Molar Hypomineralization clinical trials
The registry lists 133 studies for Molar Hypomineralization across more than 10 countries. 46 are recruiting or about to start. 121 of them are mainly about Molar Hypomineralization (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Status
Who runs them
Cairo University (22) · Marmara University (9) · University of Nove de Julho (7) · Alexandria University (6) · Hacettepe University (5) · King Abdullah University Hospital (4) · Ain Shams University (4) · University of Sao Paulo (3)
What is being tested here
Drugs under test in Molar Hypomineralization studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Potassium nitrate | 1 | 0 | 1 |
| Sodium Fluoride | 1 | 1 | 1 |
| Ibuprofen | 1 | 0 | 1 |
| Carticaine | 0 | 0 | 2 |
| Cholecalciferol | 0 | 0 | 1 |
| Fluorides, Topical | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Hydroxyapatite vs Fluoride Toothpaste for MIH Remineralization · Dubai Health
- Nov 2026Nanohydroxyapatite Versus Sodium Fluoride Varnish in Remineralizing MIH Anterior Teeth · Tanta University
- Nov 2026Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) Children · Ankara Yildirim Beyazıt University
- Dec 2026The Effect of Salvadora Persica (Miswak) Compared to Fluoridated Toothpaste on Children's Teeth Diagnosed With Molar-Incisor Hypomineralization (MIH): A Randomized Clinical Trial · King Abdulaziz University
- Dec 2026Correlation Between Colour of Defect and Enamel Breakdown in First Permanent Molars With Molar Incisor Hypomineralisation (MIH) · University of Basel
- Jan 2027Clinical Efficacy of Calcium and Sodium Phosphosilicate (Novamin) in the Treatment of MIH (Molar Incisor Hypolimineralization) in Pediatric Patients · University of Pavia
- Jan 2027Clinical Evaluation of Resin Infiltration Treatment of MIH-affected Teeth in Pediatric Patients · Inonu University
- Mar 2027Computer-aided Design/Computer-aided Manufacturing for Mild to Moderate Molar Incisor Hypomineralization Treatment · University Hospital, Toulouse
- Mar 2027Aesthetic Masking and Resin Infiltration Time in MIH-affected Incisors · Alexandria University
- Jun 2027Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste · King Abdulaziz University
Who these studies take
Of the 15 Molar Hypomineralization studies recruiting now, 0 (0%) set no upper age limit and 15 (100%) stop at 75 or younger. 15 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 10 (67%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 13 (87%) | 13 (87%) |
| 18 | 1 (7%) | 1 (7%) |
| 30 | 1 (7%) | 1 (7%) |
| 40 | 1 (7%) | 1 (7%) |
| 50 | 1 (7%) | 1 (7%) |
| 65 | 0 (0%) | 0 (0%) |
| 75 | 0 (0%) | 0 (0%) |
| 85 | 0 (0%) | 0 (0%) |
Across all 133 studies, recruiting or not: 98% stop at 75 or younger and 98% at 65; 96% take children; 0% are for women only and 0% for men only; 61% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Molar Hypomineralization studies take
Of 62 interventional studies with no phase under Molar Hypomineralization, half reached primary completion within 14 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 14 mo8–25 · 62 studies | — | 14 mo8–25 · 62 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered4
- Risk of Caries and Enamel Abnormalities in Patients With Cleft PalateNov 9, 2026NCT07926646
- Clinical Performance of Glass Hybrid and Alkasite Restorative Systems in MIH-Affected Permanent First MolarsOct 30, 2026NCT07906548
- Nanohydroxyapatite Versus Sodium Fluoride Varnish in Remineralizing MIH Anterior TeethOct 26, 2026NCT07894510
- Molar-Incisor Hypomineralization and Resin InfiltrationOct 14, 2026NCT07873268
Studies
Recruiting first, then most recently updated. Showing 50 of 133. Browse all 133 → or search them.
