Motor Neuron Disease: all 203 studies

Page 1 of 3. Open to participants first (61), then studies with results posted, then the rest; newest registration first within each.

• A Study of Single Ascending Doses of NI112 in Adults With Amyotrophic Lateral Sclerosis (ALS)Not yet recruitingNCT07906665Phase 1
• Register for Medical Data, Functional Scales, and Care Outcomes in ALS, SMA, and Other Motor System DisordersRecruitingNCT07900672
• Developing New Ways to Detect Respiratory Impairment Early in ALSRecruitingNCT07844590
• Rare Disease Registry Database for Movement Disorders in Southern Anhui ProvinceRecruitingNCT07838883
• Biofluid Research on Age-Related or Inherited NeurodegenerationRecruitingNCT07798700
• Digital Patient Engagement in Technology-Supported NeurorehabilitationNot yet recruitingNCT07794072
• Developing a Comprehensive Biomarker Panel for Monitoring Progression and Early Detection in ALS PatientsNot yet recruitingNCT07737977
• Serum Neurofilaments in the Diagnosis of Amyotrophic Lateral SclerosisNot yet recruitingNCT07706270
• Dorsal Root Ganglion Stimulation After Lower Motor Neuron DamageNot yet recruitingNCT07619300Not applicable
• Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealthRecruitingNCT07491484
• Safety and Tolerability Study of CTx1000 In Participants With Amyotrophic Lateral SclerosisRecruitingNCT07401121Phase 1
• Kamlanoflast In Amyotrophic Lateral SclerosisNot yet recruitingNCT07396818Phase 1/2
• Impact of Robotic Glove Use on Quality of Life, Grip Strength and Fine Motor Control in ALSEnrolling by invitationNCT07298486Not applicable
• Tracking Self-Reported Functional Needs and Quality of LifeEnrolling by invitationNCT07284810Not applicable
• Translating Single-cell Vulnerability Into Novel ALS Biomarkers and Therapeutic Targets: Towards a Liquid Nerve BiopsyRecruitingNCT07268833
• Healing ALS Registry Observational Study (HAROS)RecruitingNCT07233148
• Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)RecruitingNCT07204977Phase 1
• Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.RecruitingNCT07187388Not applicable
• GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External DevicesRecruitingNCT07127172Not applicable
• Safety of Intrathecal Riluzole in Patients With Amyotrophic Lateral SclerosisNot yet recruitingNCT07093268Phase 1
• UAE-PRIME: A Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External DevicesRecruitingNCT06992596Not applicable
• ALS Research CollaborativeRecruitingNCT06885918
• The Study Evaluating the Improvement of Nutritional Status and Frailty With Silkworm Pupa Powder Among Patients With Motor Neuron DiseaseRecruitingNCT06765499Not applicable
• AMX0114 in Adult Participants With Amyotrophic Lateral SclerosisRecruitingNCT06665165Phase 1
• An IIT Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of a Single Intrathecal Injection of SNUG01 in Patients with Amyotrophic Lateral SclerosisNot yet recruitingNCT06645197Early Phase 1
• Technical and Clinical Validation of the WPM-SEMG PrototypeRecruitingNCT06584084Not applicable
• Emotion Processing Among Patients With ALSRecruitingNCT06566651
• Spastic Paraplegia - Centers of Excellence Research NetworkRecruitingNCT06553976
• Gait Patterns in Dual-task Conditions in Patients With Amyotrophic Lateral SclerosisNot yet recruitingNCT06541873
• A Study of Ranolazine in ALSRecruitingNCT06527222Phase 2
• Digital App for Speech & Health MonitoringRecruitingNCT06450418
• Genetic Diagnosis in Inborn Errors of MetabolismEnrolling by invitationNCT06376279
• Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone DiseaseRecruitingNCT06320444
• Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral SclerosisRecruitingNCT06318598
• Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron DiseasesRecruitingNCT06318585
• MRG-001 in Patients With Amyotrophic Lateral SclerosisNot yet recruitingNCT06315608Phase 2
• Neurofilament Light Chain in Amyotrophic Lateral SclerosisRecruitingNCT06201650
• Technical Evaluation of Earswitch Phase BNot yet recruitingNCT06090448Not applicable
• Quantitative and Repetitive TMS in ALS - Recruiting for Stage 2RecruitingNCT05983211Not applicable
• Technical Evaluation of Earswitch Phase ANot yet recruitingNCT05784727Not applicable
• Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their FamiliesRecruitingNCT05744310Not applicable
• Rehabilitation and Exercise in SOD1-ALS TOfersen REcipients (RESTORE)Enrolling by invitationNCT05725759
• Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)RecruitingNCT05354622
• Volume Mode Non-invasive Ventilation in Amyotrophic Lateral SclerosisRecruitingNCT05328492Not applicable
• Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALSRecruitingNCT05204017
• Non-invasive BCI-controlled Assistive DevicesRecruitingNCT05183152Not applicable
• Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home MeasuresRecruitingNCT05137665
• Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in ChinaEnrolling by invitationNCT04961450
• Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)RecruitingNCT04944940
• Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative DiseasesRecruitingNCT04706234
• UK SMA Patient RegistryRecruitingNCT04292574
