Motor Neuron Disease: all 203 studies

Page 2 of 3. Open to participants first (61), then studies with results posted, then the rest; newest registration first within each.

• Pharmacokinetic and Pharmacodynamic Study of AMX0035 in Patients With ALSActive, not recruitingNCT04987671Phase 1/2
• Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric DisordersCompletedNCT04939818
• A Study of Monepantel in Individuals With Motor Neurone DiseaseCompletedNCT04894240Phase 1
• Holter of Movement in Patients with SMA Undergoing Treatment.Active, not recruitingNCT04888702Not applicable
• Phenotype, Genotype and Biomarkers 2Active, not recruitingNCT04875416
• "Individual Patient Expanded Access IND to Treat Primary Lateral Sclerosis"No longer availableNCT04825613
• Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS)CompletedNCT04788745Phase 2
• Virtual Peer-to-peer Support Programme for Carers of MNDCompletedNCT04695210Not applicable
• Respiratory Complications in ALSCompletedNCT04430686
• Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used in Daily Practice by ALS PeopleActive, not recruitingNCT04380649Not applicable
• Cortico-Spinal tDCS as Rehabilitative Intervention in Amyotrophic Lateral SclerosisCompletedNCT04293484Not applicable
• Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS)CompletedNCT04259255
• Tolerability, Safety and Efficacy of Sigh Breaths During NIMV in Motor Neuron DiseaseStatus unknownNCT04240925Not applicable
• A Study to Explore the Role of Gut Flora in ALSWithdrawnNCT04150809
• Biomarkers in Neurodegenerative DiseasesWithdrawnNCT04055532
• Sinemet for Spasticity and Function in Amyotrophic Lateral Sclerosis and Primary Lateral SclerosisCompletedNCT03929068Phase 1
• TRIAL READY (Clinical Trial Readiness)Active, not recruitingNCT03912987
• [BrainConnexion] - Neurodevice Phase I TrialStatus unknownNCT03811301Not applicable
• Serial Fasciculation Measurements in Motor Neurone DiseaseCompletedNCT03809845Not applicable
• Inhibition of Rho Kinase (ROCK) With Fasudil as Disease-modifying Treatment for ALSCompletedNCT03792490Phase 2
• Validation Of Tidal/End -Tidal CO2 in ALSStatus unknownNCT03764384
• Study of ALS Reversals 4: LifeTime ExposuresCompletedNCT03706391
• Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone DiseaseStatus unknownNCT03690791Phase 3
• Assessing Motor Neuron Disease Mechanisms by Threshold Tracking Transcranial Magnetic Stimulation and Magnetic Resonance SpectroscopyWithdrawnNCT03664206
• Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS)CompletedNCT03560661
• Clinical Trial of Ultra-high Dose Methylcobalamin for ALSCompletedNCT03548311Phase 3
• IC14 for Treatment of Amyotrophic Lateral SclerosisWithdrawnNCT03508453Phase 2
• Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone DiseaseCompletedNCT03487263Phase 1
• Study of ALS Reversals 2: Genetic AnalysesCompletedNCT03464903
• Novel MRI Biomarkers for Monitoring Disease Progression in ALSActive, not recruitingNCT03362658
• Rapamycin Treatment for ALSCompletedNCT03359538Phase 2
• The General Breathing Record StudyCompletedNCT03356288
• Safety/Efficacy Study of 2nd Cycle Treatment After 6 Months of 1st Cycle HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in ALSStatus unknownNCT03214146Phase 1
• A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps.TerminatedNCT03196375Phase 2
• EncoreAnywhere Use in Motor Neurone DiseaseCompletedNCT03154450Not applicable
• Effect of MD1003 in Amyotrophic Lateral SclerosisCompletedNCT03114215Phase 2
• Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron DiseaseStatus unknownNCT03067857Phase 1/2
• Escalated Application of Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis PatientsCompletedNCT02987413Phase 1
• Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MNDCompletedNCT02870634Phase 1
• Use of Dalfampridine in Primary Lateral SclerosisCompletedNCT02868567Phase 1
• A Patient Centric Motor Neuron Disease Activities of Daily Living ScaleCompletedNCT02852278
• Deep Phenotyping in Patients With ALSCompletedNCT02819765
• Genomic Translation for Amyotrophic Lateral Sclerosis CareCompletedNCT02795897
• Safety and Efficacy Study of NP001 in Patients With Amyotrophic Lateral Sclerosis (ALS) and Systemic InflammationCompletedNCT02794857Phase 2
• Evaluation of Usability and Human Factors in the Novus SystemStatus unknownNCT02738242Not applicable
• Answer ALS: Individualized Initiative for ALS DiscoveryCompletedNCT02574390
• Genetics of Pediatric-Onset Motor Neuron and Neuromuscular DiseasesCompletedNCT02532244
• Telehealth in Motor Neurone DiseaseCompletedNCT02464748Not applicable
• Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron FunctionCompletedNCT02408900