- Risk of Caries and Enamel Abnormalities in Patients With Cleft PalateNot yet recruitingNCT07926646Not applicable1 country
- Clinical Performance of Glass Hybrid and Alkasite Restorative Systems in MIH-Affected Permanent First MolarsNot yet recruitingNCT07906548Not applicable1 country
- Nanohydroxyapatite Versus Sodium Fluoride Varnish in Remineralizing MIH Anterior TeethRecruitingNCT07894510Not applicable1 country
- Molar-Incisor Hypomineralization and Resin InfiltrationRecruitingNCT07873268Not applicable1 country
- Nano Silver Fluoride and Photobiomodulation Therapy for Hypersensitivity and Pain in MIH-Affected MolarsNot yet recruitingNCT07826130Not applicable
- Pre-etched Bioactive Versus Resin- Based Fissure Sealant for Permanent Molars Affected With Molar Incisor Hypomineralization (MIH).Enrolling by invitationNCT07504614Not applicable1 country
- Aesthetic Masking and Resin Infiltration Time in MIH-affected IncisorsNot yet recruitingNCT07753070Not applicable1 country
- Comparison of Computer-Assisted and Conventional Local Anesthesia in Children With Molar-Incisor HypomineralizationNot yet recruitingNCT07733011Not applicable1 country
- Correlation Between Colour of Defect and Enamel Breakdown in First Permanent Molars With Molar Incisor Hypomineralisation (MIH)RecruitingNCT077272001 country
- Correlation Between Colour and Hypersensitivity of First Permanent Molars With Molar Incisor Hypomineralisation (MIH)RecruitingNCT077270441 country
- Direct Composite Versus Indirect Hybrid Resin Restorations in Hypomineralized First Permanent MolarsNot yet recruitingNCT07718191Not applicable
- Assessment of Peridontal Inflamatuar Markers in MIHNot yet recruitingNCT077016421 country
- Effect of Enamel Cleaning on a Remineralizing Paste for Hypomineralizated LesionsNot yet recruitingNCT07653373Not applicable1 country
- Evaluation of Occlusal Force and Masticatory Function in Children With Molar-Incisor HypomineralizationNot yet recruitingNCT07589179Not applicable
- Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite ToothpasteRecruitingNCT07436039Not applicable1 country
- Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized MolarsRecruitingNCT05964387Not applicable1 country
- Preemptive Analgesia for Pain and Anxiety Control in Children With MIHRecruitingNCT07374354Not applicable1 country
- The Effect of Salvadora Persica (Miswak) Compared to Fluoridated Toothpaste on Children's Teeth Diagnosed With Molar-Incisor Hypomineralization (MIH): A Randomized Clinical TrialNot yet recruitingNCT07355465Not applicable
- Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) ChildrenRecruitingNCT07352813Not applicable1 country
- Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical StudyNot yet recruitingNCT07329244Not applicable1 country
- Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected MolarsNot yet recruitingNCT07326241Not applicable1 country
- Hydroxyapatite vs Fluoride Toothpaste for MIH RemineralizationNot yet recruitingNCT07177053Phase 2
- Selective Versus Non-selective Caries Excavation in MIH Affected Teeth.Enrolling by invitationNCT07142629Not applicable1 country
- BIOSILITACE AS A DESENSITIZING AGENTIN HMINot yet recruitingNCT07080645Not applicable1 country
- Pain Perception and Anxiety With Virtual Reality vs Tell-Show-Do in Children With MIHNot yet recruitingNCT07052019Not applicable1 country
- Colorimetric, Ultra-structural and Elemental Comparison of Dental Enamel DefectsRecruitingNCT047040891 country
- Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent TeethNot yet recruitingNCT06896565Not applicable