• Awareness Detection and Communication in Disorders of ConsciousnessRecruitingNCT03827187Not applicable
• Clinical Procedures to Support Research in ALSRecruitingNCT03489278
• Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal DementiaRecruitingNCT03225144
• Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS PatientsRecruitingNCT03127267Phase 3
• Amyotrophic Lateral Sclerosis and the Innate Immune SystemRecruitingNCT02869048
• Imaging Biomarkers in ALSRecruitingNCT02567136
• Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy VolunteersRecruitingNCT01900132Not applicable
• The National Amyotrophic Lateral Sclerosis RegistryRecruitingNCT01772602
• Wisconsin Brain Donor ProgramEnrolling by invitationNCT00585572
• Study of Inherited Neurological DisordersRecruitingNCT00004568
• Transcutaneous Electrical Stimulation for Spasticity in Patients With Primary Lateral SclerosisCompletedNCT06012110Not applicableResults posted
• Treatment Combining Riluzole and IFB-088 in Bulbar Amyotrophic Lateral Sclerosis (TRIALS Protocol)CompletedNCT05508074Phase 2Results posted
• MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)TerminatedNCT04579666Phase 2Results posted
• Multiple Doses of AT-1501-A201 in Adults With ALSCompletedNCT04322149Phase 2Results posted
• An Efficacy and Safety Study of Ravulizumab in ALS ParticipantsTerminatedNCT04248465Phase 3Results posted
• MN4000 for Treatment of CF and MND Patients in the Home SettingCompletedNCT03797677Not applicableResults posted
• A Safety and Tolerability Study of ILB® in Patients With Amyotrophic Lateral Sclerosis (ALS)TerminatedNCT03705390Phase 2Results posted
• Rehabilitative Trial With tDCS in Amyotrophic Lateral SclerosisCompletedNCT03293394Not applicableResults posted
• AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS)CompletedNCT03127514Phase 2Results posted
• A Trial of Tocilizumab in ALS SubjectsCompletedNCT02469896Phase 2Results posted
• Mexiletine for the Treatment of Muscle Cramps in ALSCompletedNCT01811355Phase 4Results posted
• Phase 3 Extension Study of Dexpramipexole in ALSTerminatedNCT01622088Phase 3Results posted
• Safety and Efficacy Study of Autologous Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral SclerosisCompletedNCT01363401Phase 1/2Results posted
• Phase 3 Study of Dexpramipexole in ALSCompletedNCT01281189Phase 3Results posted
• High Fat/High Calorie Trial in Amyotrophic Lateral SclerosisCompletedNCT00983983Phase 2Results posted
• Open-Label, Safety and Tolerability Extension Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) (CL211)CompletedNCT00931944Phase 2Results posted
• Safety and Tolerability Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS)CompletedNCT00647296Phase 2Results posted
• Electrical Impedance Myography as an Outcome Measure in Amyotrophic Lateral Sclerosis Clinical TrialsCompletedNCT00620698Results posted
• Effect of Noninvasive Ventilation on Lung Function in Amyotrophic Lateral SclerosisTerminatedNCT00537446Not applicableResults posted
• Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or IIITerminatedNCT00439569Phase 1/2Results posted
• Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Type ITerminatedNCT00439218Phase 1/2Results posted
• Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung FunctionCompletedNCT00076687Phase 2Results posted
• INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility StudyActive, not recruitingNCT07543367Not applicable
• Functional Outcomes and Control Using Synchron BCI - AustraliaActive, not recruitingNCT07533903Not applicable
• Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular DiseaseActive, not recruitingNCT07478172Not applicable
• Functional Outcomes and Control Using Synchron BCI - CanadaTerminatedNCT07446114Not applicable
• Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS)Active, not recruitingNCT07193953Phase 1
• Validation of the French Version of the Primary Lateral Sclerosis Functioning Rating Scale (PLSFRS)Active, not recruitingNCT06878235
• Effects of Virtual Reality-Based Balance Training Compared to Conventional Balance Training to Reduce Risk of Fall in Patients With Diabetic Peripheral Neuropathy: A Randomized Control TrialCompletedNCT06740227Not applicable
• A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)Active, not recruitingNCT06643481Phase 2
• Efficiency of Spatially Distributed Sequential Stimulation (Sdss) for Functional Electrical Stimulation (FES) of Upper Motor Neuron Syndrome (UMR) PatientsCompletedNCT06421753Not applicable
• Digital Assessment of Speech and Fine Motor Control in ALSCompletedNCT06315673
• Virtual Reality in Motor Neurone DiseaseCompletedNCT06256107Not applicable
• Implementing Spiritual Care in Inpatient Palliative CareCompletedNCT06206551
• An Open Label Extension Study of Monepantel in Individuals With Motor Neurone DiseaseCompletedNCT06177431Phase 1
• Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALSWithdrawnNCT05830214
• Left Main Intervention in Myocardial Infarction and Acute Coronary SyndromesStatus unknownNCT05701319
• Surface EMG and Ultrasound in MNDCompletedNCT05314348Not applicable
• EMERALD TRIAL Open Label Extension StudyStatus unknownNCT04997954Phase 4

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