• MRI Biomarkers in ALSCompletedNCT02405182
• Study of Predictive Factors of Progression of Motor Neurone DiseaseCompletedNCT02360891
• Phenotype, Genotype & Biomarkers in ALS and Related DisordersActive, not recruitingNCT02327845
• Cell Therapy for Motor Neuron Disease/Amyotrophic Lateral SclerosisWithdrawnNCT02242071Phase 1
• Study of Hepatic Function in Patients With Spinal and Bulbar Muscular AtrophyCompletedNCT02124057
• Study of Electrical Impedance Myography (EIM) in ALSCompletedNCT02011204
• Differential Study of Muscle TranscriptomeCompletedNCT01984957Not applicable
• LIME Study (LFB IVIg MMN Efficacy Study)CompletedNCT01951924Phase 3
• Establishment of a Tissue Bank (Blood, CSF) for the Understanding of Motor Neuron Disease (MND)TerminatedNCT01950910
• Identification of Diagnostic And Prognostic Biomarkers From Amyotrophic Lateral Sclerosis (ALS) Skin and Adipose SamplesCompletedNCT01948102
• Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene MutationCompletedNCT01925196
• Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron DiseaseCompletedNCT01776970Phase 2/3
• Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral SclerosisCompletedNCT01758510Phase 1
• Long-term Surveillance of the MedStream Programmable Infusion SystemTerminatedNCT01712087
• Human Neural Stem Cell Transplantation in Amyotrophic Lateral Sclerosis (ALS)CompletedNCT01640067Phase 1
• Humanitarian Device Exemption Post-Approval Study of NeuRx Diaphragm Pacing System for Amyotrophic Lateral SclerosisCompletedNCT01605006Not applicable
• Muscle Training of Patients With Amyotrophic Lateral Sclerosis (ALS)CompletedNCT01504009Not applicable
• A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) BiomarkersCompletedNCT01495390
• Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular DisordersWithdrawnNCT01459302
• Effect of Functional Exercise in Patients With Spinal Bulbar Muscular AtrophyCompletedNCT01369901Phase 1/2
• Oxidative Stress in Motor Neuron Disease: COSMOS Add-On StudyCompletedNCT01143428
• Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral AclerosisCompletedNCT00956488Phase 1/2
• Genetics of Familial and Sporadic ALSCompletedNCT00821132
• Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patient PopulationCompletedNCT00718497
• EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS)CompletedNCT00718458
• Pennsylvania Consortium: Clinical DatabaseTerminatedNCT00718445
• Compassionate Use of Ceftriaxone in Patients With Amyotrophic Lateral Sclerosis (ALS)CompletedNCT00718393
• Satisfaction Survey for Amyotrophic Lateral Sclerosis (ALS) Patients Comparing Rooms With and Without Assistive TechnologyTerminatedNCT00718107
• Assessment of the Cyberlink Control System for Use by the Amyotrophic Lateral Sclerosis (ALS) PatientTerminatedNCT00718016
• Noninvasive Examination of the Work of Breathing in Patients With Amyotrophic Lateral Sclerosis (ALS).TerminatedNCT00718003
• Amyotrophic Lateral Sclerosis (ALS) Tissue Donation ProgramCompletedNCT00716131
• Cerebrospinal Fluid RepositoryCompletedNCT00714636
• Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral SclerosisCompletedNCT00706147Phase 2/3
• Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)CompletedNCT00677768
• Efficacy of Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)CompletedNCT00537641
• The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS)CompletedNCT00409721Phase 2
• Noninvasive Ventilation in ALS Patients With Mild Respiratory InvolvementCompletedNCT00386464Phase 2/3
• Collection of Blood Samples for DNA in Motor Neuron DiseaseCompletedNCT00362362
• Combination Therapy Selection Trial in Amyotrophic Lateral SclerosisCompletedNCT00355576Phase 2
• Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS)CompletedNCT00353665Phase 2/3
• Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral SclerosisCompletedNCT00334516
• Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron DiseaseCompletedNCT00324454Phase 2
• Pilot-Study of Thalidomide in Amyotrophic Lateral Sclerosis (ALS)TerminatedNCT00231140Phase 2
• Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS)CompletedNCT00125203Phase 2/3
• Brain Physiology in Polio SurvivorsCompletedNCT00080600
• Brain Function in Primary Lateral SclerosisCompletedNCT00071435
• Measuring Levels of SMN in Blood Samples of SMA PatientsCompletedNCT00061607
• Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral SclerosisCompletedNCT00023075
• Screening and Natural History: Primary Lateral Sclerosis and Related DisordersCompletedNCT00015444
• Physiologic Studies of SpasticityCompletedNCT00014976
• Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron DiseaseCompletedNCT00004771Phase 2

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