- Clinical Performance of Giomer Preceded by Etching Versus Resin-Based Sealants Applied on Permanent Molars Affected by Molar-Incisor Hypo-mineralizationNot yet recruitingNCT06922552Not applicable1 country
- Photobiomodulation and New Restorative Material for Teeth With MIH on Control of Hypersensitivity and LongevityNot yet recruitingNCT06538142Not applicable
- Clinical Evaluation of Two Different Pit and Fissure SealantsRecruitingNCT06776471Not applicable1 country
- Prevalence of Hypomineralized Second Primary Molars and Its Association with Molar-Incisor Hypomineralization.Not yet recruitingNCT06727539
- Prevalence of MIH in Young Adults At Cairo University Dental Hospital and Its Link to Dental Cavities: a Cross-Sectional StudyNot yet recruitingNCT067015521 country
- This Study Aims to Evaluate the Effect of Rinsing Off or Blot-drying Silver Fluoride on the Retention of Subsequently-applied Resin- and Glass Ionomer-based Fissure Sealants in Permanent Molars Affected by Molar-Incisor Hypomineralization.RecruitingNCT06641011Not applicable1 country
- Prevalence And Severity Of Molar Incisor Hypomineralization Among A Group Of Children With Type I Diabetes Milletus.Not yet recruitingNCT06342089
- Clinical Efficacy of Calcium and Sodium Phosphosilicate (Novamin) in the Treatment of MIH (Molar Incisor Hypolimineralization) in Pediatric PatientsEnrolling by invitationNCT06396988Not applicable1 country
- Use of a Glass Ionomer Sealant in Molar Incisor HypomineralizationRecruitingNCT058063981 country
- Effects of Different Remineralization Agents on Molar Incisor Hypomineralization Defects: a Randomized Clinical StudyRecruitingNCT06362681Not applicable1 country
- Association Between Molar-Incisor Hypomineralization, Maternal Stress and Anxiety: A Cross-Sectional Study.Not yet recruitingNCT06081491
- Clinical Efficacies of Different Agents in Molar-Incisor HypomineralizationNot yet recruitingNCT06180369Not applicable
- Single Gene Polymorphisms Associated With Molar-Incisor HypomineralizationNot yet recruitingNCT06165055
- HYPERSENSITIVITY IN MOLAR INCISOR HYPOMINERALISATION USING LOW LEVEL LASER IN CHILDRENNot yet recruitingNCT06154733Not applicable
- Effectiveness of Pulpotomy in Carious First Permanent MolarNot yet recruitingNCT06137391Not applicable
- Evaluation of Antimicrobial Photodynamic Therapy and Minimal Intervention Associated With Deproteinization in Permanent Teeth With Molar Incisor HypomineralizationRecruitingNCT05443035Phase 1/21 country
- Evaluation of Three Different Minimally Invasive Techniques for Management of Enamel Opacities in Patients With Molar Incisor Hypomineralization "Randomized Controlled Clinical Trial"Not yet recruitingNCT06135272Phase 41 country
- Comparative Evaluation of Giomer Varnish vs Fluoride Varnish as Desensitizing Agents in Teeth With MIHNot yet recruitingNCT05542667Phase 3
- Effect of Glass-Ionomer Sealing Technique on Hypersensitive Teeth With Molar Incisor HypomineralisationRecruitingNCT05945381Not applicable1 country
- Computer-aided Design/Computer-aided Manufacturing for Mild to Moderate Molar Incisor Hypomineralization TreatmentActive, not recruitingNCT04922177Not applicable1 country
- Intraosseus Injection Using Extra-short Needle Combined With Infiltration in Pediatric Patients With Molar Incisor HypomineralizationCompletedNCT07239050Not applicable1 country
- Hypersensitivity After Composite Restoration Versus Preformed Metal Crowns in MIH MolarsCompletedNCT04654858Not applicable1 country
- Clinical Comparison of CAD/CAM Nanohybrid Composite and Hybrid Ceramic Overlays in Children With Molar-Incisor HypomineralisationCompletedNCT06987448Not applicable1 country