanCope Mobile Application- Clinical TrialCompletedNCT04561765Not applicableResults posted
• NFX-179 Topical Gel Treatment in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF)CompletedNCT04435665Phase 2Results posted
• MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform NeurofibromasActive, not recruitingNCT03962543Phase 2Results posted
• Medication Adherence in Children, Adolescents and Adults With Neurofibromatosis Type 1(NF1) on Clinical Treatment TrialsCompletedNCT03531814Not applicableResults posted
• Dexmedetomidine and Propofol for Pediatric MRI SedationCompletedNCT03513757Phase 4Results posted
• Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform NeurofibromasCompletedNCT03231306Phase 2Results posted
• Trial of Selumetinib in Patients With Neurofibromatosis Type II Related TumorsTerminatedNCT03095248Phase 2Results posted
• Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous NeurofibromaCompletedNCT02839720Phase 2Results posted
• AZD2014 In NF2 Patients With Progressive or Symptomatic MeningiomasCompletedNCT02831257Phase 2Results posted
• A Study of INFUSE Bone Graft (BMP-2) in the Treatment of Tibial Pseudarthrosis in Neurofibromatosis Type 1 (NF1)TerminatedNCT02718131Not applicableResults posted
• Acceptance and Commitment Training for Adolescents and Young Adults With Neurofibromatosis Type 1, Plexiform Neurofibromas, and Chronic PainCompletedNCT02471339Phase 3Results posted
• Feasibility and Clinically Application of Magnetic Resonance FingerprintingTerminatedNCT02387840Not applicableResults posted
• Everolimus for Treatment of Disfiguring Cutaneous Lesions in Neurofibromatosis1 CRAD001CUS232TCompletedNCT02332902Phase 2Results posted
• Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular SchwannomasCompletedNCT02129647Phase 2Results posted
• Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 MutationsCompletedNCT02124772Phase 1/2Results posted
• Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 in Children and AdultsCompletedNCT02101736Phase 2Results posted
• MEK Inhibitor PD-0325901 Trial in Adolescents and Adults With NF1CompletedNCT02096471Phase 2Results posted
• Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular SchwannomasCompletedNCT01767792Phase 2Results posted
• Phase I Photodynamic Therapy (PDT) for Benign Dermal Neurofibromas (NF1)CompletedNCT01682811Phase 1Results posted
• Phase II Study of Gleevec/Imatinib Mesylate (STI-571, NCS 716051) in Neurofibromatosis (NF1) Patients With Plexiform NeurofibromasCompletedNCT01673009Phase 2Results posted
• Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway GliomaCompletedNCT01553149Phase 2Results posted
• Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2CompletedNCT01419639Phase 2Results posted
• Study of Sutent®/Sunitinib (SU11248) in Subjects With NF-1 Plexiform NeurofibromasTerminatedNCT01402817Phase 2Results posted
• Efficacy and Safety of RAD001 in Treating Plexiform Neurofibromas (PN) Associated With Neurofibromatosis (NF1)TerminatedNCT01365468Phase 2Results posted
• Sorafenib in Children and Young Adults With Recurrent or Progressive Low-Grade AstrocytomasTerminatedNCT01338857Phase 2Results posted
• Study of Tasigna®/Nilotinib (AMN107) in Neurofibromatosis (NF1) Patients With Plexiform NeurofibromasCompletedNCT01275586Early Phase 1Results posted
• Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2)CompletedNCT01207687Phase 2Results posted
• Pilot Study of Gleevec/Imatinib Mesylate (STI-571, NSC 716051) in Neurofibromatosis (NF1) Patient With Plexiform NeurofibromasCompletedNCT01140360Phase 1/2Results posted
• Bevacizumab in Treating Patients With Recurrent or Progressive MeningiomasCompletedNCT01125046Phase 2Results posted
• Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related TumorsCompletedNCT00973739Phase 2Results posted
• Concentration and Activity of Lapatinib in Vestibular SchwannomasCompletedNCT00863122Early Phase 1Results posted
• A Randomized Placebo-Controlled Study of Lovastatin in Children With Neurofibromatosis Type 1CompletedNCT00853580Phase 2Results posted
• Medical Treatment of "High-Risk" NeurofibromasCompletedNCT00846430Phase 2Results posted
• A Phase II Study of the mTOR Inhibitor Sirolimus in Neurofibromatosis Type 1 Related Plexiform NeurofibromasCompletedNCT00634270Phase 2Results posted
• Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable MeningiomaCompletedNCT00589784Phase 2Results posted
• Study of PEG-Intron for Plexiform NeurofibromasCompletedNCT00396019Phase 2Results posted
• AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the SpineTerminatedNCT00326872Phase 2Results posted
• Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath TumorsCompletedNCT00304083Phase 2Results posted
• Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform NeurofibromasCompletedNCT00076102Phase 2Results posted
• Fludeoxyglucose F 18 Positron Emission Tomography and Magnetic Resonance Perfusion Imaging in Patients With Neurofibromatosis 1 and Plexiform NeurofibromaTerminatedNCT00060008Not applicableResults posted
• Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform NeurofibromasCompletedNCT00030264Phase 2Results posted
• R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform NeurofibromasCompletedNCT00021541Phase 2Results posted
• Assessing the Efficacy of Repeat, Monthly Treatments of Alexandrite Laser for NF1-associated Cutaneous Neurofibromas (cNFs)SuspendedNCT06934928Not applicable
• A Decentralized Clinical Trial to Promote Evidence-Based Care for Underserved Patients With Neurofibromatosis 1CompletedNCT06262113Not applicable
• Dosing and Tolerability of Deoxycholic Acid Vs. Polidocanol in the Treatment of Neurofibromatosis Type 1 Cutaneous NeurofibromasCompletedNCT06120036Phase 1
• FCN-159 in Adult Patients With Symptomatic, Inoperable Neurofibromatosis Type 1-Related Plexiform NeurofibromasActive, not recruitingNCT05913037Phase 3
• Selumetinib in Chinese Paediatric With Post-operative NF1-PNs, PhaseⅡ, Double-Blinded, Placebo-Controlled StudyWithdrawnNCT05825365Phase 2
• Mindful Parenting - A Single Case Experimental Design StudyStatus unknownNCT05779527Not applicable
• US Selumetinib RegistryTerminatedNCT05683678
• Natural History Study of Cutaneous Neurofibromas in People With NF1Active, not recruitingNCT05581511
• DPCP to Treat Cutaneous Neurofibromas Associated With NF1CompletedNCT05438290Phase 1
• Intervention Effectiveness on the Neurocognitive Functioning of Children and Adolescents With Neurofibromatosis Type 1CompletedNCT05377008Not applicable
• Clinical Hypnosis and Home Blood Pressure Monitoring in Children With Neurofibromatosis Type 1CompletedNCT05196854Not applicable
• Molecular Aspects of Preimplantation Genetic Diagnosis for NF1CompletedNCT05149469
• A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of TQ-B3234 in Patients With Type I NeurofibromatosisStatus unknownNCT05107037Phase 1
• A Clinical Trial to Evaluate the Safety and Efficacy of AL2846 Capsules in Chinese Patients With Type I NeurofibromatosisTerminatedNCT05011019Phase 1/2
• Mechanism of Action of Transcranial Direct Current Stimulation in Neurofibromatosis Type 1CompletedNCT04991428Not applicable
• Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1Active, not recruitingNCT04954001Phase 1/2
• Systematically Assessing Changes in Plexiform Neurofibroma Related Disfigurement From Photographs of Subjects With Neurofibromatosis Type 1 on a Phase 2 Clinical TrialCompletedNCT04879160
• Pilot Randomized Control Trial of Telehealth Group for Improving Peer Relationships (PEERS) in NF1Status unknownNCT04860362Not applicable
• Open Trial of Telehealth Group for Improving Peer Relationships (PEERS) in NF1Status unknownNCT04856514Not applicable
• Incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) Development in Participants With Neurofibromatosis Type 1 (NF1) Receiving and Not Receiving Medical Therapies Directed at Plexiform Neurofibromas (PN)CompletedNCT04774289
• Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous NeurofibromasCompletedNCT04730583Phase 1
• Selumetinib Paediatric NF1 Japan StudyCompletedNCT04495127Phase 1
• Quality Improvement Project - "My Logbook! - I Know my Way Around!"; ("Mein Logbuch - Ich Kenne Mich Aus!")CompletedNCT04474678Not applicable
• A Long-term Study of NPC-12G Gel in Neurofibromatosis Type ITerminatedNCT04461886Phase 3
• Frameshift Peptides of Children With NF1CompletedNCT04212351
• Phase 2 Study of Tanezumab in Subjects With Moderate to Severe Pain Due to SchwannomatosisActive, not recruitingNCT04163419Phase 2
• Comparison of Gastrointestinal Motility in Healthy Children and Children With ConstipationStatus unknownNCT03981510Not applicable
• Whole-body Vibration in Children With Neurofibromatosis Type 1CompletedNCT03888248Not applicable
• Resiliency Training in Adolescents With NF1 and NF2CompletedNCT03873610Not applicable
• From Molecules to Cognition: Inhibitory Mechanisms in ASD and NF1CompletedNCT03826940Not applicable
• Whole Body MRI to Identify Atypical Neurofibromas in Patients With NF1Active, not recruitingNCT03820778Not applicable
• Prevalence of Constitutional Mismatch-repair Deficiency Among Suspected Neurofibromatosis Type 1/Legius Syndrome Children Without a Malignancy and Without a NF1 or SPRED1 MutationStatus unknownNCT03757247

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